Discrepancies in neglected tropical diseases burden estimates in China: comparative study of real-world data and Global Burden of Disease 2021 data (2004-2020).

Objectives: To assess the discrepancies between real-world data and the Global Burden of Disease (GBD) 2021 estimates for six neglected tropical diseases in China. Additionally, to evaluate the applicability of the GBD model within the Chinese context and to assess the effectiveness of China's historical prevention and control policies for neglected tropical diseases.

Design: Comparative study of real-world data and GBD 2021 (2004-2020).

Fast measurement of coherence-orbital angular momentum matrices of random light beams using off-axis holography and coordinate transformation.

We propose an effective protocol to measure the coherence-orbital angular momentum (COAM) matrix of an arbitrary partially coherent beam. The method is based on an off-axis holography scheme and the Cartesian-polar coordinate transformation, which enables to simultaneously deal with all the COAM matrix elements of interest. The working principle is presented and discussed in detail.

Design, synthesis, and evaluation of 2,2'-bipyridyl derivatives as bifunctional agents against Alzheimer's disease.

Alzheimer's disease (AD) is a complex multifactorial neurodegenerative disease. Metal ion dyshomeostasis and Aβ aggregation have been proposed to contribute to AD progression. Metal ions can bind to Aβ and promote Aβ aggregation, and ultimately lead to neuronal death.

PLOD3 regulates the expression of YAP1 to affect the progression of non-small cell lung cancer via the PKCδ/CDK1/LIMD1 signaling pathway.

Procollagen-lysine, 2-oxoglutarate 5-dioxygenase (PLOD3) is a crucial oncogene in human lung cancer, whereas protein kinase C δ (PKCδ) acts as a tumor suppressor. In this study, we aimed to explore the regulation by PLOD3 on the expression of YAP1 to affect the progression of non-small cell lung cancer (NSCLC) via the PKCδ/CDK1/LIMD1 signaling pathway. We found that PLOD3, CDK1, and YAP1 were highly expressed, while LIMD1 was poorly expressed in NSCLC tissues.

Heat stress inhibits TLR4-NF-κB and TLR4-TBK1 signaling pathways in broilers infected with Salmonella Typhimurium.

With the global warming, the harm of heat stress (HS) to the breeding industry has become more common, which causes the decline of animal production performance and low immunity. This study aimed to analyze the effect of HS on the intestinal immune function of Salmonella-infected chickens. Fourteen-day-old broilers were divided into the following four groups of eight replicates: control (Control), heat stress (HS), Salmonella Typhimurium (ST), and heat stress + Salmonella Typhimurium (HS+ST).

High-Sensitivity Micro-Gas Chromatograph-Photoionization Detector for Trace Vapor Detection.

Rapid detection and analysis of trace vapor concentrations at a sub-parts per billion to parts per trillion level remains a challenge for many applications such as indoor air-quality analysis and detection of explosives and narcotics. Micro-gas chromatography (μGC) together with a micro-photoionization detector (μPID) is a prominent method for portable analysis of complex vapor mixtures, but current μPID technology demonstrates poor detection performance compared to benchtop flame ionization detectors (FIDs). This work demonstrates the development of a significantly improved μPID with a sub-picogram detection limit (as low as ∼0.

Heat stress inhibits expression of the cytokines, and NF-κB-NLRP3 signaling pathway in broiler chickens infected with salmonella typhimurium.

High ambient temperature has potential influence on oxidative stress, or systemic inflammation affecting poultry production and immune status of chickens. Heat stress (HS) induces intestinal inflammation and increases susceptibility of harmful pathogens, such as Salmonella and Escherichia coli. Intestinal inflammation is a common result of body immune dysfunction.

Heat stress aggravates intestinal inflammation through TLR4-NF-κB signaling pathway in Ma chickens infected with Escherichia coli O157:H7.

Heat stress can decrease poultry performance indices, immune function, and intestinal development, which can reduce birds' innate protective mechanisms and may be more susceptible for pathogens. Ma chickens heat-stressed with 41°C for 12 h and recovered for 7 d had extremely low immunity. In this study, a susceptible chicken model induced by heat stress and then infected with Escherichia coli O157:H7 was established to explore the mechanisms of birds' intestinal immune function changes.

Author Correction: Distribution pattern of leftventricular myocardial strain analyzed by a cine MRI based deformation registration algorithm in healthy Chinese volunteers.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Diverse Enzymes With Industrial Applications in Four Thraustochytrid Genera.

Thraustochytrids are heterotrophic fungus-like protists that can dissolve organic matters with enzymes. Four strains, AP45, ASP1, ASP2, and ASP4, were isolated from the coastal water of Taiwan, and respectively identified as sp., sp.

