Publications by authors named "Wei-Feng Deng"
Introduction: Alcoholic liver disease (ALD) is a global health problem for which there is no current food and drug administration (FDA)-approved therapy. Oenothein B (OEB) is a macrocyclic dimer ellagic tannin that possesses abundant biological activities including antioxidant, anti-inflammation, antitumor, immunomodulatory, and antimicrobial properties.
Materials And Methods: In this study, the hepatoprotective effect of OEB against ALD was investigated and .
Epidemiological and clinical evidences have shown that bone mineral density (BMD) has a close relationship with breast cancer (BC). They might potentially have a shared genetic basis. By incorporating information about these pleiotropic effects, we may be able to explore more of the traits' total heritability.
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- Bone mineral density (BMD) is influenced by genetics and is linked to coronary artery disease (CAD), suggesting a shared genetic basis known as pleiotropy.
- Using a new conditional false discovery rate (cFDR) method, researchers analyzed data from two large GWAS studies and discovered strong pleiotropic relationships, identifying 41 significant SNPs associated with lumbar spine (LS) BMD.
- The study confirmed the effectiveness of the cFDR method in detecting relevant genetic variants for BMD and provided insights into the genetic overlap between BMD and CAD, which could inform future research on bone health and heart disease.