Intrinsic stimuli-responsive main-chain supramolecular polymers driven by dative B ← N bonds.

Novel main-chain supramolecular polymers (MCSPs) with intrinsic stimuli-responsiveness were developed using dative B ← N bonds. By separately fluoridating/defluoridating boron and protonating/deprotonating nitrogen, the resultant MCSPs show reversible intrinsic response.

GSDMD-mediated mitochondrial dysfunction in marginal cells: A potential driver of inflammation and stria vascularis damage in CIHL.

Inflammation is among the known causes of cisplatin-induced hearing loss (CIHL), but its exact pathophysiological mechanisms remain unclear. Herein, we demonstrated that pyroptosis-a recently identified inflammatory type of regulated cell death dependent on gasdermin D (GSDMD)-was activated in the cochleae of cisplatin-treated mice, causing CIHL. Meanwhile, treatment with the GSDMD inhibitor necrosulfonamide alleviated CIHL in these mice.

Aflatoxin B1 exposure induces Alzheimer's disease like pathology by disrupting redox homeostasis and activating ferroptotic signals in C57BL/6 J mice.

Aflatoxin B1 (AFB1) is one of the most toxic mycotoxins with neurotoxicity. Human exposure to AFB1 via contaminated foodstuffs has been linked to the risk of cognitive impairment, which may contribute to the progression of Alzheimer's disease (AD). However, the mechanism underlying the pathogenesis of AD in relation to AFB1 exposure is not clear.

A highland-adaptation variant near MCUR1 reduces its transcription and attenuates erythrogenesis in Tibetans.

To identify genomic regions subject to positive selection that might contain genes involved in high-altitude adaptation (HAA), we performed a genome-wide scan by whole-genome sequencing of Tibetan highlanders and Han lowlanders. We revealed a collection of candidate genes located in 30 genomic loci under positive selection. Among them, MCUR1 at 6p23 was a novel pronounced candidate.

Photothermally controlled ICG@ZIF-8/PLGA coating to modify the degradation behavior and biocompatibility of Zn-Li alloy for bone implants.

Biodegradable Zn alloy has recently gained attention for use in bone implants considering its biodegradability, attractive mechanical properties and bioactivity. However, excessive corrosion of Zn alloy at the early stage of implantation may cause severe cytotoxicity, resulting in insufficient osseointegration, which hinders the clinical use of Zn alloy. In this study, we designed a photothermally controlled degradative hybrid coating as a corrosion-protective barrier with the intention of preventing Zn ion burst release during the early stages of implantation and regaining the alloy's corrosion advantage later on.

A Multi-channel Eye-Mask-based Wearable System for Accurate Eye Movement Recognition and Saccadic Angle Estimation.

Advanced wearable systems can accurately capture eye movement patterns, providing users with precise, comfortable, and reliable HCI solutions. In this paper, a Multichannel Eye-mask-based Wearable (MEW) system that offers a portable, high-sensitive eye movement recognition (EMR) and saccadic angle estimation (SAE) via the combination of multi-channel eye-mask electrodes, high-precision EOG acquisition system, and automatic EMR and SAE algorithms is proposed. The multi-channel eye-mask electrodes provide high-spatial-resolution EOG sensing, and the high-precision EOG acquisition system leverages an STM32 microcontroller and a BLE transceiver for wireless EOG data transmission.

Default Mode Network, Disorganization, and Treatment-Resistant Schizophrenia.

Background And Hypothesis: Disorganized thinking is a prominent feature of schizophrenia that becomes persistent in the presence of treatment resistance. Disruption of the default mode network (DMN), which regulates self-referential thinking, is now a well-established feature of schizophrenia. However, we do not know if DMN disruption affects disorganization and contributes to treatment-resistant schizophrenia (TRS).

Evaluation of brain microstructure changes in surviving fetus of monochorionic twin pregnancies with single intrauterine fetal death using diffusion weighted imaging: a MRI-based cohort study.

Background: Single intrauterine fetal death (sIUFD) will lead to an increased risk of adverse events such as fetal brain abnormalities in the survivor. However, how to detect these anomalies in the early stages remains to be explored.

