Publications by authors named "Wei-Guo Lv"
Article Synopsis
- Platelets can be influenced by cancer through a process called education, leading to a specific transcriptional profile that can aid in cancer detection, particularly for ovarian cancer.
- A study involving 761 patients with confirmed adnexal masses and 167 healthy controls across multiple countries showed that tumor-educated platelets (TEPs) had a high diagnostic accuracy, with AUCs (area under the curve) ranging from 0.887 to 0.923 in validation cohorts.
- Combining TEPs with the CA125 biomarker further improved detection accuracy, and TEPs showed potential across diverse populations and cancer stages, but further extensive studies are necessary before they can be widely used in clinical settings.
Purpose: We aim to identify the methylation status of delta-like 1 (DLK1) in the placenta and the correlation between DLK1 methylation and maternal serum glucose level and fetal birth weight.
Methods: We analyzed the gene expression of DLK1 gene in both maternal and fetal sides of the placenta in a GDM group ( = 15) and a control group ( = 15) using real-time polymerase chain reaction. With MethylTargetTM technique, we detected the methylation status of DLK1 promotor in the placenta.
Type 2 Cesarean Scar Pregnancy Successfully Treated via Hysteroscopy-Assisted Laparoscopy.
J Minim Invasive Gynecol
May 2020
Study Objective: To evaluate the efficacy of hysteroscopy-assisted laparoscopy as a treatment strategy for type 2 cesarean scar pregnancy at gestational age >8 weeks.
Design: Retrospective case series (Canadian Task Force classification II-3).
Setting: A tertiary hospital.
Cervical cancer is the most common cause of cancer-related deaths in women from developing countries. Identification of novel prognostic predictors or therapeutic targets may improve patient prognosis. In the current study, we demonstrated by real-time PCR that miR-224 expression was significantly upregulated (1.
View Article and Find Full Text PDFEstablishing a Nomogram for Stage IA-IIB Cervical Cancer Patients after Complete Resection.
Asian Pac J Cancer Prev
February 2016
Background: This study aimed to establish a nomogram by combining clinicopathologic factors with overall survival of stage IA-IIB cervical cancer patients after complete resection with pelvic lymphadenectomy.
Materials And Methods: This nomogram was based on a retrospective study on 1,563 stage IA-IIB cervical cancer patients who underwent complete resection and lymphadenectomy from 2002 to 2008. The nomogram was constructed based on multivariate analysis using Cox proportional hazard regression.
Methotrexate induces apoptosis of human choriocarcinoma cell line JAR via a mitochondrial pathway.
Eur J Obstet Gynecol Reprod Biol
April 2009
Objective: To investigate methotrexate (MTX)-induced apoptosis and the involved pathways in human choriocarcinoma cells.
Study Design: MTX-induced apoptosis of human choriocarcinoma cell line JAR was examined using a PI/Annexin V stain with flow cytometer (FCM). Mitochondrial apoptosis was detected by fluorescence microscopy, and analyzed by FCM using a MitoCapture mitochondrial apoptosis detection kit.