Publications by authors named "Wei-Ting Ge"
Objective: Liver metastasis is one of the prognostic factors of colorectal cancer (CRC). The aim of this study is to identify biomarkers that facilitate easier detection of liver metastasis.
Methods: Significance Analysis of Microarrays (SAM) and Array Data Analyzer (ADA) were applied used for the analysis of differentially differently expressed mRNAs.
The dominant negative mutant Artemis enhances tumor cell radiosensitivity.
Radiother Oncol
October 2011
Background: Tumor radioresistance often leads to treatment failure during radiotherapy. New strategies like developing radiosensitizer are clinically important. Intervention with DNA double-strand break repair is an effective way to modulate tumor cell radiosensitivity.
View Article and Find Full Text PDFAim: To investigate the expression of markers that are correlated with the prognosis of colorectal cancer (CRC) patients.
Methods: One hundred and fifty-six CRC patients were followed up for more than 3 years after radical surgery. Immunohistochemical (IHC) analysis was performed to detect the expression of 14 pathway-related markers (p53, APC, p21ras, E-cadherin, endothelin-B receptor, Shp2, ADCY-2, SPARCL1, neuroligin1, hsp27, mmp-9, MAPK, MSH2 and rho) in specimens from these patients.
Objective: The purpose of this study was to determine the unique and universal features of microsatellite instability-high (MSI-H) colorectal cancer (CRC) and MSI-H gastric cancer (GC) in the Chinese population.
Methods: A new panel of mononucleotide MSI markers, BAT25, BAT26, NR21, NR24, and MONO-27, was used to define MSI status in 303 CRC and 288 GC subjects. Clinicopathological features of both types of MSI-H tumors were analyzed.
Effect of SNC19/ST14 gene overexpression on invasion of colorectal cancer cells.
World J Gastroenterol
September 2005
Aim: To study the effect of SNC19/ST14 gene overexpression on invasion in vitro of colorectal cancer cells.
Methods: The adhesion of SNC19/ST14 gene-transfected cells to ECM was measured by MTT assay. The cell movement was evaluated by wound healing assay.
Article Synopsis
- This study aimed to investigate how the SNC19/ST14 gene affects the behavior of colorectal cancer cells after being introduced into them.
- The gene was successfully inserted into RKO colorectal cancer cells using a specific vector, and various methods were employed to analyze cell characteristics such as growth, adhesion, and cytoskeletal changes.
- Results showed that while SNC19/ST14 altered the organization of F-actin and reduced cell adherence to the extracellular matrix, it did not significantly change the cell cycle, apoptosis, or overall cell proliferation, except at high expression levels.