Objective: To compare apparent diffusion coefficient (ADC) values of fetal brain in cases of single intrauterine fetal death (sIUFD) with twins control and singleton control using diffusion weighted imaging (DWI), and to perform follow-up study to reveal the underlying cerebral microstructure changes.

Tracing impacts of prenatal exposure to bisphenol analogues on child anogenital distance development: A birth-cohort study.

Prenatal exposure to bisphenol analogues (BPs) is increasingly common and may affect children's reproductive development. However, human evidence is limited and inconsistent. Based on the Shanghai-Minhang Birth Cohort Study that enrolled participants in 2012 at Minhang Maternal and Child Health Hospital in Shanghai, China, we measured BPs in maternal urine samples collected during late pregnancy and children's anogenital distance (AGD: boys, AGD (anus-penis), AGD (anus-scrotum); girls, AGD (anus-clitoris), AGD (anus-fourchette)) from birth to 48 months as an indicator of reproductive development.

Application of small interfering RNA technology in cytochrome P450 gene modulation.

Cytochrome P450 plays key roles in the biotransformation of endogenous and exogenous chemicals including drugs and environmental pollutants. The inhibition and downregulation of P450s can have therapeutic effects, and/or modulate drug metabolism. P450s are largely inhibited by small molecules; however, this strategy is often hampered by intrinsic toxicity and drug-drug interactions.

Ligand Strategies for Regulating Atomically Precise CeO Nanoparticles: From Structure to Property.

The increasing interest in studying the structure-property relationships of ceria dioxide (CeO) relies on the fact that many factors are key to determining the performance of CeO materials. Despite the great advances achieved, it remains a formidable challenge to regulate CeO nanoparticles at the molecular level and gain in-depth insight into their structure-property relationships. What is reported here is a ligand strategy for regulating CeO nanoparticles, in terms of not only shape, structure, surface composition, but also property.

A dual-mode immunosensor for detection of oncoprotein c-Myc via indirect competition using trimetallic nanocomposite as an excellent label.

Background: The expression of oncoprotein c-Myc (OP) in blood is closely related to the occurrence and development of various tumors. Common detection methods have the disadvantages of complicated procedures, expensive instruments, or low sensitivity. Currently, several single-mode immunosensors have been developed to detect OP and overcome the above shortcomings.

Multiple Chemical Interactions in Additive Engineering of Perovskite for Enhanced Efficiency and Stability of Pure Blue Light-Emitting Diodes.

Additive engineering is extensively employed in perovskite light-emitting diodes (PeLEDs) to enhance the device performance. However, the effectiveness of additives is restricted, as they generally interact with only one or two components within the perovskite structure. Consequently, these additives are unable to fulfill the comprehensive functional requirements imposed by perovskite light-emitting materials.

Unmasking a Recessive Allele by a Rare Interstitial Deletion at 10q26.13q26.2: Prenatal Diagnosis of MMP21 -Related Disorder and Further Refine INSYN2A Involvement in the Postnatal Cognitive Phenotype.

Background: The 10q26 microdeletion syndrome (OMIM #609625) is a distinct genomic disorder characterized by a spectrum of clinical features including craniofacial anomalies, developmental delay (DD)/intellectual disability (ID), hypotonia, cardiovascular, and urogenital malformations. Despite the identification of critical regions within 10q26 linked to the syndrome's phenotype, the specific genes responsible for the associated facial characteristics, microcephaly, cognitive issues, and growth deficiencies remain elusive. Interstitial deletions at 10q25.

[Electroacupuncture relieves neuropathic pain-induced anxio-depression-like behaviors by regulating glutamatergic neurons in the ventrolateral orbital cortex of mice].

Objectives: To investigate whether electroacupuncture (EA) at "Yanglingquan" (GV34) and "Xuanzhong" (GB34) can alleviate anxio-depression-like behaviors induced by neuropathic pain and whether the effect of EA is in connection with the activity of glutamatergic neurons in the ventrolateral orbital cortex (VLO).

Methods: The neuropathic pain model was established by common peroneal nerve ligation (CPNL). GV34 and GB34 were selected in EA treatment (2 Hz/15 Hz, 1 mA), 15 min each time, once a day for 7 d.

Stealth Nanoparticles with a "Self-Consuming" Shell for Long-Term Blood Vessel Imaging.

