Publications by authors named "Wei-Ming Tu"
Article Synopsis
- Researchers are developing nanomedicinal strategies to fight tumors but have not fully addressed the potential side effects of these treatments.
- A zebrafish xenograft model was created to study tumor growth and heart function simultaneously after administering different drug formulations.
- The study found that a new DOX-loaded nanocomposite reduced heart damage from the chemotherapy drug doxorubicin while still effectively inhibiting tumor growth, suggesting a promising assessment system for safer cancer treatments.
Autophagy is a self-protection process against reactive oxygen species (ROS). The intracellular level of ROS increased when cells were cultured under nutrient starvation. Antioxidants such as glutathione and ascorbic acid play an important role in ROS removal.
View Article and Find Full Text PDFWe synthesized a biothiol-sensitive nanoprobe by assembling gold nanoparticles with a novel redox-responsive silica (ReSi) matrix using dithiobis (succinimidyl propionate) and (3-aminopropyl) trimethoxysilane. Thin layer disulfide-bonded networks of the ReSi could differentially respond to extra- and intracellular glutathione in cancer cells within 30 min; furthermore, targeted cellular uptake could be monitored in situ by fluorescence recovery. Sigmoidal dose-response pattern of the nanoprobes presented in this study were attributed to the buried disulfide-linked 3D nanostructure of the ReSi nanoshell, optimized at an appropriate thickness, enabling not only buffering of small redox disturbances in the extracellular milieu but also the satisfied sensitivity for rapid redox sensing.
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