FAM171B stabilizes vimentin and enhances CCL2-mediated TAM infiltration to promote bladder cancer progression.

Background: Invasion and metastasis are the main causes of unfavourable prognosis in patients diagnosed with bladder cancer. The efficacy of immunotherapy in bladder cancer remains suboptimal due to the presence of an immunosuppressive microenvironment. The novel protein family with sequence similarity 171B (FAM171B) has been identified, but its precise role and mechanism in bladder cancer remain unclear.

The ALOX5 inhibitor Zileuton regulates tumor-associated macrophage M2 polarization by JAK/STAT and inhibits pancreatic cancer invasion and metastasis.

5-lipoxygenase (encoded by ALOX5) plays an important role in immune regulation. Zileuton is currently the only approved ALOX5 inhibitor. However, the mechanisms of ALOX5 and Zileuton in progression of pancreatic cancer remain unclear.

Crizotinib and Doxorubicin Cooperatively Reduces Drug Resistance by Mitigating MDR1 to Increase Hepatocellular Carcinoma Cells Death.

As the sixth most lethal cancers worldwide, hepatocellular carcinoma (HCC) has been treated with doxorubicin (Dox) for decades. However, chemotherapy resistance, especially for Dox is an even more prominent problem due to its high cardiotoxicity. To find a regimen to reduce Dox resistance, and identify the mechanisms behind it, we tried to identify combination of drugs that can overcome drug resistance by screening tyrosine kinase inhibitor(s) with Dox with various HCC cell lines and .

Geniposide protection against Aβ toxicity correlates with mTOR inhibition and enhancement of autophagy.

Overactivation of the PI3-K/Akt/mTOR signaling pathway and inhibition of autophagy in the brain are involved in Alzheimer's disease. The present paper's goal was to explore the potential mechanisms of geniposide to protect against Alzheimer's disease. We treated the human neuroblastoma SH-SY5Y cell line with Aβ as an Alzheimer's disease model to explore the potential mechanisms of geniposide to protect against Alzheimer's disease.

Mild synthesis of isoxazoline derivatives via an efficient [4 + 1] annulation reaction of transient nitrosoalkenes and sulfur ylides.

An efficient [4 + 1] annulation between α-bromooximes and sulfur ylides via in situ generation of nitrosoalkenes under mild basic reaction conditions has been developed, providing an expeditious and scalable approach to synthesize biologically interesting isoxazoline derivatives with good to excellent yields.

Semaglutide-mediated protection against Aβ correlated with enhancement of autophagy and inhibition of apotosis.

Background: Semaglutide, a glucagon-like peptide-1 (GLP-1) analogue with an extended half-life of approximately 1 week has being come into clinic trial to treat parkingson's disease but little is known about its effect to prevent against Alzheimer's disease (AD). The goal of the present study was to explore the potential mechanisms of semaglutide to protect against AD.

Methods: We treated SH-SY5Y cell line with Aβ as an AD model.

Ligulaveitnoid A, a new phenylpropanoid from rhizomes and roots of .

A new phenylpropanoid, ligulaveitnoid A (), along with four known compounds, ()-2,3-dihydroconiferyl -coumarate (), dihydroconiferyl ferulate (), 4-hydroxy-3-methoxybenzaldehyde () and ()--coumaric acid () were isolated from rhizomes and roots of . All the structures of compounds were identified by the interpretation of their spectroscopic data and comparison with those reported in the literature. The anti-inflammatory activity of the isolates was examined for their inhibitory effects on LPS-induced NO production in macrophage RAW264.

[Roles of Mammalian Target of Rapamycin Signaling and Autophagy Pathway in Alzheimer's Disease].

The mammalian target of rapamycin(mTOR)is a serine/threonine protein kinase that regulates protein synthesis and degradation,cytoskeletal formation,and cell longevity.Autophagy,a catabolic process necessary for the maintenance of intracellular homeostasis,is essential for cell survival,whereas mTOR is the crucial regulator of autophagy.Alzheimer's disease(AD)is the most common cause of progressive dementia in the elderly.

Studies on optimum harvest time for hybrid rice seed.

Background: Timely harvest is critical for hybrid rice to achieve maximum seed viability, vigor and yield. However, how to predict the optimum harvest time has been rarely reported so far.

Results: The seed vigor of Zhuliangyou 06 (ZLY06) increased and reached the highest level at 20 days after pollination (DAP), when seed moisture content had a lower value, which was maintained until final seed maturation.

