Publications by authors named "Wei-Xiang Lin"
Four new (penigrisacids A-D, -) and one known () carotane sesquiterpenoids were isolated from the deep-sea-derived fungus , along with four known compounds (-). The planar structures and relative configurations of the new compounds were determined by extensive analysis of the NMR and HRESIMS data. The absolute configurations were established by comparison of the experimental and calculated ECD (electronic circular dichroism) spectra or OR (optical rotation) value.
View Article and Find Full Text PDFFrom the deep sea-derived MCCC 1A01570, eight cyclic dipeptides (1-8) and five phenolics (9-13) were obtained. Cyclo-(I-Pro-D-Leu) (4) could moderately promote the gene transcriptional function of nuclear receptor RXRα, while , , and showed weak reduction in RXRα gene transcriptional activities induced by 9--retinoid acid (RA). These compounds might have beneficial effects against intractable diseases with relation to RXRα, such as cancer and metabolic diseases, due to their potential activities on regulating the transcriptional activation function of RXRα.
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- Researchers isolated butyrolactone I (BTL-I) from deep-sea Aspergillus sp. and tested it on mice to see if it could reduce food allergies caused by ovalbumin (OVA).
- BTL-I successfully lessened allergy symptoms by lowering histamine levels, inhibiting specific IgE, and reducing mast cell populations in the spleen and lymph nodes, while also affecting mast cell activation.
- Additionally, BTL-I was found to interact with the inhibitory receptor FcγRIIB, suggesting that its protective effects against food anaphylaxis may be linked to diminished mast cell function.
Article Synopsis
- The research on the left ventricular assist device (LVAD) in Beijing involved preliminary studies with sheep and goats over three years.
- Seven animals have been implanted with the LVAD, showing promising initial results.
- The latest test subject, a goat, survived just under 12 days before dying from a renal embolism, paving the way for future artificial heart studies.