Histone variant H2A.Z is required for plant salt response by regulating gene transcription.

As a well-conserved histone variant, H2A.Z epigenetically regulates plant growth and development as well as the interaction with environmental factors. However, the role of H2A.

Life cycle, education, and statistical cognitive ability.

High statistical cognitive ability is an essential factor to achieve high-quality development in the era of artificial intelligence and big data. In this research, we use the machine learning local weighted regression algorithm to analyze the change curve of Chinese statistical cognitive ability throughout the life cycle, as well as the impact of individual education and parental education on statistical cognitive ability of 26,000 individuals from different groups of gender, age, educational background, and family background. All the data analyzed is from the China Family Panel Studies (CFPS).

A Plant-Based Dietary Supplement Improves Measures of Metabolic Detoxification and the Quality of Life: A Phase II Multicenter Randomized, Blinded, Placebo-Controlled Clinical Trial.

Background: Persistent accumulation and hindered clearance of toxins from tissues over time may promote the development and exacerbation of several diseases. Hepatic metabolic detoxification is a key physiological process responsible for the clearance of toxic substances from the body. A healthy diet with nutritional dietary supplementation may support metabolic detoxification and help mitigate the negative effects of toxin burden.

The importance of preoperative T3 stage substaging by 3D endorectal ultrasonography for the prognosis of middle and low rectal cancer.

Objective: The study aimed to validate the role of 3D-endorectal ultrasonography in prognosis and recurrence for patients with T3-stage rectal cancer by evaluating the preoperative extramural depth of tumor invasion.

Methods: In this study, we investigated the medical records of rectal cancer patients who were admitted to Changhai Hospital's Colorectal Surgery Division. The sample group was categorized into three subgroups (T3a, T3b, and T3c) based on the extent of tumor progression (<5 mm, 5-10 mm, and >10 mm) to assess the endorectal ultrasonography diagnostic performance.

Two New Species of Talaromyces Sect. Trachyspermi Discovered in China.

Two new species of sect. Trachyspermi isolated from soil are proposed, namely, T. albidus (ex-type AS3.

RP11-296E3.2 acts as an important molecular chaperone for YBX1 and promotes colorectal cancer proliferation and metastasis by activating STAT3.

Background: RP11-296E3.2 is a novel long noncoding RNA (lncRNA) associated with colorectal cancer (CRC) metastasis, that was reported in our previous clinical studies. However, the mechanisms of RP11-296E3.

Computed Tomography Image Analysis of Body Fat Based on Multi-Image Information.

Body fat assessment is required as part of an objective health assessment, both for nonobese and obese people. Image-based body fat assessment will enable faster diagnosis. Body fat analysis that accounts for age and sex will help in both diagnosis and correlating diseases and fat distribution.

[Community structure and diversity formation of fermentation fungi in traditional Shaoxing Huangjiu].

To reveal the formation mechanism of fungal community and diversity during the production of Shaoxing Huangjiu, we examined fungal communities in the samples of Linfanjiumu, Maiqu and fermentation mash based on Illumina MiSeq PE300 high-throughput sequencing platform. A total of 136000, 215283, 166150, and 143624 sequences were obtained from the samples of Linfanjiumu, Maiqu, initial mash and mature mash, respectively. After clustering, 32, 133, 107 and 84 OUT (operational taxonomic units) were obtained, respectively.

Implementation of virtual reality technology to decrease patients' pain and nervousness during colonoscopies: a prospective randomised controlled single-blinded trial.

Background: Improved patient satisfaction in endoscopy is worthy of study as it is an invasive and potentially uncomfortable procedure. There is growing literature on patient satisfaction assessment in endoscopy as part of improving quality assurance. This study aimed to determine whether virtual reality (VR) technology can decrease patients' pain and nervousness during colonoscopies.

The halophyte gene ScVTC2 confers resistance to oxidative stress via AsA-mediated photosynthetic enhancement.

Various abiotic stresses commonly cause excessive production of reactive oxygen species (ROS) and result in oxidative stress, which challenges the physiological homeostasis of plants. Maintaining a delicate balance between ROS generation and removal is critical for plants to cope with stressful environments. Suaeda corniculata is a typical euhalophyte with strong tolerance to salt stress, but its mechanism of ROS detoxification to prevent oxidative stress is unknown.

Analysis of the Curative Effect and Influencing Factors of Collagen Sponge Combined with Autologous Skin Graft in the Treatment of Deep Burn Patients.

Burn is one of the common traumatic diseases in clinics. After deep burn, the complicated changes of the condition are caused by the burn wound, which ends with the repair of the wound. For patients with deep burns, whether the wound can be repaired as soon as possible is the key to the success of clinical treatment.

A phase 1 study of LY3076226, a fibroblast growth factor receptor 3 (FGFR3) antibody-drug conjugate, in patients with advanced or metastatic cancer.

Background We report a Phase 1 study of LY3076226, an antibody-drug conjugate composed of human IgG1 monoclonal antibody against the human FGFR3 attached with a cleavable linker to the maytansine derivative DM4 in patients with advanced or metastatic cancer. Methods This study was comprised of two parts: (A) dose escalation in patients with advanced or metastatic cancer and (B) dose expansion in patients with urothelial carcinoma with locally determined FGFR3 alterations. The dose range of LY3076226 tested was 0.

Hydrogel-assisted delivery of lipophilic molecules into aqueous medium for transdermal medication based on environment-specific, regioselective adsorption of graphene oxides.

