Identifying PTAFR as a hub gene in atherosclerosis: implications for NETosis and disease progression.

Background: Atherosclerosis (AS) is a major cause of cardiovascular diseases and neutrophil extracellular traps (NETs) may be actively involved in the development of atherosclerosis. Identifying key biomarkers in this process is essential for developing targeted treatments for AS.

Methods: We performed bioinformatics analysis using a NETosis-related gene (NRGs) set and three AS datasets (GSE100927, GSE21545, and GSE159677).

Clinical Relevance of Discordance Between Physiology- and Imaging-Guided PCI Strategies in Intermediate Coronary Stenosis.

Background: Recent randomized clinical trials have demonstrated the benefits of intravascular imaging (IVI)-guided percutaneous coronary intervention (PCI) over angiography-guided PCI. However, the role of angiography-based physiological assessment during IVI-guided PCI remains unclear.

Objectives: This study aimed to explore the discrepancies and significance of angiography-based physiological assessments in IVI-guided PCI.

AutoFOX: An automated cross-modal 3D fusion framework of coronary X-ray angiography and OCT.

Coronary artery disease (CAD) is the leading cause of death globally. The 3D fusion of coronary X-ray angiography (XA) and optical coherence tomography (OCT) provides complementary information to appreciate coronary anatomy and plaque morphology. This significantly improve CAD diagnosis and prognosis by enabling precise hemodynamic and computational physiology assessments.

Multiscale Modeling of Heat Conduction in a Hydroxyethyl Cellulose/Boron Nitride Composite Realizing Ultrahigh Thermal Conductivity via a "Moisture-Activated" Strategy.

Polymer-based thermally conductive composites are widely used in microelectronics for heat dissipation and packaging, for which the filler arrangement and the filler/matrix interfacial thermal resistance (ITR) are key factors limiting superior thermal conduction realization. This work reveals the effects of filler modification and orientation on thermal duction in the boron nitride (BN)/hydroxyethyl cellulose (HEC) through multiscale simulation approaches. Nonequilibrium molecular dynamics (NEMD) identifies that the thermal conductivity of the BN molecule is not size-dependent and proves that thermal resistance is dramatically reduced after hydroxylation modification (BN).

Significant association between three atherosclerosis indexes and stroke risk.

Background: To evaluate the associations of three atherosclerosis indexes with stroke in a population aged 65 years and older.

Methods: A sample was obtained from wave 2011 to wave 2015 of the China Health and Retirement Longitudinal Study. Multivariate logistic regression models were used to estimate odds ratios (ORs) with 95% confidence intervals (CIs) for stroke in the quartiles of three atherosclerosis indexes, and restricted cubic splines were constructed.

An optimization model to prioritize fuel treatments within a landscape fuel break network.

We present a mixed integer programming model for prioritizing fuel treatments within a landscape fuel break network to maximize protection against wildfires, measured by the total fire size reduction or the sum of Wildland Urban Interface areas avoided from burning. This model uses a large dataset of simulated wildfires in a large landscape to inform fuel break treatment decisions. Its mathematical formulation is concise and computationally efficient, allowing for customization and expansion to address more complex and challenging fuel break management problems in diverse landscapes.

CD34CLDN5 tumor associated senescent endothelial cells through IGF2-IGF2R signaling increased cholangiocellular phenotype in hepatocellular carcinoma.

Introduction: The heterogeneity of hepatocellular carcinoma (HCC) is linked to tumor malignancy and poor prognosis. Nevertheless, the precise mechanisms underlying the development of the cholangiocellular phenotype (CCA) within HCC remain unclear. Emerging studies support that the cross-talk among the host cells within tumor microenvironment (TME) sustains the cancer cell plasticity.

Illuminating for purity: Photocatalytic and photothermal membranes for sustainable oil-water separation.

