Prediction of post-transplant graft survival by different definitions of early allograft dysfunction.

Background: The efficacy of early allograft dysfunction (EAD) definitions in predicting post-transplant graft survival in a Chinese population is still unclear.

Methods: A total of 607 orthotopic liver transplants (OLT) have been included in the current study. Model accuracy was evaluated using receiver operating characteristic (ROC) analysis.

MiR-486-5p negatively regulates oncogenic NEK2 in hepatocellular carcinoma.

NEK2 is a member of the NIMA-related family of serine/threonine centrosomal kinases. We analyzed the relationship between differential expression of NEK2 and hepatocellular carcinoma (HCC) patient outcomes after liver transplants. We also studied the microRNAs that affect NEK2 expression.

A simplified multivisceral transplantation procedure for patients with combined end-stage liver disease and type 2 diabetes mellitus.

In liver transplant patients with type 2 diabetes mellitus (DM), the disease worsens after transplantation because of longterm use of diabetogenic immunosuppressive drugs, making management of those patients a great challenge. The objective of our study was to evaluate the safety and efficacy of a simplified multivisceral transplantation (SMT) procedure for the treatment of patients with end-stage liver disease and concurrent type 2 DM. Forty-four patients who had pretransplant type 2 DM were included.

Prognostic value of combined preoperative fibrinogen and neutrophil-lymphocyte ratio in patients with hepatocellular carcinoma after liver transplantation.

Objectives: Elevated plasma fibrinogen (Fib) correlated with patient's prognosis in several solid tumors. However, few studies have illuminated the relationship between preoperative Fib and prognosis of HCC after liver transplantation. We aimed to clarify the prognostic value of Fib and whether the prognostic accuracy can be enhanced by the combination of Fib and neutrophil-lymphocyte ratio (NLR).

Prognostic value of combined preoperative lactate dehydrogenase and alkaline phosphatase levels in patients with resectable pancreatic ductal adenocarcinoma.

Serum enzymes, including lactate dehydrogenase (LDH) and alkaline phosphatase (ALP), have recently been reported to play important roles in tumor growth. Increases in LDH and ALP have been confirmed to predict poor prognosis in patients with various cancers. However, their prognostic value in pancreatic cancer has not been well studied.

miR-26a regulates mouse hepatocyte proliferation via directly targeting the 3' untranslated region of CCND2 and CCNE2.

Background: The deficiency of liver regeneration needs to be addressed in the fields of liver surgery, split liver transplantation and living donor liver transplantation. Researches of microRNAs would broaden our understandings on the mechanisms of various diseases. Our previous research confirmed that miR-26a regulated liver regeneration in mice; however, the relationship between miR-26a and its target, directly or indirectly, remains unclear.

Pathological characteristics of liver allografts from donation after brain death followed by cardiac death in pigs.

Donation after brain death followed by circulatory death (DBCD) is a unique practice in China. The aim of this study was to define the pathologic characteristics of DBCD liver allografts in a porcine model. Fifteen male pigs (25-30 kg) were allocated randomly into donation after brain death (DBD), donation after circulatory death (DCD) and DBCD groups.

Liver transplantation using organs from deceased organ donors: a single organ transplant center experience.

Background: In 2011, a pilot program for deceased organ donation was initiated in China. We describe the first successful series of liver transplants in the pilot program.

Methods: From July 2011 to August 2012, our center performed 26 liver transplants from a pool of 29 deceased donors.

[Efficacy and safety of sorafenib in the prevention and treatment of hepatocellular carcinoma recurrences after liver transplantation].

Objective: To evaluate the efficacy and safety of sorafenib in the prevention and treatment of hepatocellular carcinoma (HCC) relapse after liver transplantation.

Methods: A retrospective cohort study was performed to assess the efficacy and safety of sorafenib for HCC. Forty-four patients who underwent liver transplant for HCC beyond Milan criteria form July 2007 to May 2010 were included study group (sorafenib, n = 22) and control group (without sorafenib, n = 22).

[Clinical characteristics, diagnosis and treatment of digestive tract leakage after orthotopic liver transplantation].

Objective: To investigate the clinical characteristics, diagnosis and treatment of digestive tract leakage after orthotopic liver transplantation (OLT).

Methods: Sixty-one recipients had digestive tract leakage in early stage after OLT among 1173 cases from January 2000 to December 2010. There were 55 male and 6 female patients, aging from 36 to 61 years, with a median of 45 years.

Twenty-four hour steroid avoidance immunosuppressive regimen in liver transplant recipients.

Objectives: To investigate the efficacy and safety of an immunosuppressive regimen of steroid avoidance in combination with induction therapy and tacrolimus in liver transplant recipients.

Materials And Methods: Eighty-two adult liver transplant recipients were randomized into 2 groups: standard protocol group (n=41) in which steroids were withdrawn 3 months after the operation, and a 24-hour steroid avoidance group (n=41) in which steroids were eliminated within 24 hours. The incidence of acute rejections, infections (bacterial, fungal, and cytomegalovirus), and metabolic complications were analyzed between the groups.

Steroid elimination within 24 hours after orthotopic liver transplantation: effectiveness and tolerability.

Background: Steroids have been the mainstay of immunosuppressive regimen in liver transplantation. However, the use of steroids is associated with various post-transplant complications. This study evaluated the efficacy and safety of reduced immunosuppressive regimen with steroids (steroid elimination within 24 hours post-transplant) in a cohort of Chinese liver transplant recipients.

