Publications by authors named "Wei-Bo Tian"
Neurochem Res
September 2024
Article Synopsis
- Idebenone is an antioxidant that appears to protect HT22 cells from oxidative stress by targeting CD38 to up-regulate SIRT3, which then deacetylates P53 and reduces apoptosis.
- The study utilized flow cytometry and TUNEL staining to confirm that Idebenone decreases levels of apoptosis and related proteins, specifically P53 and Caspase3, in HO-injured HT22 cells.
- Findings suggest that Idebenone could have therapeutic potential for neurodegenerative diseases like Parkinson's and Alzheimer's by mitigating oxidative damage associated with CD38-related disorders.
