Surgical anesthesia in a patient with a pheochromocytoma crisis supported by ECMO: a case report.

Pheochromocytoma is rare in clinical practice, with patients typically presenting with headache, high blood pressure and sweating. Patients who develop a pheochromocytoma crisis are particularly rare. This report describes the case of a patient in a pheochromocytoma crisis who presented with severe cardiogenic shock, acute respiratory failure, and acute coronary syndrome.

Cost-effectiveness of first-line systemic therapies for unresectable hepatocellular carcinoma.

Aims: To examine the cost-effectiveness of first-line systemic therapies recommended by the National Comprehensive Cancer Network guidelines for Unresectable Hepatocellular Carcinoma (uHCC) from the US social and payer's perspective.

Methods: A cost-effectiveness analysis was conducted using a three-state partitioned survival model to assess the cost-effectiveness of atezolizumab plus bevacizumab, tremelimumab plus durvalumab, durvalumab, lenvatinib and sorafenib as first-line treatments for uHCC. Clinical efficacy was derived from a published network meta-analysis.

A real‑world pharmacovigilance study of raloxifene based on the FDA adverse event reporting system (FAERS).

Background: Raloxifene was approved for the treatment of postmenopausal osteoporosis; however, its safety profile remains inadequately understood. This study aimed to evaluate the safety signals associated with raloxifene.

Research Design And Methods: Adverse events (AEs) related to raloxifene, spanning from the first quarter of 2004 to the fourth quarter of 2023, were extracted from the FDA Adverse Event Reporting System (FAERS) database.

Waterborne Polyurethane Treated with Flame Retardant Based on Polydimethylsiloxanes and Boron Phenolic Resin for Improving the Char Residue and Anti-Dripping Performance.

Waterborne polyurethane (WPU) was cured with a flame retardant composed of polydimethylsiloxanes and boron phenolic resin. In comparison to unmodified WPU, the heat resistance of the cured WPU film was significantly improved by approximately 40.0 °C, and the limited oxygen index (LOI) increased from 21.

Impact of Alkali Metals on CeO-WO/TiO Catalysts for NH-Selective Catalytic Reduction and Lifetime Prediction of Catalysts.

Ce-based catalysts have been widely used in the removal of nitrogen oxides from industrial flue gas because of their good catalytic performance and environmental friendliness. However, the mechanism of alkali metal poisoning in Ce-based catalysts remains to be further studied. This work involves the preparation of the K/Na-poisoned CeWTi catalyst via the impregnation method for assessing its performance in NO removal.

Long-Term Effects of a Comprehensive Intervention Strategy for Salt Reduction in China: Scale-Up of a Cluster Randomized Controlled Trial.

Salt intake in China was high and a series of salt reduction measures were accordingly carried out recently. Our study aimed to assess the long-term effect of a scale-up community randomized controlled trial (RCT); Methods: Individuals between the ages of 18 and 75, from six provinces in China, were recruited and randomized into control ( = 1347) and intervention ( = 1346) groups. A one-year salt reduction intervention was first implemented in the intervention group, followed by a two-year scale-up intervention in both groups.

Low serum S100A6 levels are associated RP-ILD risk in anti-MDA5-positive dermatomyositis.

Introduction: Anti-MDA5-positive dermatomyositis (anti-MDA5-DM) is a rare autoimmune disease that often leads to rapid-progressive interstitial lung disease (RP-ILD). The lack of effective prediction and treatment methods makes RP-ILD a major risk factor for death in patients with this condition. S100A6 is a member of the S100 Ca2 + - binding protein family, which plays important roles in inflammation, tumor, injury, and fibroblast reparation.

Safety and efficacy of inclisiran in treating hypercholesterolemia: A systemic review and meta-analysis.

Aims: To evaluate the efficacy and safety of inclisiran in the treatment of hypercholesterolemia.

Date Synthesis: Randomized controlled trials comparing inclisiran with a placebo were searched until April 2024. Overall, 8 studies involving 4947 patients were included.

A novel annexin dimer targets microglial phagocytosis of astrocytes to protect the brain-blood barrier after cerebral ischemia.

Despite the vital role of astrocytes in preserving blood-brain barrier (BBB) integrity, their therapeutic potential as targets in ischemic stroke-induced barrier disruption remains underexplored. We previously reported externalization of phosphatidylserine (PS) on astrocytic membranes concurrent with the emergence of PS externalization in neurons. PS externalization of astrocytes induced microglial phagocytosis of astrocytes, resulting in reduced astrocyte-vascular coupling and subsequent BBB breakdown.

Molecular typing and antimicrobial susceptibility profiles of Campylobacter jejuni and Campylobacter coli Isolates from Patients and raw meat in Huzhou, China, 2021-2022.

