Publications by authors named "Wei-Jiao Feng"
Article Synopsis
- Six new compounds called Euphohelinodes D-I (1-6), which are ent-abietane lactones, were discovered from the plant E. helioscopia, known for its anti-inflammatory properties.
- The structures of these compounds were analyzed using advanced techniques like spectroscopic data, X-ray diffraction, and ECD analysis.
- The most effective compound, euphohelinode H (5), reduced nitric oxide production in inflammatory cells and inhibited key enzymes linked to inflammation via the NF-κB signaling pathway, showing potential for treating inflammatory conditions.
Nine undescribed abietane diterpenoids (1-9) and eleven known abietane analogs (10-20) were isolated from Callicarpa bodinieri. Their structures were characterized by interpreting spectroscopic data, X-ray crystallography, and ECD analysis. The anti-inflammatory activities of these compounds were tested by evaluation of their inhibitory effect on NO production by lipopolysaccharide in RAW 264.
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- - Three new diterpenoids, pedilanins A-C, with a unique carbon structure, were discovered from the plant Pedilanthus tithymaloides, along with nine new jatrophane diterpenoids and five known compounds.
- - The newly identified compounds feature an unusual tricyclo[10.3.0.0]pentadecane skeleton and some jatrophanes have a rare cyclic hemiketal substructure.
- - In biological tests, these compounds significantly reversed multidrug resistance in cancer cells, showing improvements from 17.9 to 396.8 times at a concentration of 10 μM, primarily by inhibiting the P-glycoprotein transporter function.
Article Synopsis
- Researchers isolated 17 new diterpenoids, named phyllarheophols A-Q, from the plant Phyllanthus rheophyticus, along with 12 known compounds.
- The structural analysis of these compounds was conducted using spectroscopic techniques, single-crystal X-ray diffraction, and ECD analysis for accuracy.
- Anti-inflammatory effects were tested on macrophages, revealing that compounds phyllarheophol D and phyacioid B notably reduced cytokine levels and nitric oxide synthase via the NF-κB signaling pathway.
Article Synopsis
- Cardiac glycosides (CGs) are being studied as potential cancer treatments due to their diverse structures and strong biological effects.
- In the research, fifteen CGs were isolated from a plant, with three being new discoveries, and their structures were analyzed through various advanced scientific methods.
- The results showed that these CGs, particularly compound 1, had potent cytotoxic effects on cancer cell lines and interfered with the cell cycle, indicating potential for further development as cancer therapies.
Two new neolignans jatrolignans, C () and D (), a pair of epimers, were isolated from the whole plants of L. (Euphorbiaceae). Their structures were determined with HRESIMS, IR, and NMR data analysis, and electronic circular dichroism (ECD) experiments via a comparison of the experimental and the calculated ECD spectra.
View Article and Find Full Text PDFSixteen cardiac glycosides, including five previously undescribed compounds, were extracted and purified from whole plants of Calotropis gigantea (L.). Spectroscopic data and electronic circular dichroism (ECD) analyses were used to determine their structures.
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