Synthetic studies towards anti-SARS agents: application of an indium-mediated allylation of α-aminoaldehydes as the key step towards an intermediate.

was identified as a good starting point for modification, leading to an efficient and bio-available inhibitor for the SARS coronavirus main proteinase (SARS-CoV M). Synthesis of intermediate and analogues proceeded via a highly diastereoselective indium-mediated allylation of α-aminoaldehydes.