Graphene oxide (GO)-laden agarose composite hydrogels (GOACHs) were utilized to deliver lipophilic molecules from organic to aqueous media without alteration of the lipophilic nature of the molecules and the hydrophilic nature of the GOACHs. After the agarose host networks of the GOACHs were impregnated with the non-polar organic solution of lipophilic molecules via stepwise solvent exchange, their GO guests wielded the edge polar groups to effectively adsorb the lipophilic molecules via hydrogen bonding. After being transferred to aqueous media, the GOACHs were able to not only release the loaded lipophilic molecules but also to adsorb the released lipophilic molecules on the GO non-polar carbon lattice planes via hydrophobic interactions, thus resulting in deliberately balanced release of lipophilic molecules in aqueous media.

Nano Pd-Decorated Manganese Dioxide Nanosheets for Effective Photothermal Chemotherapy.

A drug delivery system based on the palladium and manganese dioxide composite (FP-Pd@MnO) is designed and prepared for the first time. The FP-Pd@MnO allows doxorubicin (DOX) loading as high as 58% in weight. The rapid release of DOX from FP-Pd@MnO is regulated via pH reduction, ascending glutathione concentration, and near-infrared (NIR) stimulus, which is advantageous to control drug release in the tumor site.

Synthesis and Evaluation of Aminothiazole Derivatives as Hedgehog Pathway Inhibitors.

A series of aminothiazole derivatives bearing the benzimidazole moiety were synthesized and evaluated in Gli luciferase reporter assays. Lead optimization led to the discovery of potent hedgehog pathway antagonist 18 (2-[3-(1H-benzimidazol-2-yl)-4-chloroanilino]-N-[4-(trifluoromethyl)phenyl]-1,3-thiazole-4-carboxamide), with IC values in nanomolar range. The molecular basis ascribed to hindering sonic hedgehog-driven Smoothened (Smo) localization within the primary cilium (PC).

[Interpretation of (WS/565-2017)].

Ascariasis once was a common disease in rural areas of China. It is showed that the average infection rate of in China was 1.36% according to the results of the national survey of important human parasitic diseases in 2015.

More Poop, More Precision: Improving Epidemiologic Surveillance of Soil-Transmitted Helminths with Multiple Fecal Sampling using the Kato-Katz Technique.

Soil-transmitted helminths, or parasitic intestinal worms, are among the most prevalent and geographically widespread parasitic infections in the world. Accurate diagnosis and quantification of helminth infection are critical for informing and assessing deworming interventions. The Kato-Katz thick smear technique, the most widely used laboratory method to quantitatively assess infection prevalence and infection intensity of helminths, has often been compared with other methods.

A practical community-based response strategy to interrupt Ebola transmission in sierra Leone, 2014-2015.

Background: The Ebola virus disease spread rapidly in West Africa in 2014, leading to the loss of thousands of lives. Community engagement was one of the key strategies to interrupt Ebola transmission, and practical community level measures needed to be explored in the field and tailored to the specific context of communities.

Methods: First, community-level education on Ebola virus disease (EVD) prevention was launched for the community's social mobilizers in six districts in Sierra Leone beginning in November 2014.

[SWOT Analysis of the National Survey on Current Status of Major Human Parasitic Diseases in China].

The National Survey on Current Status of Major Human Parasitic Diseases in China has been carried out since 2014 under the organization of the National Health and Family Planning Commission of the People's Republic of China. The National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (NIPD, China CDC) provided technical support and was responsible for quality control in this survey. This study used SWOT method to analyze the strengths, weaknesses, opportunities and threats that were encountered by he NIPD, China CDC during the completion of the survey.

[Analysis of capability of examining helminthes: National technique competition of parasitic disease diagnosis in 2013].

Objectives: To understand the ability of worm detection of staff of centers for disease control and prevention (CDC) in China, so as to promote the ability construction.

Methods: In each province, four competitors were selected from the institutions of parasitic diseases control to attend the National Technique Competition for Parasitic Disease Diagnosis and the results of competition were collected and analyzed.

Results: The average scores of microscopic identification and slide preparation of all the 124 competitors were 27.

[Molecular characteristics and RNA interference efficiency of Schistosoma japonicum Sj79 gene].

Objective: To study the structural features and characteristics of a novel gene Schistosoma japonicum 79 (Sj79), and observe its effect of RNA interference (RNAi) , so as to provide the experimental basis for its further function study and mechanism study of anti reproductive development of schistosome.

Methods: The gene structure and characteristics of Sj79 were analyzed by bioinformatics methods. Then the expressions of Sj79 messenger RNA (mRNA) during the different developmental stages of schistosome were analyzed and the effects of RNAi silencing were observed by the soaking method.

[Current situation of soil-transmitted nematodiasis monitoring in China and working keys in future].

Soil-transmitted nematodiasis is widely epidemic in rural areas in China. It was showed that the infection rate of soil-transmitted nematodes was 19.56% while the overall number of persons infected was 129,000,000, which was supported by the results of the National Survey of Current Situation of Major Human Parasitic Diseases in China in 2005 published by former Ministry of Health.

[Monitoring of Enterobius vermicularis infection among children from 2006 to 2010 and SWOT analysis].

Objective: To understand the infection status and variation tendeNcy of Enterobius vermicularis infection among children at national monitoring spots of soil-transmitted nematodosis from 2006 to 2010, and master the epidemic regularity, so as to provide the evidence for making control strategy and evaluating the control effect.

Methods: A total of 22 national monitoring spots of soil-transmitted nematodosis were established according to the National Surveillance Program of Soil-Transmitted Nematodiasis (Trial), and the children aged 3-12 years were examined through adhesive cellophane anal swabs, thenthe infection rates of children with different ages, genders, nationalities and education levels were analyzed. In addition, the advantage, disadvantage, opportunity and threat of the monitoring work were analyzed by SWOT analysis.