Background: Campylobacter species are zoonotic pathogens, and are considered to be the major foodborne pathogen that causes outbreaks and sporadic gastrointestinal illnesses both in developed and developing countries. In this study, the molecular typing and antimicrobial susceptibility profiles of Campylobacter jejuni and Campylobacter coli isolates from patients and raw meat between 2021 and 2022 in Huzhou were analyzed by using pulsed-field gel electrophoresis (PFGE), multilocus sequence typing (MLST) and antimicrobial susceptibility testing.

Methods: From September 1, 2021 to December 31, 2022, a total of 342 fecal specimens from diarrheal patients at a sentinel hospital in Huzhou and 168 samples of raw meat products collected from farmers' markets and supermarkets, were subjected to Campylobacter isolation and identification.

A 2-year pure biochar addition enhances soil carbon sequestration and reduces aggregate stability in understory conditions.

The enhancement of soil aggregate size and stability is crucial for mitigating climate change and improving carbon sequestration in forest ecosystems. Biochar, derived from rice husks, has been suggested as an effective mean to increase soil carbon storage. However, isolating biochar's specific effects on soil aggregate formation and carbon sink capacity can be complex due to the overlapping influences of fertilization and understory vegetation cultivation.

Carcinoma-Astrocyte Gap Junction Interruption by a Dual-Targeted Biomimetic Liposomal System to Attenuate Chemoresistance and Treat Brain Metastasis.

Brain metastasis contributes substantially to the morbidity and mortality of various malignancies and is characterized by high chemoresistance. Intracellular communication between carcinoma cells and astrocytes through gap junctions, which are assembled mainly by the connexin 43 protein, has been shown to play a vital role in this process. However, effectively blocking the gap junctions between the two cell types remains extremely challenging because of insufficient drug delivery to the target site.

Application of recombinase polymerase amplification with lateral flow assay to pathogen point-of-care diagnosis.

Since the outbreak of the new coronavirus, point-of-care diagnostics based on nucleic acid testing have become a requirement for the development of pathogen diagnostics, which require the ability to accurately, rapidly, and conveniently detect pathogens. Conventional nucleic acid amplification techniques no longer meet the requirements for pathogen detection in low-resource, low-skill environments because they require specialist equipment, complex operations, and long detection times. Therefore, recombinant polymerase amplification (RPA) is becoming an increasingly important method in today's nucleic acid detection technology because it can amplify nucleic acids in 20-30 minutes at a constant temperature, greatly reducing the dependence on specialist equipment and technicians.

Driving mechanisms of the spatial distribution of industrial parks and the relative hazard level of the surrounding environment.

Analyzing the formation mechanisms of industrial parks and quantitatively evaluating the related hazard levels are important for understanding the development and planning of industrial parks, but there is currently a lack of relevant research. In this study, Beijing was taken as a case study. The analysis results showed that (1) the overall spatial distribution of industrial parks in Beijing followed a clustering pattern, with nested spatial distribution pattern, where larger structures contributed 53.

Role of the mA demethylase ALKBH5 in gastrointestinal tract cancer (Review).

N6‑methyladenosine (mA) is one of the most universal, abundant and conserved types of internal post‑transcriptional modifications in eukaryotic RNA, and is involved in nuclear RNA export, RNA splicing, mRNA stability, gene expression, microRNA biogenesis and long non‑coding RNA metabolism. AlkB homologue 5 (ALKBH5) acts as a m6A demethylase to regulate a wide variety of biological processes closely associated with tumour progression, tumour metastasis, tumour immunity and tumour drug resistance. ALKBH5 serves a crucial role in human digestive system tumours, mainly through post‑transcriptional regulation of mA modification.

Organoids of Musculoskeletal System for Disease Modeling, Drug Screening, and Regeneration.

Musculoskeletal diseases have emerged as the leading cause of disability worldwide, with their prevalence increasing annually. In light of this escalating health challenge, organoids, an emerging technology in tissue engineering, offer promising solutions for disease modeling, drug screening, regeneration, and repair processes. The successful development of musculoskeletal organoids represents a significant breakthrough, providing a novel platform for studying musculoskeletal diseases and facilitating the discovery of new treatments.

Unravelling depth layers of microbial communities, nitrogen transformation rate, and extracellular polymeric substances in anammox granules.

Anammox granules harbor a variety of bacteria, with each granule layer providing a niche for bacteria with specific metabolic functions. To investigate microbial distribution, nitrogen transformation rates, and extracellular polymeric substance (EPS) content across the depth layers of anammox granules, granules sized 0.9-2.

Corrigendum: Integrated analysis of single-cell and bulk RNA sequencing data reveals a cellular senescence-related signature in hepatocellular carcinoma.

[This corrects the article DOI: 10.3389/fcell.2024.