Publications by authors named "Wei-Ran Liu"
Article Synopsis
- This study explored the role of circulating genetically abnormal cells (CACs) as a potential noninvasive biomarker for the early diagnosis of non-small cell lung cancer (NSCLC).
- A total of 339 participants, including 261 lung cancer patients and 78 healthy volunteers, were evaluated using a fluorescence technique to detect CACs in peripheral blood, revealing a higher abundance of CACs in early-stage NSCLC patients compared to healthy individuals.
- The CAC test showed good diagnostic ability with 67.2% sensitivity and 80.8% specificity, outperforming traditional serum tumor markers, particularly in detecting smaller nodules associated with NSCLC.
First-generation EGFR tyrosine kinase inhibitors (TKIs) such as erlotinib have significant activity in NSCLC patients with activating EGFR mutations. However, EGFR-TKI resistance inevitably occurs after approximately 12 months of treatment. Acquired mechanisms of resistance, other than secondary mutations in EGFR (T790 M) which account for 50-60%, are less well understood.
View Article and Find Full Text PDF[Correlation of cognitive impairment and Tau protein phosphorylation after isoflurane exposure in senile rats].
Zhonghua Yi Xue Za Zhi
August 2012
Objective: To examine whether the isoflurane-induced spatial memory changes is associated with AD pathogenesis of tau protein phosphorylation.
Methods: We exposed 18-month-old male Sprague-Dawley rats to 1.4% isoflurane for 2 hours (anesthesia group, n = 31).