The mediating role of medical coping modes between stigma and quality of life in patients undergoing lung cancer surgery: a cross-sectional study.

Background: Stigma has been identified as a significant factor impacting the health of lung cancer patients. However, the relationship between stigma, medical coping modes, and quality of life (QoL) has not been thoroughly examined.

Objective: This study aimed to explore the associations between stigma, medical coping modes, and QoL in patients undergoing lung cancer surgery.

Reproductive factors and risk of epithelial ovarian cancer: results from the Asia Cohort Consortium.

Background: There are scarce data on risk factors for epithelial ovarian cancer (EOC) in Asian populations. Our goal was to advance knowledge on reproductive -related risk factors for EOC in a large population of Asian women.

Methods: This study used pooled individual data from baseline questionnaires in 11 prospective cohorts (baseline years, 1958-2015) in the Asia Cohort Consortium.

Dissolution Behavior of M5 Cladding in Hydrofluoric-Nitric Mixed Acid.

M5 cladding has emerged as a prominent fuel cladding material due to its excellent corrosion resistance. The dissolution behavior of M5 cladding is critical in both the initial cleaning stage and the reprocessing of spent fuel cladding. This study investigated the dissolution of M5 cladding in hydrofluoric-nitric (HF-HNO) mixed acid at varying concentrations.

Protective Effects of Food-Derived Kaempferol on Pancreatic β-Cells in Type 1 Diabetes Mellitus.

Background: Kaempferol (KPF), a flavonoid abundant in edible plants, possesses potent anti-inflammatory and antioxidant properties beneficial with notable health benefits.

Objective: To evaluate the protective effects of KPF on metabolic disturbances and pancreatic damage in a Type 1 diabetes mellitus (T1DM) mouse model.

Methods: Male C57BL/6 mice were divided into normal, T1DM, T1DM + KPF 25 mg/kg, and T1DM + KPF 50 mg/kg groups.

Associations of Blood Lipid-Related Polygenic Scores, Lifestyle Factors and Their Combined Effects with Risk of Coronary Artery Disease in the UK Biobank Cohort.

Circulating lipids play a crucial role in the development of coronary artery disease (CAD). However, it is unclear whether the genetic susceptibility to hyperlipidemia may interact with lifestyle factors in CAD risk. Using UK Biobank data from 328,606 participants, we evaluated combined effects of genetic susceptibility to hyperlipidemia and lifestyle factors with risk of CAD.

Distinguishing Characteristics of Benign Versus Malignant Intraosseous Schwannomas: A Comparative Study.

Objectives: Benign and malignant intraosseous schwannomas are rare, and primarily documented in case reports. This study aims to elucidate the differences in clinical features and imaging manifestations between these tumors. This will help clinicians identify malignant lesions at an early stage, reliable guide treatment decisions, and accurately predict outcomes.

Evaluation of fission product yield distributions in the U(n, f) reaction.

In this work, the phenomenological potential-driving model based on the random neck rupture model is used to calculate and evaluate the independent yields and cumulative yields of fission products for the mass/charge distribution in the U(n, f) reaction with an incident neutron energy of 0.5 MeV and 14 MeV. In particular, the energy dependence of independent yields, including Kr, Sr, Zr, Mo, Ru, Xe, Cs, Ba and Ce, is evaluated for an incident neutron energy below 20 MeV and compared with GEFY6.

The 'roller coaster effect' in premolar extraction cases: clear aligners vs. straight-wire appliance.

Objectives: This study aimed to quantitatively investigate the intractable 'roller coaster effect' (RCE) that occurs in premolar extraction cases treated with clear aligner therapy (CAT) or straight-wire appliance (SWA).

Methods: Protrusion cases treated with extraction of bilateral first premolars were included. Pre- and post-treatment cephalograms were obtained to measure the bending angle of occlusal plane (BAOP), namely the occlusal intersection angle between the anterior occlusal plane (AOP) and posterior occlusal plane (POP).

