The deubiquitinase USP34 stabilizes SOX2 and induces cell survival and drug resistance in laryngeal squamous cell carcinoma.

Recent studies showed that the deubiquitinase ubiquitin-specific protease 34 (USP34) was involved in the tumorigenesis of several tumors, but its function and mechanism are still unclear in laryngeal squamous cell carcinoma (LSCC). In this study, we found that USP34 and SOX2 were elevated in LSCC tumor tissues, and we also found that USP34 expression was positively correlated with SOX2 expression. Our further studies showed that USP34 regulated the protein level of SOX2 in LSCC cells, but not the mRNA level, which suggested that USP34 stabilized SOX2.

Electrochemical oxidation and advanced oxidation processes using a 3D hexagonal CoO array anode for 4-nitrophenol decomposition coupled with simultaneous CO conversion to liquid fuels via a flower-like CuO cathode.

A novel electrocatalytic system was developed to realize one-pot conversion of organic pollutants into liquid fuels such as methanol (CHOH) and ethanol (CHOH). The process combines the catalytic oxidation of organic pollutants with electrocatalytic reduction of CO. We first coupled the electrocatalytic process with SO-based advanced oxidation processes (AOPs) for the degradation of 4-nitrophenol (4-NP) using a 3D-hexagonal CoO anode.

[Clinical analysis of allergic rhinitis in children between 1 and 3 years of age].

Objective: To study the atopy spectrum and its related factors in 1 to 3 years old children with allergic rhinitis.

Methods: Ninety-six children with allergic rhinitis, aged between 1 and 3 years old, referred to ENT department of Beijing Children's Hospital between August 2009 and November 2010 were retrospectively reviewed. Data were recorded for patients' age, age stratification, sex, the age of first symptom, the duration of history, and the allergic history of children, the allergic history of parents.

A new registration method for three-dimensional knee nearthrosis model using two X-ray images.

The purpose of this study is to develop a method to analyse the pose of the knee nearthrosis mounted and to automate the registration procedure for easy use in clinical applications. The proposed registration method is essentially a model-based method, in which the CAD model is acquired by reverse engineering. The CAD model is converted into a two-dimensional (2D) image by a rendering technique, and the compatibility of the X-ray image and the image of the CAD model is investigated.

Sulforaphane protects immature hippocampal neurons against death caused by exposure to hemin or to oxygen and glucose deprivation.

Oxidative stress is a mediator of cell death following cerebral ischemia/reperfusion and heme toxicity, which can be an important pathogenic factor in acute brain injury. Induced expression of phase II detoxification enzymes through activation of the antioxidant response element (ARE)/Nrf2 pathway has emerged as a promising approach for neuroprotection. Little is known, however, about the neuroprotective potential of this strategy against injury in immature brain cells.