Publications by authors named "Wei-Lin Qi"
This study developed a population pharmacokinetic model for sodium tanshinone IIA sulfonate (STS) in healthy volunteers and coronary heart disease (CHD) patients in order to identify significant covariates for the pharmacokinetics of STS. Blood samples were obtained by intense sampling approach from 10 healthy volunteers and sparse sampling from 25 CHD patients, and a population pharmacokinetic analysis was performed by nonlinear mixed-effect modeling. The final model was evaluated by bootstrap and visual predictive check.
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- A new assay using protein precipitation and liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been created and tested for measuring Sodium Tanshinone IIA Sulfonate (STS) in human plasma.
- The process involves adding an internal standard (DHEAS-D5) and using a specific mixture of acetonitrile and methanol for sample preparation, followed by detection through a specialized mass spectrometer.
- The method shows high accuracy and precision, with a calibration range of 2-1000 ng/mL and has been successfully used in a pharmacokinetic study with male volunteers in China.*
Gastrointestinal hemorrhage due to ileal metastasis from primary lung cancer.
World J Gastroenterol
March 2015
We report a patient with small intestinal metastasis from lung squamous cell carcinoma. A 66-year-old man who underwent radical lung cancer surgery was admitted to our hospital. Before starting his fifth cycle of chemotherapy, he was found to have a positive fecal occult blood test.
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