Publications by authors named "Wei-Chen Zhang"
Systemic chemotherapy improves outcome of hepatocellular carcinoma patients treated with transarterial chemoembolization.
Hepatobiliary Pancreat Dis Int
November 2024
Article Synopsis
- Transarterial chemoembolization (TACE) with or without tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs) is evaluated for its effectiveness as neoadjuvant therapy in hepatocellular carcinoma (HCC), focusing on the relationship between pathologic response and patient prognosis.
- In a study involving 481 HCC patients, 15.8% achieved complete pathologic response (CPR), and 37.2% reached major pathologic response (MPR), with improved median recurrence-free survival (RFS) noted in those achieving MPR or CPR.
- Analysis identified independent risk factors affecting recurrence-free survival, including failure to reach MPR, positive HBsAg, multiple lesions, and
Laparoscopic resection of a large primary pancreatic leiomyosarcoma (with video).
Hepatobiliary Pancreat Dis Int
September 2024
Objectives: Passive CLARITY is a whole-tissue clearing protocol, based on sodium dodecyl sulfate (SDS) clearing, for imaging intact tissue containing transgenic or immunolabeled fluorescent proteins. In this study, we present an improved passive CLARITY protocol with efficient immunolabeling without the need for electrophoresis or complex instrumentation.
Materials And Methods: In this experimental study, after perfusion of C57BL/6N mice with phosphate-buffered saline (PBS) and then with acrylamide-paraformaldehyde (PFA), the quadriceps femoris muscle was removed.
Synthesis and antitumor activity evaluation of asiatic acid derivatives as survivin inhibitor.
J Asian Nat Prod Res
September 2018
A series of asiatic acid derivatives were synthesized and their cytotoxicities in vitro against two cancer cell lines (HepG2 and SGC7901) were evaluated by MTT assay. The results showed that compounds I, I, and II have more potent anticancer activity than that of the positive control drug paclitaxel. The interactions between the compounds I, I, and II and survivin were also studied by docking simulations.
View Article and Find Full Text PDFEctopic lymphoid follicle infiltration is a key event in Hashimoto thyroiditis (HT). Positive regulatory domain zinc finger protein 1 (PRDM1), which is induced by antigen stimulation, can regulate all lymphocyte lineages. Several groups independently demonstrated that human parvovirus B19 (PVB19) is closely associated with HT.
View Article and Find Full Text PDF[Expression of Junctophilin 1 during cardiogenesis of mouse embryonic stem cells and rat embryos].
Zhejiang Da Xue Xue Bao Yi Xue Ban
July 2012
Objective: To investigate the expression of Junctophilin 1 (JP1) in cardiogenesis of mammalian.
Methods: Cardiac differentiation of embryonic stem cells (ESCs) was generated by hanging drop method. Fetal heart was obtained from the rats aged d 14-20 of gestation.