Publications by authors named "Wei-Min Shen"

Article Synopsis
  • The Kasabach-Merritt phenomenon (KMP) is linked to vascular tumors and involves low platelet counts and blood clotting issues; its cause and treatment are not well understood.
  • The study aimed to create an animal model of KMP by transplanting a piece of a Kaposiform hemangioendothelioma (KHE) tumor into nude mice, monitoring platelet levels and tumor characteristics over 16 weeks.
  • Results showed a significant drop in platelet counts shortly after transplantation, with a gradual recovery over time, and tumor analysis indicated changes in structure and composition, confirming the model's relevance for future KMP research and treatment development.
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The design, fabrication, and testing of an all-metal four-mirror telescope for high-resolution remote sensing is presented in this paper. The system works in the visible (VIS) band and is designed with a focal length of 1406 mm, an aperture of 200 mm, and a full field of view (FOV) of 1.32°.

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Background: Most of infantile hemangiomas involute into fibrofatty tissue in childhood, which indicates adipogenesis during this period. Mesenchymal stem cells (MSCs) contribute to the adipogenesis in IH. In this study, we investigated the effects of overexpression of PPAR-γ2 gene on the adipogenic differentiation of Hemangioma-derived MSCs (Hem-MSCs), and discussed the possibility of targeted therapy via PPAR-γ pathway.

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Infantile hemangioma, a common benign tumor of infancy, grows quickly in six months to one year after birth, then slowly involutes into fibrofatty tissue childhood. In this study, we observed the adipogenesis in hemangioma and investigated the expression of adipogenic differentiation-related genes. 33 fresh resected hemangioma samples were collected, including 18 proliferating cases (less than one year old), 9 involuting cases (from one to five years old), and 6 involuted cases (more than five years old).

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Kasabach-Merritt phenomenon (KMP) is life-threatening, charactered by the profound thrombocytopenia and consumptive coagulopathy associated with vascular tumors. The therapy of KMP still remains challenging. In this study, we retrospectively analyzed the clinical data of KMP treated in Nanjing Children's Hospital and Jinling Hospital, China, and brief reviewed the literature on KMP.

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Hemangioma-derived mesenchymal stem cells (Hem-MSCs) expressed PPAR-γ, the key transcription factor in adipogenesis. We supposed that rosiglitazone, the agonist of PPAR-γ, may promote the adipogenesis of Hem-MSCs. In this study, MSCs were isolated from proliferating hemangioma.

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A segmented structure optic fiber sensor is proposed and demonstrated; it is based on evanescent wave absorption theory. The waveguide modes of the segmented structure are simulated and analyzed by using the beam propagation method, which shows the high-order modes are excited repeatedly at the first transition of each segmented region. The effect of the number of segments and the core diameters on the sensitivity of the sensors is investigated experimentally.

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Infantile hemangioma, a common benign tumor of infancy, grows quickly in the first year of life, and then regresses slowly to fibrofatty tissue in childhood. The accumulation of fibrofatty tissue in hemangioma involution indicates adipogenesis during this period. Perivascular cells (PCs) from multiple organs display multi-lineage differentiation, including adipogenesis.

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Objective: To investigate the treatment of upper lip atrophy resulted by previous therapy.

Methods: From Mar. 2008 to Mar.

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Kaposiform hemangioendothelioma (KHE), a borderline tumor of endothelial origin, is associated with Kasabach-Merritt phenomenon, characterized by profound thrombocytopenia and consumptive coagulopathy resulting from the localized intravascular coagulation (LIC) in the tumor. Previous studies have suggested that the trapping of blood components, including platelets, may underlie the LIC in KHE. However, more evidence is needed to support this hypothesis.

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Objective: To investigate the role of the expression of PPAR-gamma gene in the adipogenesis in hemangioma evolution.

Methods: Routine immunohistochemistry staining of Perilipin A, the marker antigen of adipocytes, was performed to observe the adipogenesis in hemangioma. Immunofluorescence staining of PPAR-gamma, the important transcription factor in promoting adipogenesis, was carried out to observe its location in hemangioma tissue, with the co-staining of alpha-SMA and CD31.

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Objective: To investigate the diagnosis and mapagement of plagiocephaly resulted from For frontosphenoidal synostosis, frontosphenoidal synostosis and squamosal suture synostosis.

Methods: orthotic nolding therapy should be selected for patients under 3-month-old. If it can' t make effect after treatment for 3 months, transcranial surgery should be adopted with the horizontal advancement of orbitofrontal bar at the affected side.

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Objective: To discuss the segmental monobloc osteotomy and bi-directional distraction for the treatment of Crouzon syndrome in an infant.

Methods: A 9-month-old female infant underwent monobloc osteotomy through combined intra- and extra-cranial way. The facial skull was divided into frontal, orbital and maxillary segments.

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Infantile hemangioma grows quickly in the first year of life and regresses slowly to fibrofatty tissue during childhood; mesenchymal stem cells (MSCs) have been reported to contribute to this adipogenesis. Recent studies have shown the perivascular origin of MSCs in multiple organs. We hypothesized that MSCs in hemangioma might also reside in the perivascular region.

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Human error is one of the significant factors contributing to accidents. Traditional human error probability (HEP) studies based on fuzzy number concepts are one of the contributions addressing such a problem. It is particularly useful under circumstances where the lack of data exists.

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Objective: To discuss the diagnosis and treatment of children sinus pericranii (SP).

Methods: From Jan. 2000 to Dec.

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Objective: To investigate the management of congenital scalp defects in infants.

Methods: From 1996 to 2008, 6 infants with congenital scalp defects were treated with dressing change, flap transposition, or tissue expansion combined with skull defect reconstruction.

Results: Parietal scalp defects in 6 cases were healed after treatment.

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Objective: To investigate the feasibility of mandibular distraction osteogenesis (MDO) in the treatment of airway obstruction in Pierre Robin syndrome (PRS).

Methods: From 2007 to 2009, 8 newborns with PRS were treated with MDO. The mandibular distractors were fixed after bilateral oblique mandibular osteotomy.

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This paper presents a novel perspective of Robotic Stem Cells (RSCs), defined as the basic non-biological elements with stem cell like properties that can self-reorganize to repair damage to their swarming organization. Self here means that the elements can autonomously decide and execute their actions without requiring any preset triggers, commands, or help from external sources. We develop this concept for two purposes.

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Objective: To investigate the significance of 3-dimensional (3-D) CT for preoperative measurement and postoperative assessment in craniosynostosis.

Methods: 17 cases with craniosynostosis underwent 3-D CT reconstruction. The 3-D images were used to perform cephalometry.

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Objective: Treatments of unilateral lambdoid synostosis and unilateral coronal synostosis.

Methods: Approach to coronal, double frontal flaps were rotated with orbit advancement and anteversion of the frontal to enlarge the volume of ante cranial fossa., and reconstruct the contour of orbit and the frontal.

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Objective: To explore the effects of tetrandrine on inhibition of capsular contracture in rabbits.

Methods: 12 female New Zealand white rabbits were randomly divided into two groups with 6 animals in each group. Four smooth silicone implants (15 ml each) were implanted beneath the panniculus carnosus muscle of each rabbit.

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