Publications by authors named "Wei-Bo Le"
Article Synopsis
- * The study analyzed data from 168 patients with IMN and compared them to 36 patients with minimal change disease; results showed that those with positive PLA2R staining had lower coagulation times and higher coagulation indices.
- * Findings indicate that anti-PLA2R antibodies may contribute to hypercoagulability in IMN patients by affecting blood clotting factors like fibrinogen, thus providing
Background: Tripterygium Wilfordii Hook F (TwHF) preparation has been widely used in the treatments of IgA nephropathy (IgAN) in China. However, the effectiveness and safety of the new generation of TwHF preparation, KuxXian capsule, on the treatment of IgAN remains unknown.
Methods: Here, we retrospectively describe our experience treating 55 consecutive IgAN patients with KunXian.
Background: The urine protein-creatinine ratio (UPCR) in a spot first-morning urine sample is used to estimate 24-h urine proteinuria (24hUP) in patients who underwent urine protein testing. UPCR cannot be directly compared with 24-h proteinuria. Thus, an equation to estimate 24-h total protein excretion rate, using age, gender, and the UPCR may improve its bias and accuracy in patients who underwent urine protein testing.
View Article and Find Full Text PDFHLA Alleles and Prognosis of PLA2R-Related Membranous Nephropathy.
Clin J Am Soc Nephrol
August 2021
Background And Objectives: Associations between HLA alleles and susceptibility to M-type phospholipase A2 receptor (PLA2R)-related membranous nephropathy have been well defined previously in Chinese patients. However, the relationships between HLA alleles and kidney outcome remain unclear.
Design, Setting, Participants, & Measurements: Five HLA genes (DRB1, DQA1, DQB1, DRB3, and DRB5) were genotyped in a prospective cohort of 392 patients with PLA2R-related membranous nephropathy.
Objectives: To evaluate the changing spectrum of kidney diseases over time in China using renal biopsy-proven cases.
Methods: All patients over the age of 14 years who were diagnosed with a kidney disease by renal biopsy in the Renal Biopsy Registry of the National Clinical Research Center of Kidney Diseases in Jinling Hospital, Nanjing, from 2003 to 2014 were included.
Results: In total, 40,759 cases of renal biopsy were analyzed.
Background: Observational studies suggest that patients with immunoglobulin A nephropathy (IgAN) with active proliferative lesions show a good response to immunosuppressive treatment.
Study Design: Multicenter, prospective, randomized, controlled trial.
Setting & Participants: 176 patients with IgAN with active proliferative lesions (cellular and fibrocellular crescents, endocapillary hypercellularity, or necrosis), proteinuria with protein excretion ≥ 1.
Background: The KDIGO Clinical Practice Guidelines for Glomerulonephritis recommended tacrolimus as an alternative regimen for the initial therapy for Idiopathic membranous nephropathy (IMN), however, large observational studies evaluating tacrolimus treatment in IMN remains rare.
Methods: A total of 408 consecutive IMN patients with nephrotic syndrome who were treated with tacrolimus in Jinling Hospital were included. The effectiveness and safety of tacrolimus treatment in IMN were analyzed in this study.
Idiopathic membranous nephropathy (MN) is associated with HLA; however, the HLA allele involved remains unknown. To identify the HLA risk alleles associated with phospholipase A2 receptor (PLA2R)-related MN in the Chinese population, we sequenced the entire MHC region in DNA samples from 99 patients with PLA2R-related MN, 50 patients with PLA2R-unrelated MN, and 100 healthy subjects. Two HLA risk alleles, HLA-DRB1*15:01 and HLA-DRB3*02:02, independently and strongly associated with an increased risk of PLA2R-related MN.
View Article and Find Full Text PDFBackground: The association between psoriasis and membranous nephropathy (MN) remains largely unclear. We examined the prevalence of serum PLA2R antibody and characterized the expression of PLA2R and THSD7A in glomeruli in patients with MN and psoriasis.
Methods: A total of 24 patients with MN without evidence of a secondary cause except psoriasis were enrolled.
Serum phospholipase A2 receptor antibodies (SAbs) and glomerular phospholipase A2 receptor antigen (GAg) deposits have been observed in idiopathic membranous nephropathy (IMN). However, the clinical application of these two biomarkers, particularly GAg deposition, needs to be further evaluated. We measured SAb concentration by ELISA and GAg deposition by immunofluorescence in 572 patients with biopsy-proven IMN.
View Article and Find Full Text PDFArticle Synopsis
- The study compares the characteristics, treatment response, and outcomes of patients with IgA nephropathy and minimal change disease (MCD-IgAN) to those with classic minimal change disease (MCD).
- Both groups showed similar clinical symptoms, predominantly affecting young males with nephrotic syndrome, but MCD-IgAN patients had worse baseline kidney function and more severe kidney damage.
- After corticosteroid treatment, both groups had similar remission rates, and neither group progressed to end-stage renal disease during the follow-up period, although MCD-IgAN patients often required additional immunosuppressive treatment to achieve comparable outcomes.
Article Synopsis
- This study compares the characteristics and outcomes of patients with immunoglobulin A nephropathy and minimal change disease (MCD-IgAN) to those with immunoglobulin A nephropathy without minimal change disease (Non-MCD-IgAN).
- Results show that MCD-IgAN patients tend to be younger, experience less severe kidney damage, and have lower rates of end-stage renal disease (ESRD) compared to Non-MCD-IgAN patients.
- Overall, MCD-IgAN patients have a significantly better long-term renal prognosis, with only a small percentage reaching renal endpoints, unlike their Non-MCD-IgAN counterparts.
Background: Reversal of active glomerular lesions after immunosuppressive treatment in patients with IgA nephropathy (IgAN) and their association with prognosis have not been well established.
Methods: Sixty patients with IgAN who received repeat biopsies after immunosuppressive treatment were recruited. Reversal of renal pathological lesions was evaluated between the first and second biopsy.
Background/aims: The long-term renal outcomes of patients with IgA nephropathy (IgAN) who present with recurrent macroscopic hematuria (RMH) have not been described in previous studies.
Methods: Patients with biopsy-proven primary IgAN in Jinling Hospital were divided into three groups according to different patterns of macroscopic hematuria (MH): RMH, isolated MH (IMH), and those without a history of MH (NMH).
Results: A total of 1,155 patients were enrolled in the study (158 in the RMH group, 256 in the IMH group, and 741 in the NMH group).
Background: We sought to identify the long-term renal survival rate and related risk factors of progression to renal failure in Chinese adult patients with IgA nephropathy (IgAN) and to quantify the effects of proteinuria during the follow-up on outcome in patients with IgAN.
Methods: Patients with biopsy-proven primary IgAN in the Nanjing Glomerulonephritis Registry were studied. Renal survival and the relationships between clinical parameters and renal outcomes were assessed.
[Clinical characterization and outcome of patients with noncompaction of ventricular myocardium].
Zhonghua Xin Xue Guan Bing Za Zhi
June 2007
Objective: To analyze the clinical features and outcome of patients with noncompaction of ventricular myocardium (NVM).
Methods: Clinical manifestations, electrocardiograms and echocardiographies data were analyzed in 18 patients with NVM. Mean follow-up period was (11 +/- 5) months.