Publications by authors named "Wei-Hua Shou"
Article Synopsis
- Graves' disease is an autoimmune disorder predominantly affecting females, with previous genome-wide studies not identifying X-linked susceptibility areas; however, this study analyzed new data by including males to investigate the X chromosome's role.
- A significant association was found at the Xq21.1 locus, specifically linked to the GPR174 gene, with a particular SNP (rs3827440) showing strong genetic correlation to the disease in both initial and independent validation samples.
- These findings highlight the involvement of the X chromosome in Graves' disease susceptibility and suggest that GPR174, expressed in immune tissues, could play a critical role in the disease's development.
Article Synopsis
- Northwest China, positioned near Central Asia, played a key role in the historic Silk Road facilitating east-west communication, but its population's genetic diversity remained largely unexplored.
- Researchers analyzed 503 male samples across 14 ethnic groups, using markers to reveal significant genetic variation among these groups, showing they are genetically closer to Central Asians than East Asians.
- The study indicates that the current populations are the result of mixing between early East Asians and later Central Asian migrants over the past 10,000 years, with limited West Eurasian genetic influence.
The tumor suppressor p53 is a master sensor of stress. Two human-specific polymorphisms, p53 codon 72 and MDM2 SNP309, influence the activities of p53. There is a tight association between cold winter temperature and p53 Arg72 and between low UV intensity and MDM2 SNP309 G/G in a cohort of 4029 individuals across Eastern Asia that suggests causative selection.
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