Publications by authors named "Wei-Fan Ou"
Background: The radiology, obstruction, symptoms and exposure (ROSE) criteria provide a standardised approach for identifying the "COPD-bronchiectasis (BE) association." However, the clinical implications and outcomes of the COPD-BE association in East Asian populations remain unclear. Our study applied the ROSE criteria to assess the prevalence, clinical impact and outcomes of the COPD-BE association in an East Asian cohort, and compared that cohort with nonsmoking BE patients with fixed airflow obstruction (FAO) and those without FAO.
View Article and Find Full Text PDFBackground: Bevacizumab is extensively used in the treatment of advanced non-small-cell lung cancer (NSCLC). Numerous clinical trials have proven the clinical efficacies of bevacizumab biosimilars (BB).
Objective: Our study aimed to compare the clinical outcomes between bevacizumab reference product (RP) and BB among advanced NSCLC patients in a real-world setting.
Background: The administration of the COVID-19 vaccine has been linked to the development of herpes zoster (HZ). However, studies examining the clinical outcomes in COVID-19 vaccination-associated and non-COVID-19 vaccination-associated HZ are lacking.
Objective: To investigate the risk of postherpetic neuralgia (PHN) in COVID-19 vaccination associated HZ.
Background: In bronchiectasis, nontuberculous mycobacteria (NTM) lung disease (NTM-LD) is a well-known coexisting infection. However, microorganism coisolates and clinical NTM-LD predictors are poorly studied.
Methods: Patients with bronchiectasis diagnosed by means of computed tomography between January 2017 and June 2020 were screened, using the date of computed tomography as the index date.
Article Synopsis
- A cohort study investigated the impact of next-generation sequencing (NGS) on survival in advanced lung adenocarcinoma, including 424 patients divided into four treatment groups based on NGS testing timing and mutation status.
- Targetable mutations were found in 76.6% of treatment-naïve patients undergoing upfront NGS, with mutation-targeted therapies administered to a significantly higher percentage of these patients compared to those in other groups.
- Patients receiving mutation-targeted treatments showed improved overall survival, particularly in the upfront NGS group, highlighting the varying benefits and opportunities for NGS-based treatments across different patient populations.
Correlating Reiff scores with clinical, functional, and prognostic factors: characterizing noncystic fibrosis bronchiectasis severity: validation from a nationwide multicenter study in Taiwan.
Eur J Med Res
May 2024
Article Synopsis
- This study aimed to validate a simplified radiological scoring system for evaluating clinical symptoms and outcomes in Taiwanese patients with noncystic fibrosis bronchiectasis (NCFB).
- It involved analyzing data from 2,753 patients, assessing their bronchiectasis type and severity using a modified Reiff score derived from high-resolution CT scans, and correlating these with clinical features such as lung function and hospitalization rates.
- The findings indicated that as the severity of bronchiectasis increased, patients experienced worse symptoms and lung function, and identified factors like age and pneumonia as independent predictors of mortality, suggesting the scoring system's utility in clinical assessments.
Article Synopsis
- Acute respiratory distress syndrome (ARDS) is a serious condition, and this study focused on understanding its impact on older patients (aged 65 and above) compared to younger patients.
- Conducted at Taichung Veterans General Hospital in Taiwan, the study analyzed 728 patients, revealing that older patients had lower BMI and more comorbidities but similar mortality rates compared to younger patients, although they had longer ICU stays.
- Key risk factors for increased mortality in older patients included a BMI under 18.5, higher SOFA scores, and the severity of ARDS, indicating that these factors significantly affect their survival chances.
Background: Acute respiratory distress syndrome (ARDS) is a common life-threatening condition in critically ill patients. Itis also an important public health issue because it can cause substantial mortality and health care burden worldwide. The objective of this study was to investigate therisk factors that impact ARDS mortality in a medical center in Taiwan.
View Article and Find Full Text PDFBackground: Antiangiogenetic therapy and lung cancer, per se, are associated with an increased risk of thromboembolic events (TE). We aim to evaluate the pattern and outcome of TE as well as its influence on survival time of advanced non-small cell lung cancer (NSCLC) patients receiving antiangiogenic therapy.
Methods: This was a retrospective cohort study, which included advanced NSCLC patients receiving antiangiogenic therapy.
Background: We aim to evaluate the influence of the timing of leptomeningeal metastasis (LM) occurrence on the outcome of -mutant lung adenocarcinoma and to explore the predictors of detectable mutation in the cerebrospinal fluid (CSF).
Methods: -mutant lung adenocarcinoma patients with cytologically confirmed LM were included for analysis. mutation in CSF was detected by MALDI-TOF MS plus PNA.
Background: The long-term outcome is currently a crucial issue in critical care, and we aim to address the association between culture positivity and long-term mortality in critically ill patients.
Methods: We used the 2015-2019 critical care database at Taichung Veterans General Hospital and Taiwanese nationwide death registration files. Multivariable Cox proportional hazards regression model was conducted to determine hazard ratio (HR) and 95% confidence interval (CI).
Introduction: Multiple wasp stings is an emergency result from systemic reactions to the toxin with a wide range of manifestations, and we presented 2 patients with distinct clinical and transcriptomic findings.
Patient Concerns: Two patients without systemic disease presented with nearly 90 painful papules after attacked by a swarm of wasps (Vespa basalis).
Diagnosis: Patient 1 was a 44-year-old healthy male whose clinical manifestations mainly comprised hemolysis, hepatic injury, rhabdomyolysis, and acute kidney injury.