The integration of photocatalytic and photothermal materials with oil-water separation membranes marks a significant advancement in sustainable separation technologies. These hybrid membranes exhibit exceptional functionalities, including resistance to oil fouling, self-cleaning, antibacterial properties, and reduced oil viscosity. Based on their reaction mechanisms, current photocatalytic and photothermal membranes are categorized into four types, i.

Metformin activates the PI3K/AKT/BDNF axis to attenuate postoperative cognitive dysfunction.

Postoperative cognitive dysfunction (POCD) is a prevalent neurocognitive complication of anesthesia and surgery. Metformin, a widely used antidiabetic drug, has neuroprotective properties and improves cognitive impairment and memory deficits. However, the mechanisms underlying its action in improving cognitive dysfunction after anesthesia and surgery remain unclear.

Protective effect of trehalose on sperm chromatin condensation failure and semen quality decline in BDE-209-exposed mice.

BDE-209 exposure induced male reproductive toxicity with sperm quality decline. However, the role of autophagy in this was unclear. The purpose was to evaluate the protective effect and its potential mechanism of trehalose (Tre, autophagy inducer) on reproductive damage during spermiogenesis induced by BDE-209.

Enhanced hepatitis B virus-specific immunity by combined neutralizing antibody therapy and DNA vaccination in a murine model of chronic hepatitis B infection.

Background Aims: Successful treatment of chronic HBV infection remains a great challenge due to the difficulty in inducing efficient immune responses. Here, we investigated the therapeutic potential of DNA vaccination combined with a potent HBV broadly neutralizing antibody (bNAb) targeting the small surface viral antigen.

Approach Results: C57BL/6 mice were transduced with adeno-associated virus (AAV)-HBV and were treated twice a week with HBV bNAb for 5 weeks.

Associations between Multiple Food Consumption Frequencies and the Incidence of Cardiovascular Disease in High Cardiac Risk Subjects.

Background: Dietary choices are inextricably linked to the incidence of cardiovascular disease (CVD), whereas an optimal dietary pattern to minimize CVD morbidity in high-risk subjects remains challenging.

Methods: We comprehensively assessed the relationship between food consumption frequencies and CVD in 28,979 high-risk subjects. The outcome was defined as the composite of the incidence of major CVD events, including coronary heart disease and stroke.

Quantitative Conversion of Sulfate Oxygen for High-Precision Triple Oxygen Isotope Analysis.

Triple oxygen isotope composition (Δ'O) of sulfate carries information on the sulfur cycle as well as signatures of atmospheric O, O, and surface water of the geological past. However, existing analytical techniques can only achieve a partial oxygen yield during the conversion from sulfate to the analyte O, which results in isotope fractionation and impedes the Δ'O comparison with other oxygen-bearing compounds (e.g.

Multiresponsive Ionogel with Switchable Adhesion Triggered by Phase Separation.

The rapid development of wearable devices and soft robotics has an urgent demand for polymer conductors with a switchable adhesion property. Herein, we report a supramolecular ionogel (SIG) that can reversibly switch between adhesion and debonding to various substrates. The on/off switchable adhesion of SIG is attributed to phase separation induced by the aggregation of polymer chains and the formation of a lubricating layer, which impairs the contact between polymer chains and substrates, thus weakening interfacial interaction.

A Case of Thyroid Hormone Resistance Syndrome with a Novel Mutation (c.947G>a) in the Gene: Experience in Diagnosis and Treatment.

Background: Thyroid hormone resistance syndrome (RTH) is a rare hereditary endocrine disease that can manifest as hyperthyroidism, hypothyroidism, or remain asymptomatic. It can easily be confused with other types of thyroid diseases. The diagnosis of the disease depends on genetic testing.

Co-management enhances social capital and recognition of protected area: Perspectives from indigenous rangers on the Qinghai-Tibet Plateau.

Indigenous rangers play a critical role in achieving global biodiversity goals by facilitating effective conservation and community development. However, there is limited knowledge about rangers' livelihoods and responses to conservation policies. This study examined indigenous rangers' perceptions of livelihood impacts and attitudes toward national park management in Three-River-Source National Park (TRSNP).