[Impact of Accelerated Electrification Under the Low Carbon Path in Dongguan City on the Coordinated Emission Reduction of CO and Pollutants].

Cities are the center of energy consumption. Electrification integrates urban energy structure and achieves the efficient use of clean energy. Exploring the urban impact of accelerated electrification under the low-carbon path is crucial to reducing urban pollution and carbon.

Ketamine alleviates fear memory and spatial cognition deficits in a PTSD rat model via the BDNF signaling pathway of the hippocampus and amygdala.

Background: Post-traumatic stress disorder (PTSD) is associated with traumatic stress experiences. This condition can be accompanied by learning and cognitive deficits. Studies have demonstrated that ketamine can rapidly and significantly alleviate symptoms in patients with chronic PTSD.

(2R,6R)-hydroxynorketamine acts through GluA1-induced synaptic plasticity to alleviate PTSD-like effects in rat models.

Post-traumatic stress disorder (PTSD) is a debilitating mental disorder with high morbidity and great social and economic relevance. However, extant pharmacotherapies of PTSD require long-term use to maintain effectiveness and have enormous side effects. The glutamatergic system, especially the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR), is an important target of current research on the mechanism of PTSD.

An Efficient IAKF Approach for Indoor Positioning Drift Correction.

In this study, an indoor positioning shift correction architecture was developed with an improved adaptive Kalman filter (IAKF) algorithm for the people interference condition. Indoor positioning systems (IPSs) use ultra-wideband (UWB) communication technology. Triangulation positioning algorithms are generally employed for determining the position of a target.

[Nonlinear Response Relationship Between Ozone and Precursor Emissions in the Pearl River Delta Region Under Different Transmission Channels].

With the rapid development of urbanization, ozone (O) pollution is an ongoing occurrence in the Pearl River Delta (PRD) region in China. The effective control of O pollution is a great challenge owing to the nonlinear relationship between O and precursor emissions and the effect of meteorological conditions. Based on the regional air quality model CAMx-OSAT (ozone source apportionment technology), O formation regimes were determined, and inter-city transportation across PRD was quantified under different transmission channels.

Hydroxychloroquine Increased Anxiety-Like Behaviors and Disrupted the Expression of Some Related Genes in the Mouse Brain.

Hydroxychloroquine (HCQ), which has been proposed as a therapeutic or prophylactic drug for COVID-19, has been administered to thousands of individuals with varying efficacy; however, our understanding of its adverse effects is insufficient. It was reported that HCQ induced psychiatric symptoms in a few patients with autoimmune diseases, but it is still uncertain whether HCQ poses a risk to mental health. Therefore, in this study, we treated healthy mice with two different doses of HCQ that are comparable to clinically administered doses for 7 days.

[Characteristics and Meteorological Factors of Complex Nonattainment Pollution of Atmospheric Photochemical Oxidant (O) and PM in the Pearl River Delta Region, China].

Based on the atmospheric pollutant data from twelve monitoring sites in the Guangdong-Hong Kong-Macao Pearl River Delta Regional Air Quality Monitoring Network, the mass concentration trends of atmospheric photochemical oxidants (O, NO+O) and PM during 2013-2017 were studied. The complex nonattainment pollution of O and PM is defined as the daily average mass concentration of NO and PM and daily maximum 8 h average (O MDA8) mass concentration of O simultaneously that exceeds the Chinese grade Ⅱ national air quality standard. The characteristics and meteorological factors that influence the complex nonattainment pollution of O and PM at different types of areas were analyzed.

All-Solid-State Rechargeable Lithium Metal Battery with a Prussian Blue Cathode Prepared by a Nonvacuum Coating Technology.

A Prussian blue LiFeFe(CN) thin-film cathode is fabricated by a nonvacuum coating technology without post-annealing process. The thin film of the solid electrolyte lithium phosphorus oxynitride (LiPON) is deposited onto the cathode by using radio-frequency magnetron sputtering. Then, the lithium metal anode is deposited on the LiPON film by the thermal evaporation method to fabricate the all-solid-state LiFeFe(CN)/LiPON/Li battery with a thickness of 16 μm and a size of ∼10 cm.