Global research hotspots and trends in anti-inflammatory studies in dry eye: a bibliometric analysis (2004-2024).

Background: Inflammation plays a crucial role in the pathophysiology of dry eye (DE). This study aims to provide a comprehensive overview of the current status, hotspots and trends in DE anti-inflammatory research through bibliometric analysis.

Method: All publications were searched using the Web of Science Core Collection (WoSCC) database from 2004 to 2024.

The 2021 US Preventive Services Task Force lung cancer screening eligibility criteria disproportionately exclude younger Black patients with lung cancer.

Background: The 2021 US Preventive Services Task Force (USPSTF) lung cancer screening guideline may continue to exclude many younger Black individuals who have not yet accumulated enough smoking pack-years to be eligible for screening. The objective of this study was to evaluate the proportions of Black and White patients with lung cancer, stratified by age at diagnosis, who would have been eligible for lung cancer screening.

Methods: Incident lung cancer cases among Black and White individuals aged 50-80 years with a smoking history in the Southern Community Cohort Study (SCCS) were identified for analysis.

High Spatiotemporal Near-Infrared II Fluorescence Lifetime Imaging for Quantitative Detection of Clinical Tumor Margins.

Accurate detection of tumor margins is essential for successful cancer surgery. While indocyanine green (ICG)-based near-infrared (NIR) fluorescence (FL) surgical navigation enhances the visual identification of tumor margins, its accuracy remains subjective, underscoring the need for quantitative approaches. In this study, a high spatiotemporal fluorescence lifetime (FLT) imaging technology is developed in the second near-infrared window (NIR-II, 1000-1700 nm) for quantitative tumor margin detection, utilizing folate receptor-targeted ICG nanoprobes (FPH-ICG).

The Influence of Residential Segregation, Urbanicity, and Population Density on Hepatocellular Carcinoma Incidence among a Low Socioeconomic Population.

Background: Hepatocellular carcinoma (HCC) is becoming a leading cause of cancer-related mortality in the United States, with notable disparities observed among racial and ethnic minorities. The objective of this study is to examine the association between social determinants of health (SDoH) and HCC incidence by race (White and Black individuals) using data from the Southern Community Cohort Study (SCCS).

Methods: The SCCS is a prospective cohort study with participants recruited from 2002 to 2009.

Effect and mechanism of endoclip papilloplasty in reducing the incidence of cholelithiasis.

Background: Endoscopic sphincterotomy (EST) is widely used to treat common bile duct stones (CBDS); however, long-term studies have revealed the increasing incidence of recurrent CBDS after EST. Loss of sphincter of Oddi function after EST was the main cause of recurrent CBDS. Reparation of the sphincter of Oddi is therefore crucial.

Comprehensive profiling and identification of C21 steroids in the root of Marsdenia tenacissima (Dai-Bai-Jie) using offline two-dimensional chromatography (LC × SFC) with Q-TOF/MS.

Dai-Bai-Jie, the root of the plant Marsdenia tenacissima from the Asclepiadaceae family, is well-known for its therapeutic effects in clearing heat, detoxifying, reducing swelling, and relieving pain as one of the most commonly used Dai medicine. Due to numerous structurally similar C21 steroidal compounds in Dai-Bai-Jie, chemical composition profiling has been substantially challenged. In this study, an offline two-dimensional chromatographic method (LC × SFC separation system) was developed to address these issues.

Body mass index at birth and early life and colorectal cancer: A two-sample Mendelian randomization analysis in European and East Asian genetic similarity populations.

Background: Varying obesogenic inherited predisposition in early to later life may differentially impact colorectal cancer (CRC) development. Previous Mendelian randomization (MR) studies, conducted in populations of European genetic similarity, have not observed any significant associations between early life body weight with CRC risk. However, it remains unclear whether body mass index (BMI) at different early lifetime points is causally related with CRC risk in both Europeans and East Asian populations.