[Experimental studies on anti-mouse hepatocellular carcinoma effects of cisplatin combined with exosomes].

Aim: To study the anti-tumor effects and mechanisms of cisplatin(DDP) combined with exosomes.

Methods: The cell-growth inhibition of DDP on H(22); cells was analyzed by MTT assay.The mice were immunized by H(22); cell-derived exosomes.

[Effect of Janus kinase inhibitor AG490 on invasion and metastasis of human breast cancer cells].

Objective: To investigate the effect of Janus kinase (JAK) inhibitor AG490 on invasion and metastasis of the human breast cancer cell MDA-MB-231, and to explore the regulating role of JAK-STAT3 signaling pathway when the breast cancer occurs to the invasiveness and metastasis.

Methods: The human breast cancer cell MDA-MB-231 was used as the research object, and AG490 was as Janus kinase inhibitor. The adhesion of MDA-MB-231 cell attaching to matrigel was measured with MTT assay.

[Correlation of MUC1 expression to adhesion of breast cancer cell line MDA-MB-231].

Background & Objective: Recent researches found that an abundant production of mucin protein well correlates with tumor cell metastasis. This study was to investigate inhibitory effect of benzyl-alpha-GalNAc on production of mucin 1 (MUC1), and on adhesion and invasion of breast cancer cell line MDA-MB-231.

Methods: MDA-MB-231 cells were incubated with benzyl-alpha-GalNAc, expression of MUC1 was detected by immunohistochemistry, adhesive ability of MDA-MB-231 cells to artificial basement membrane Matrigel was measured by MTT assay.