[Effect and mechanism of Gusong Qianggu Decoction on reducing bone loss in ovariectomized mice by targeting endoplasmic reticulum stress-induced apoptosis of osteocytes].

This study aims to investigate the role and mechanism of Gusong Qianggu Decoction(GSQG) in attenuating bone loss in ovariectomized mice by targeting the endoplasmic reticulum stress(ERS)-induced apoptosis of osteocytes. After the modeling of osteoporosis in mice with bilateral ovary removal(OVX), 60 mice were randomized by the random number method into six groups: sham,model, low-, medium-, and high-dose GSQG(GSQG-L, GSQG-M, and GSQG-H, respectively), and estradiol(E_2), with 10 mice in each group. The mice in each group were administrated with corresponding drugs by gavage one month after surgery and the administration lasted for 3 months.

Temperature effects in narrow-linewidth optical cavity control with a surrogate quasi-second-harmonic field.

Fabry-Perot cavities are widely used in precision interferometric applications. Various techniques have been developed to achieve the resonance condition via the direct interrogation of the cavity with the main laser field of interest. Some use cases, however, require a surrogate field for cavity control.

Optimized dielectric mirror coating designs for quasi-harmonic cavity resonance.

High-finesse optical cavities have a wide range of applications, some of which are bichromatic. The successful operation of high-finesse bichromatic cavities can demand careful control on the temperature dependence of the wavelength-dependent reflection phase from the dielectric mirror coatings that constitute the optical cavity. We present dielectric coating designs that are optimized for minimal differential change in the reflection phase between a quasi-second-harmonic field and its fundamental field under temperature changes.

Optics mounting and alignment for the central optical bench of the dual cavity enhanced light-shining-through-a-wall experiment ALPS II.

Any Light Particle Search II (ALPS II) is a light-shining-through-a-wall experiment seeking axion-like particles. ALPS II will feature two 120 m long linear optical cavities that are separated by a wall and support the same photon mode. The central optical bench at the core of the experiment will be equipped with a light-tight shutter and two planar mirrors for the cavities.

Coherently combined master oscillator fiber power amplifiers for Advanced Virgo.

Stable low-noise high-power lasers are indispensable in advancing the strain sensitivity of interferometric gravitational wave detectors. Advanced LIGO and Advanced Virgo are currently under commissioning and require about 200 W of single-frequency laser power, while the future detector design may require up to the order of 500 W. In this Letter, we present the design and, to the best of our knowledge, the first experimental demonstration of the laser system for Advanced Virgo that is based on coherently combined fiber laser amplifiers.

Layer-by-layer self-assembly of polydopamine/gold nanoparticle/thiol coating as the stationary phase for open tubular capillary electrochromatography.

Much attention has been paid to utilizing polydopamine (PDA) as the stationary phase in open-tubular capillary electrochromatography (OT-CEC) owing to its diverse properties, such as strong adhesion to various surfaces, latent reactivity toward amine and thiol groups and metal ion chelating/redox activities. In this study, a novel open-tubular capillary column coated with polydopamine/gold nanoparticles/thiols (PDA/Au NPs/thiols) has been fabricated based on the multiple properties of PDA for the first time. The capillary inner surface was firstly functionalized with a layer of PDA/Au NPs using the strong adhesive and metal ion redox properties of PDA.

[Total ginsenosides fought against right ventricular hypertrophy through inhibiting calcineurin signal pathway].

Objective: To observe the effect of total ginsenosides (TG) on monocrotaline (MCT) induced right ventricular hypertrophy rats, and to explore its correlation with calcineurin (CaN) pathway.

Methods: Fifty male Sprague Dawley rats were randomly divided into the normal control group, the MCT model group, and the low, middle, high dose TG treatment groups, 10 in each group. All medication was performed by peritoneal injection for 18 days.

[Effect of xuebijing injection on perioperative coagulation function and inflammatory reaction in senile patients receiving total hip arthroplasty].

Objective: To observe the effect of xuebijing Injection (XI) on perioperative coagulation and inflammatory reaction in senile patients receiving total hip arthroplasty (THA).

Methods: Totally eighty patients receiving THA at Luoyang Orthopedics Hospital, 65 to 85 years old, were randomly assigned to the control group (40 cases) and the treatment group (40 cases). All patients received routine perioperative therapies.

[Inhibitory effect of nitric oxide-induced total ginsenosides on right ventricular hypertrophy in rats].

Objective: To observe the effect of total ginsenosides (TG) on right ventricular hypertrophy induced by monocrotaline (MCT) in rats, and study its relationship with the nitric oxide pathway.

Method: Male Sprague Dawley rats were randomly divided into the control group, the MCT model group, TG-treated (20, 40, 60 mg kg-1 d-1) groups, and the L-arginine (L-arg) th NO release, T + L-N and L-a + L-N groups were wi th NOS into study TG's effect 200 mg kg-1 d-1 group. Besides, and its relationship wi also set, intraperitoneally injected with TG 40 mg kg-1 d -1 and L-arg 200 mg kg-1 - d-1, and orally administered hibitor L-NAME 20 mg kg-1 d-1.