Physiological changes and sHSPs genes relative transcription in relation to the acquisition of seed germination during maturation of hybrid rice seed.

Background: During the production of early hybrid rice seed, the seeds dehydrated slowly and retained high moisture levels when rainy weather lasted for a couple of days, and the rice seeds easily occurred pre-harvest sprouting (PHS) along with high temperature. Therefore it is necessary to harvest the seeds before the PHS occurred.

Results: The seeds of hybrid rice (Oryza sativa L.

[Advances of NIR spectroscopy technology applied in seed quality detection].

Near infrared spectroscopy (NIRS) technology developed fast in recent years, due to its rapid speed, less pollution, high-efficiency and other advantages. It has been widely used in many fields such as food, chemical industry, pharmacy, agriculture and so on. The seed is the most basic and important agricultural capital goods, and seed quality is important for agricultural production.

Uterine arterial embolization in the management of severe post-partum hemorrhage: a successful rescue method to avoid peripartum hysterectomy.

Background: Although the effects of uterine arterial embolization (UAE) for the control of post-partum hemorrhage on menstruation, fertility and future pregnancy have been reported before, domestic reports on long-term outcomes are lacking.

Methods: From April 2001 to March 2005, 9 patients who underwent UAE for post-partum hemorrhage were evaluated retrospectively. The analyses included both immediate and long-term outcome, including menstruation, future fertility and subsequent pregnancies.

Dolabranes from the Chinese Mangrove, Ceriops tagal.

Six new dolabranes, named tagalsins P-U (1-6), were isolated from stems and twigs of a Chinese mangrove, Ceriops tagal, along with seven known dolabranes, an abietane, and a pimarane. The structures of these compounds were established on the basis of spectroscopic data or comparison with data in the literature. The relative configurations of tagalsins P and Q (1, 2), two new 15,16-dinor-dolabranes, were confirmed by means of single-crystal X-ray diffraction analysis.

Effect of S1P5 on proliferation and migration of human esophageal cancer cells.

Aim: To investigate the sphingosine 1-phosphate (S1P) receptor expression profile in human esophageal cancer cells and the effects of S1P5 on proliferation and migration of human esophageal cancer cells.

Methods: S1P receptor expression profile in human esophageal squamous cell carcinoma cell line Eca109 was detected by semi-quantitative reverse transcription polymerase chain reaction. Eca109 cells were stably transfected with S1P5-EGFP or control-EGFP constructs.

[RAPD analysis and construction of specific DNA probes between Pinellia ternata and Typhonium flagelliforme].

Objective: To establish a molecular marking method to identify Pinellia ternata and Typhonium flagelliforme.

Methods: Twenty-two random oligonucleotide primers were used in RAPD analysis on the genomic DNA of two types of Pinellia ternata in Sichuan and two types of Typhonium flagelliforme in Guangxi. The special fragments were sequenced, marked as probes and then conducted Southern blot.

Successful resection of a cervical pregnancy with original diagnosis of bladder wall invasion and rupture potential.

Objective: Cervical pregnancy is a rare life-threatening form of ectopic pregnancy. In the past, hysterectomy was often the only choice available because of profuse hemorrhage that accompanied the attempts of removal of the cervical pregnancy.

Case Report: We present a case of a successful surgical resection of a cervical pregnancy.

Recurrent breast cancer presents as a single solid ovarian mass and ascites.

Objective: Ovarian malignancy is highly suspected when patients present with an ovarian cystic mass lesion accompanied with ascites. However, aside from the primary origin, a metastatic lesion should be considered, since the ovary is frequently metastasized from cancers of other organs, such as the genital tract, gastrointestinal tract, and breast. Herein, we report the case of a patient with a left adnexal mass and ascites to emphasize consideration of metastatic ovarian tumors from non-gynecologic organs.

[Radiofrequency thermal ablation combined with arterial embolization for primary liver cancer].

Objective: To explore the short-term effect of radiofrequency ablation (RFA) combined with arterial embolization in treating patients with primary liver cancer.

Methods: Thirty patients with primary liver cancer received the combined treatment and the pre- and post-operative alpha-fetoprotein (AFP) levels, imaging features, and liver function were investigated along with observation of the incidence of complications to evaluate the therapeutic effects.

Results: The post-operative AFP positivity and the tumor density were significantly reduced in these patients, and their one-year survival rate reached 96.