Assistive Control System for Upper Limb Rehabilitation Robot.

This paper presents an assistive control system with a special kinematic structure of an upper limb rehabilitation robot embedded with force/torque sensors. A dynamic human model integrated with sensing torque is used to simulate human interaction under three rehabilitation modes: active mode, assistive mode, and passive mode. The hereby proposed rehabilitation robot, called NTUH-ARM, provides 7 degree-of- freedom (DOF) motion and runs subject to an inherent mapping between the 7 DOFs of the robot arm and the 4 DOFs of the human arm.

Sodium salicylate suppresses GABAergic inhibitory activity in neurons of rodent dorsal raphe nucleus.

Sodium salicylate (NaSal), a tinnitus inducing agent, can activate serotonergic (5-HTergic) neurons in the dorsal raphe nucleus (DRN) and can increase serotonin (5-HT) level in the inferior colliculus and the auditory cortex in rodents. To explore the underlying neural mechanisms, we first examined effects of NaSal on neuronal intrinsic properties and the inhibitory synaptic transmissions in DRN slices of rats by using whole-cell patch-clamp technique. We found that NaSal hyperpolarized the resting membrane potential, decreased the input resistance, and suppressed spontaneous and current-evoked firing in GABAergic neurons, but not in 5-HTergic neurons.

[Risk factors associated with chronic obstructive pulmonary disease: a comparison between urban and rural populations in Chengdu].

Objective: To determine risk factors associated with the prevalence of chronic obstructive pulmonary disease (COPD) in urban and rural populations in Chengdu.

Methods: A multistage random cluster sampling method was adopted to select participants from four communities in Chengdu. All residents aged 40-70 yr.

Juvenile stress affects anxiety-like behavior and limbic monoamines in adult rats.

Epidemiological evidence suggests that childhood and adolescent maltreatment is a major risk factor for mood disorders in adulthood. However, the mechanisms underlying the manifestation of mental disorders during adulthood are not well understood. Using a recently developed rat model for assessing chronic variable stress (CVS) during early adolescence (juvenility), we investigated the long-term effects of juvenile CVS on emotional and cognitive function and on monoaminergic activities in the limbic areas.

Microarray analysis of transcriptome of medulla identifies potential biomarkers for Parkinson's disease.

To complement the molecular pathways contributing to Parkinson's disease (PD) and identify potential biomarkers, gene expression profiles of two regions of the medulla were compared between PD patients and control. GSE19587 containing two groups of gene expression profiles [6 dorsal motor nucleus of the vagus (DMNV) samples from PD patients and 5 from controls, 6 inferior olivary nucleus (ION) samples from PD patients and 5 from controls] was downloaded from Gene Expression Omnibus. As a result, a total of 1569 and 1647 differentially expressed genes (DEGs) were, respectively, screened in DMNV and ION with limma package of R.

Corticotropin-releasing factor in the norepinephrine nucleus, locus coeruleus, facilitates behavioral flexibility.

Corticotropin-releasing factor (CRF), the stress-related neuropeptide, acts as a neurotransmitter in the brain norepinephrine nucleus, locus coeruleus (LC), to activate this system during stress. CRF shifts the mode of LC discharge from a phasic to a high tonic state that is thought to promote behavioral flexibility. To investigate this, the effects of CRF administered either intracerebroventricularly (30-300 ng, i.

[Effects of predator stress on the expression of cAMP responsive element binding protein in hippocampus: experiment with rats].

Objective: To explore the neurobiological basis involved in the pathogenesis of the lasting emotionality and cognitive impairment following severe psychological stress.

Methods: Ninety-six male Wistar rats were divided randomly into 2 equal groups: group of predator stress (Group PS) put into a cage in the experimental box singly to be exposed to a cat in the box but outside the cage for 23-57 min until tremor, polypnea, and nares flaring appeared for 6 min so as to establish predator stress models, and control group, put into the cage without non-injurious exposure of cat. 1, 12, and 24 hours later 8 rats from each group were killed with the hippocampus taken out.