The development of lanthanide-doped upconversion nanoparticle (UCNP)-based imaging with minimal autofluorescence and improved penetration depth is important in medical applications. Exogenous nanocarriers readily adsorb plasma proteins following intravenous administration (<0.5 min), resulting in the formation of a protein corona on the fixed surface.

kexB Gene Correlates With Aspergillus flavus Keratitis Severity: A Whole-Genome Analysis.

Purpose: Fungal keratitis caused by Aspergillus flavus (A. flavus) can result in severe inflammation and corneal stromal melting, leading to visual impairment. This study aimed to identify virulent genes correlated with the severity of A.

Maternal per- and polyfluoroalkyl substance concentrations and placental DNA methylation of thyroid hormone-related genes.

Studies suggested that per- and polyfluoroalkyl substances (PFAS) may have adverse effects on fetus by altering placental DNA methylation. In the study, we explored associations of maternal PFAS concentrations with placental DNA methylation of thyroid hormone (TH)-related genes and the potential mediating role of DNA methylation levels in PFAS-fetal TH associations. We measured PFAS concentrations in maternal plasma in early pregnancy and levels of total triiodothyronine (TT3), total thyroxine (TT4), free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH) in cord plasma.

Effect of SY009, a novel SGLT1 inhibitor, on the plasma metabolome and bile acids in patients with type 2 diabetes mellitus.

Context: As a novel SGLT1 inhibitor, SY-009 has been preliminarily confirmed in a phase Ib clinical study for its ability to reduce postprandial blood glucose in patients with type 2 diabetes mellitus (T2DM). However, the effects of SY-009 on human plasma metabolomics are still unknown.

Objective: This study aimed to explore the effects of SY-009 on plasma metabolomics in patients with T2DM and the potential metabolic regulatory mechanism involved.

Maternal per- and polyfluoroalkyl substances exposure, cord blood lipidomics and infant anthropometry: A mediation analysis.

Maternal exposure to per- and polyfluoroalkyl substances (PFAS) has been associated with offspring adiposity; however, underlying mechanisms remain unclear. In this study, we quantified 11 PFAS in maternal plasma collected between 12 and 16 gestational weeks and 104 lipid metabolites in the cord blood of 525 mother-infant pairs. Principal components of multiple PFAS compounds, extracted by principal component analysis, were employed to investigate the effect of the PFAS mixture.

Reducing oxygen-transport resistance within a catalyst layer for fuel cells by adopting an intrinsically microporous ionomer.

Herein, a sulfonated ionomer with intrinsic microporosity was designed as a catalyst binder in a low-Pt-loaded fuel cell to construct a good triple-phase boundary, achieving an obvious 57% reduction of local oxygen-transport resistance and a notable 47% increase in peak power density of up to 1233 mW cm.

Mechanism and Influencing Factor Analysis of Near-Well Stimulation for Hot Dry Rock Reservoirs by Liquid CO Phase Transition Blasting: Applied to Matouying Uplift.

To improve the heat transfer efficiency of the hot dry rock (HDR) well group, a near-well stimulation method of liquid CO phase transition blasting (LCO-PB) is put forward, the fracturing characteristics and mechanism of samples induced by impact dynamic load are analyzed, the effects of hydraulic fracturing cracks, buried depth, shock wave amplitude, and blasting frequency on the reservoir stimulation are clarified, and feasible suggestions have been proposed for its on-site application. Results show that the dynamic load applied by LCO-PB can effectively increase the number and connectivity of cracks and enhance the complexity of damaged cracks. The existence of hydraulic fracturing cracks has a promoting effect on the generation and distribution because blasting stress wave can reflect and refract in the hydraulic fracturing cracks and torn apart the surrounding area.

Temporal Association Cortex Gates Sound-Evoked Arousal from NREM Sleep.

Sound-evoked wakefulness from sleep is crucial in daily life, yet its neural mechanisms remain poorly understood. It is found that CaMKIIα+ neurons in the temporal association cortex (TeA) of mice are not essential for natural awakening from sleep. However, optogenetic activation of these neurons reliably induces wakefulness from non-rapid eye movement (NREM) sleep but not from rapid eye movement (REM) sleep.