Convenient synthesis of -alkyl-3,1-benzoxazin-2-ones from carbamate protected anthranil aldehydes and ketones one-step alkylation/alkoxy rearrangement.

A practical and step-economical protocol was developed to prepare -alkyl-3,1-benzoxazin-2-one derivatives from anthranil aldehydes and ketones one-step alkylation/alkoxy rearrangement, where three new chemical bonds and one ring were constructed in a single step. Control studies revealed a stepwise mechanism and that the alkoxy rearrangement was an intermolecular process.

High expression of PPM1G is associated with the progression and poor prognosis of hepatocellular carcinoma.

Background: PPM1G, a member of the serine/threonine protease family, dephosphorylates various proteins and may be involved in cancer development. The role and mechanism of PPM1G in HCC still needs to be verified.

Objective: This study aims to explore the role of PPM1G in the occurrence, development and prognosis of HCC.

High Expression of SLC41A3 Correlates with Poor Prognosis in Hepatocellular Carcinoma.

Purpose: SLC41A3 is a member of the solute carrier family 41 (SLC41) and is involved in many cellular processes as a magnesium ion transporter. Although it plays an important role in cancer formation and development, the correlation between the expression of SLC41A3 and the occurrence and prognosis of hepatocellular carcinoma (HCC) remains unclear. Therefore, this study was focused on the evaluation of the relationship between SLC41A3 and the development and prognosis of HCC.

[Anterolateral acromial approach for the treatment of proximal humerus in 2-or 3-part fractures-a case-control study].

Objective: To explore the clinical curative effect of anterolateral acromial approach in treating two-and three-part of proximal humeral fractures.

Methods: Forty-two patients of proximal humeral fractures from January 2010 to June 2014 were analyzed retrospectively, including 23 males and 19 females with a mean age of 61.5 years old ranging from 40 to 76 years old.