Asymmetric construction of quaternary α-nitro amides by palladium-catalyzed C(sp)-H arylation.

Pd-Catalyzed enantioselective C(sp3)-H arylation of N-(o-Br-aryl) anilides has been disclosed, and quaternary α-nitro amides were constructed with up to 98% ee. The presence of the nitro group on the substrate enables the progress of the reaction and the ready transformation of the product to optically active quaternary amino acid derivatives.

[Renal protective effects of specific cyclooxygenase-2 inhibitor in rats with subtotal renal ablation].

Objective: To investigate the renoprotective effect of specific cyclooxygenase-2 (COX-2) inhibitor rofecoxib and its possible mechanism of retarding progressive renal injury in rats with subtotal renal ablation.

Methods: Rats were randomly divided into six groups: sham, subtotal renal ablation (SNX). SNX treated with rofecoxib (10 mg.