Publications by authors named "Wei-Bing Song"
Background & Aims: Liver injury is a common complication of heat stroke (HS), and often constitutes a direct cause for patient death. The cellular and molecular mechanism underlying HS-induced liver injury remains unclear. Recent evidence indicates that inflammasome plays an important role in mediating sterile inflammation triggered by tissue damage.
View Article and Find Full Text PDFAnti-inflammatory secoiridoid glycosides from Gentianella azurea.
Bioorg Med Chem Lett
November 2014
A phytochemical investigation on crude extract of Gentianella azurea led to the isolation of ten new (1-10) and one known (11) secoiridoid glycosides. Their structures were unambiguously elucidated by analysis of 1D and 2D NMR. Compounds 2, 5 and 11 were found to inhibit nitric oxide (NO) production in RAW 264.
View Article and Find Full Text PDFArticle Synopsis
- Curcumin has a protective effect on the intestinal mucosa barrier (IMB) and may help treat diseases caused by IMB dysfunction.
- Curcumin was shown to reduce harmful markers and promote protective ones in rat models, indicating its beneficial role in intestinal health.
- The mechanisms involve activation of MKP-1, inhibition of p38, and interference with the NF-κB signaling pathway, highlighting curcumin's potential as an anti-inflammatory and antioxidant agent.
Aim: To study the levels of serum soluble intercellular adhesion molecule-1 (sICAM-1), plasma D-lactate and diamine oxidase (DAO) in patients with inflammatory bowel disease (IBD), and the potential clinical significance.
Methods: Sixty-nine patients with IBD and 30 healthy controls were included in this study. The concentration of sICAM-1 was detected with enzyme-linked immunosorbent assay, the level of D-lactate and DAO was measured by spectroscopic analysis, and the number of white blood cells (WBC) was determined by routine procedure.
[Changyanqing decoction produces anti-inflammatory effect by inhibiting the activation of nuclear factor-kappaB].
Nan Fang Yi Ke Da Xue Xue Bao
July 2009
Objective: To detect the changes in intestinal mucosal permeation in rats with methotrexate-induced small intestinal damage and investigate the protective effects of Changyanqing decoction.
Methods: Rat enteritis model was established by methotrexate (MTX) and sodium chloride. The rats were randomly divided into normal control group, model group, N-acetylcysteine (NAC) group and Changyanqing decoction group, and Changyanqing decoction (100 mg/kg) or saline was administered daily in the corresponding groups by gastric irrigation for 6 days.
[Role of Rho-Rock pathways induced by angiotensin II in hepatic stellate cell contraction].
Zhonghua Yi Xue Za Zhi
September 2008
Article Synopsis
- The study aimed to uncover how Rho-kinase contributes to the contraction of hepatic stellate cells (HSCs) when stimulated by angiotensin II (Ang II) without relying on calcium pathways.
- HSCs were organized into different treatment groups that included a control group, Ang II exposure alone, and various inhibitors to examine specific pathways.
- Results showed that Ang II significantly increased the protein levels of phosphorylated myosin light chain (MLC), particularly peaking at 15 minutes, while inhibiting Rho-kinase or Ang II receptors reduced this phosphorylation compared to the Ang II group.
Objective: To investigate the effect of Changyanqing decoction, a traditional Chinese medicinal preparation, on the expressions of interleukin-10 (IL-10) and intercellular adhesion molecule-1 (ICAM-1) in the colon mucosa of rats with ulcerative colitis.
Methods: The rats with ulcerative colitis induced by trinitrobenzene sulphonic acid and ethanol enema were randomly divided into 3 groups, namely the model group, sulfasalazine (SASP) group, and Changyanqing decoction group. Daily treatment with intragastric administration and enema of normal saline, SASP (100 mg/kg), and Changyanqing decoction (39.
[Effect of angiotensin II on Rho-Rock pathway in rat hepatic stellate cell contraction].
Nan Fang Yi Ke Da Xue Xue Bao
June 2008
Objective: To investigate the mechanisms of angiotonin II (AngII)-induced Ca(2+)-independent pathways mediated by Rho kinase in hepatic stellate cells (HSCs).
Methods: HSC-T6 cells were treated with 1 micromol/L of AngII, and the subsequent cell contraction was directly observed with silicone rubber membrane culture method. The cells with 10 micromol/L AngII treatment were examined for myosin light chain (MLC) phosphorylation level using Western blotting, and the effects of irbesartan (a specific inhibitor of AngII 1- receptor) and Y27632 (a Rho kinase inhibitor) on AngII-induced MLC phosphorylation were evaluated.
[Protective effect of curcumin against methotrexate-induced small intestinal damage in rats].
Nan Fang Yi Ke Da Xue Xue Bao
January 2008
Article Synopsis
- The study aimed to investigate how methotrexate (MTX) affects intestinal mucosal permeability in rats and to explore the protective role of curcumin against this damage.
- Four groups of rats were used: a control group, a model group with induced enteritis, and two treatment groups receiving either sulfasalazine or curcumin. Results showed that the model group exhibited significant signs of intestinal damage, while curcumin treatment notably improved the condition.
- The findings suggest that MTX increases intestinal permeability, and curcumin may help protect against this effect by reducing the associated markers of intestinal damage.