Left ventricular function recovery in peripartum cardiomyopathy: a cardiovascular magnetic resonance study by myocardial T1 and T2 mapping.

Background: Peripartum cardiomyopathy (PPCM) is rare and potentially life-threatening; its etiology remains unclear. Imaging characteristics on cardiovascular magnetic resonance (CMR) and their prognostic significance have rarely been studied. We sought to determine CMR's prognostic value in PPCM by using T1 and T2 mapping techniques.

Role of the overexpression of TRAF4 in predicting the prognosis of intrahepatic cholangiocarcinoma.

The incidence of intrahepatic cholangiocarcinoma (ICC) is progressively increasing worldwide, and its prognosis remains poor. Accumulating evidence has demonstrated that tumor necrosis factor receptor-associated factor 4 (TRAF4), an adaptor protein, is involved in the carcinogenesis and progression of several tumor types. However, the function of TRAF4 in predicting prognosis, and mediating migration and invasion of ICC remains to be elucidated.

Down-regulation of miR-30a-3p/5p promotes esophageal squamous cell carcinoma cell proliferation by activating the Wnt signaling pathway.

Aim: To investigate the potential role of microRNA-30a (miR-30a) in esophageal squamous cell carcinoma (ESCC).

Methods: Expression of miR-30a-3p/5p was analyzed using microarray data and fresh ESCC tissue samples. Both and assays were used to investigate the effects of miR-30a-3p/5p on ESCC cell proliferation.

[Reference Values for Left Ventricular Myocardial Strains Measured by Feature-tracking Magnetic Resonance Imaging in Chinese Han Population].

Objectives: To establish reference values for left ventricular (LV) myocardial strains in a cohort of healthy Chinese volunteers with feature tracking cardiac magnetic resonance imaging.

Methods: A total of 60 healthy volunteers were recruited, receiving a cardiac magnetic resonance imaging (CMR) examination at 3.0T scanner (Tim Trio, Magnetum, Siemens, Germany).

Distribution pattern of left-ventricular myocardial strain analyzed by a cine MRI based deformation registration algorithm in healthy Chinese volunteers.

The cine magnetic resonance imaging based technique feature tracking-cardiac magnetic resonance (FT-CMR) is emerging as a novel, simple and robust method to evaluate myocardial strain. We investigated the distribution characteristics of left-ventricular myocardial strain using a novel cine MRI based deformation registration algorithm (DRA) in a cohort of healthy Chinese subjects. A total of 130 healthy Chinese subjects were enrolled.

Effect of low-dose X-ray irradiation and Ti particles on the osseointegration of prosthetic.

Low-dose irradiation (LDI) exhibits a positive effect on osteoblasts and inhibitory effect of inflammation. Here, we test the hypothesis that LDI can promote osseointegration and inhibit the inflammatory membrane formation in the presence of titanium (Ti) particles. Endotoxin-free titanium particles were injected into rabbit, prior to the insertion of a Ti6-Al-4-V sticks pre-coated with hydroxyapatite.

Chromium level and intake from Chinese made tea.

Tea is a popular drink around the world. It is also one of the sources of metal intake. The objectives of this study were to assess chromium (Cr) intake from popular green, oolong, black and Pu-erh tea.

Benefits and risks from the national strategy for improvement of iodine nutrition: a community-based epidemiologic survey in Chinese schoolchildren.

Objective: Mild to severe iodine deficiency has been documented in China since 1960. To eliminate this persisting iodine deficiency, legislation on universal salt iodization was introduced in 1995 as a long-term public health intervention strategy. We examined the urinary iodine excretion and the iodine content of drinking water and salt samples to assess the benefits and risks of this national strategy.

Bruns-Cushing nystagmus due to hypertensive unilateral paramedian pontine base infarction.

Bruns-Cushing nystagmus is unusually rare and is known to be related with cerebellopontine angle tumor. A 32-year-old male patient came to our emergency department 3 times because of dizziness, right upper limb ataxia, hypertension, and Bruns-Cushing nystagmus. Magnetic resonance imaging demonstrated left paramedian pontine infarction.

One stage surgical correction of congenital cardiac disease and congenital tracheal stenosis in infants and children.

Objective: We describe our experience with patients undergoing one stage surgical correction of congenital cardiac disease and congenital tracheal stenosis.

Methods: Between February 2001 and June 2007, eight patients underwent one stage repair of congenital cardiac disease and congenital tracheal stenosis. Their ages ranged from 30 days to 3 years (mean 16.