Discrepancy between presumptive and definite causes of chronic cough.

Background: The current diagnostic algorithms for chronic cough require the establishment of the primary presumptive causes followed by the confirmation of diagnosis with the specific therapies. The aim of the study was to investigate the discrepancy between presumptive and definite causes and its clinical implication.

Methods: A total of 109 patients with chronic cough underwent laboratory investigations to identify the cause of cough; including sinus computerized tomography (if needed), histamine bronchial provocation, induced sputum cytology and 24-hour esophageal pH or multi-channel intraluminal impedance combined with pH monitoring.

Self-Assemblies of Single-Walled Carbon Nanotubes through Tunable Tethering of Pyrenes by Dextrin for Rapidly Chiral Sensing.

Pyrene-modified dextrin (Py-Dex) was synthesized via the Schiff base reaction between reducing end of dextrins and 1-aminopyrene, and then self-assemblies of single-walled carbon nanotubes (SWNTs) were fabricated through the tunable tethering of pyrene to SWNTs by dextrin chains. The Py-Dex-SWNTs assemblies were found to be significantly water-soluble because of the synergistic effect of dextrin chains and pyrene moieties. Py-Dex and Py-Dex-SWNTs were adequately characterized by NMR, UV-vis, fluorescence spectroscopy, Raman spectroscopy, matrix-assisted laser desorption/ionization-time of flight mass spectroscopy, and transmission electron microscopy.

[Changes in the spectrum and frequency of causes for chronic cough: a retrospective analysis].

Objective: To investigate the changing patterns of the spectrum and frequency of causes for chronic cough, and to explore its clinical implications.

Methods: Nine hundred and forty patients consecutively referred to Department of Respiratory Medicine for evaluation of chronic cough between January 2004 and December 2008 were collected and divided into 5 groups by periods of 5 years. The causes of cough had been primarily evaluated according to a step-by-step protocol and confirmed by the specific therapy.

The study of the interactions between heavy metals with sulfonylurea herbicides using ACE.

The affinity capillary electrophoresis method was used in the study of interactions between heavy metals (Pb, Mn, La, Cd, and Ni) and the sulfonylurea herbicides (thifensulfuron, nicosulfuron and sulfometuron). A buffer of 50 mM acetate (pH 5.85) was employed in the study.

Ultra-high concentration of amylose for chiral separations in capillary electrophoresis.

In the present study, a capillary electrophoresis method using high concentration of amylose solutions as separation medium has been developed with the aid of dimethyl sulfoxide (DMSO) as co-solvent. The best buffer conditions for primaquine, trihexyphenidyl (THP), sulconazole and cetirizine enantiomers were optimized as 20mM sodium phosphate buffer with DMSO/water (40/60, v/v) as solvent at a pH of 3.0, containing 10% (w/v) amylose.

Total ginsenosides inhibit the right ventricular hypertrophy induced by monocrotaline in rats.

Ginsenosides have been reported to release nitric oxide (NO) and decrease intracellular free Ca(2+) in cardiovascular system, which play important roles in antihypertrophic effect. This study investigated the potential inhibitory effect of total ginsenosides (TG) on right ventricular hypertrophy induced by monocrotaline (MCT, 60 mg/kg/d) and examined the possible antihypertrophic mechanism in male Sprague Dawley rats. MCT-intoxicated animals were treated with TG (20, 40, 60 mg/kg/d) for 18 d.

[A novel microemulsion electrokinetic chromatography for measuring lipid-water partition coefficients of pharmaceuticals].

Aims: To establish a novel microemulsion electrokinetic chromatography (MEEKC) method for measuring lipid-water partition coefficients ( logP(ow)) of pharmaceuticals without using microemulsion phase marker in order to avoid the error from tracing the migration time of microemulsion phase.

Methods: The migration time of microemulsion phase (t(me)) was obtained by non-linearity fitting with logP(ow) values from literature and measured migration time (t(m)) of a series of organic compounds, a calibration curve for estimating logP(ow) of pharmaceuticals was thus obtained. In addition, the accuracy of the values measured by MEEKC was evaluated.

Effects of phosphodiesterase 4 inhibitor on cough response in guinea pigs sensitized and challenged with ovalbumin.

Background: There is currently considerable interest in the potential value of selective inhibitors of cyclic nucleotide phosphodiesterase 4 in the treatment of asthma. However, whether they influence eosinophilic airway inflammation-associated cough remains unclear. The objective of this study was to investigate the effects of selective phosphodiesterase 4 inhibitor SB207499 on cough response and airway inflammation in guinea pigs sensitized and challenged with ovalbumin.