[A study of the efficacy and safety of using hepatitis B surface antigen-positive donors for liver transplantation].

Objective: To evaluate the outcomes of liver transplant recipients who received liver allografts from hepatitis B surface antigen (HBsAg)-positive donors.

Methods: The medical records of 23 male patients (median age, 42.5 years; range: 29-61) who received HBsAg-(+) liver allografts in our organ transplant center were retrospectively analyzed.

Sirolimus conversion in liver transplant recipients with calcineurin inhibitor-induced complications: efficacy and safety.

Objectives: To evaluate the efficacy and safety of conversion from calcineurin inhibitors to sirolimus among liver transplant recipients with calcineurin inhibitor-induced complications.

Materials And Methods: After receiving liver transplants, 25 patients with calcineurin inhibitor-induced complications (22 renal dysfunction and 3 new-onset diabetes mellitus) were converted from sirolimus to tacrolimus. The serum creatinine, sirolimus trough level, liver function, acute rejection episodes, and drug-related adverse effects were monitored.

[A 17-year study of bloodstream Escherichia coli infection after liver transplantation: resistance rate, risk factor and mortality].

Objective: To explore the resistance rate, risk factors and mortality of Escherichia coli bloodstream infections (BSI) after liver transplantation.

Methods: From January 1993 to May 2010, a retrospective analysis of Escherichia coli in liver transplants were conducted.

Results: A total of 88 BSI occurred in 83/695 patients and Escherichia coli (n = 23) was most commonly found.

[Clinical efficacies of ABO-incompatible adult liver transplantation].

Objective: To evaluate the efficacy and safety of ABO-incompatible liver transplantation in adult patients with fulminant hepatitis B.

Methods: The clinical data of 97 cases of adult liver transplantation for fulminant hepatitis B were retrospectively analyzed. The patients were grouped as ABO-identical (ABO-Id, n = 58), ABO-compatible (ABO-C, n = 19) and ABO-incompatible (ABO-In, n = 20).

[Experiences of liver retransplantation for postoperative diffuse biliary strictures].

Objective: To investigate the feasibility and management of retransplantation for diffuse biliary strictures occurring after initial liver transplantation.

Methods: The clinical data of 53 consecutive liver retransplantation patients at our hospital from January 2001 to December 2009 were collected and analyzed retrospectively. Among them, 20 (37.

[Analysis on treatment outcomes in five patients with combined en bloc liver and pancreas transplantation].

Objective: To summarize the treatment outcomes after combined en bloc liver and pancreas transplantation.

Methods: Five patients with end-stage liver disease and type 2 diabetes mellitus received combined en bloc liver and pancreas transplantation after hepatectomy.

Results: Five operations were performed successfully.

[Effect of Campath-1H induction on immunosuppression in small intestine transplantation].

Objective: To investigate the effect of Campath-1H induction on immunosuppression in small intestine transplantation.

Methods: Clinical data of a patient who underwent small intestine transplantation were retrospectively summarized.

Results: Intraoperative Campath-1H induction by intravenous injection was administered.

[A 17-year study of bloodstream infection after liver transplantation: resistance rate, risk factor and mortality of enterococcal bloodstream infections].

Objective: To explore the resistance rate, risk factor and mortality of enterococcal bloodstream infections (BSI) after liver transplantation.

Methods: From January 1993 to May 2010, a retrospective analysis of enterococcus in liver transplants were conducted.

Results: Fifty-eight BSI occurred in 53 of 695 patients.

[Clinical analysis on multivisceral transplantation].

Objective: To assess the indication, surgical and post-operative complications of the multivisceral transplantation.

Methods: The post-transplant complications of 8 patients who underwent multivisceral transplantation between May 2004 and May 2010 were analyzed. There were 7 male and 1 female, aged from 28 to 65 years.

[Evaluation of quality of life after simultaneous pancreas-kidney transplantation].

Objective: To evaluate the influence of simultaneous pancreas-kidney (SPK) transplantation on the quality of life of diabetic recipients with end-stage renal disease.

Methods: We performed a retrospective analysis of the data of diabetic patients with end-stage renal disease and evaluated the quality of life of the recipients using SF-36 health survey.

Results: One patient died of cerebrovascular accident, and 7 patients recovered smoothly.

[Application of steroids minimization immunosuppressive regimen in liver transplantation].

Objective: To investigate the safety and feasibility of steroids minimization immunosuppressive regimen in liver transplantation.

Methods: One hundred and sixteen patients in line with the selecting criteria from January 2005 to June 2008 were divided into three groups according to the withdrawal of steroids: 40 cases in 3 months withdrawal group, 40 cases in 7 d withdrawal group and the other 36 cases in 24 h withdrawal group. The difference of recipients' survival, infection, acute rejection and steroids resistant acute rejection, wound healing, recurrence of HBV and hepatocellular cell (HCC), new on-set of diabetes, hyperlipidemia and hypertension between the three groups were compared.

[Etiology and management of postoperative gastrointestinal bleeding after orthotopic liver transplantation].

Objective: To investigate the causes and treatment of postoperative gastrointestinal bleeding after orthotopic liver transplantation (OLT).

Methods: Clinical data of 776 patients after OLT between January 2000 and December 2006 were analyzed retrospectively.The experiences in diagnosis and treatment of postoperative gastrointestinal bleeding after OLT were reviewed.