Publications by authors named "Wei Xuan"

Probiotics are often subjected to adverse factors during processing, storage and digestion. To enhance the viability and function of probiotics, whey protein concentrate (WPC)-based microcapsules were systematically fabricated to co-encapsulate probiotic Lactiplantibacillus plantarum KLDS 1.0328 (LP KLDS 1.

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Global agricultural productivity is affected by plant stresses every year; as a consequence, monitoring and preventing plant stresses is a significant measure to protect the agro-ecological environment. Similar to the adoption of wearable devices to appraise human physiological information and disease diagnosis, however, in situ nondestructive monitoring of complex and weak physiological information in plants is an enormous challenge for the development of wearable sensors. Herein, to accurately analyze the changes of tomato internal information under multiple abiotic stresses in real-time, we introduce the covalent organic framework (COF) film synthesized by self-assembly layer by layer through the oil/water interface as a sensitive material to develop a multifilm-integrated wearable sensor capable of monitoring leaf surface humidity and leaf temperature.

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Objective: RS4;11 cell line was used to establish BCL-2 inhibitor-resistant cell lines of B-cell acute lymphoblastic leukemia (B-ALL) and explore the possible mechanisms of drug resistance.

Methods: RS4;11 cell line was continuously induced and cultured by low and ascending concentrations of BCL-2 inhibitors navitoclax and venetoclax to construct navitoclax-resistant cell line RS4;11/Nav and venetoclax-resistant cell line RS4;11/Ven. The cell viability was detected by MTT assay, and the cell apoptosis was detected by flow cytometry.

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Objective: To compare the clinical effects of total hip arthroplasty(THA) with and without femoral osteotomy in Crowe Ⅳ developmental hip dislocation(DDH).

Methods: The data on 46 patients who underwent THA for unilateral Crowe Ⅳ DDH between 2012 and 2017 were analyzed retrospectively. They were divided into two groups according to the different surgical methods.

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  • * Phylogenetic and structural analyses confirmed the naming of these CCRs, and their expression increased significantly in the spleen after bacterial infection, highlighting their importance in combating pathogens.
  • * Selection pressure analysis showed varying evolutionary pressures on these receptors, with molecular docking revealing potential ligand interactions for improved understanding of their functions in immune responses.
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  • - Persistent oxidative stress is linked to various chronic diseases like cancer, cardiovascular, and neurodegenerative disorders, highlighting its significance in health issues.
  • - Nrf2 is crucial for managing oxidative stress and inflammation, making it a promising target for preventing and treating these diseases.
  • - The review discusses advancements in understanding the Nrf2 pathway, current clinical trials on Nrf2 activators, and the role of natural products as potential therapies for chronic disease management from 2014 to now.
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Background: Sarcandra is one of the five genera of Chloranthaceae, which has a long history of medicinal use and high medicinal value, with excellent therapeutic effects on liver cancer, pneumonia, colitis, bone fractures, and dysentery. Among its species, Sarcandra glabra (Thunb.) Nakai has been extensively utilized in diverse compound formulations, toothpaste, tea, daily commodities, as well as health supplements.

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Plant root system is significantly influenced by high soil levels of ammonium nitrogen, leading to reduced root elongation and enhanced lateral root branching. In Arabidopsis, these processes have been reported to be mediated by phytohormones and their downstream signaling pathways, while the controlling mechanisms remain elusive in crops. Through a transcriptome analysis of roots subjected to high/low ammonium treatments, we identified a cytokinin oxidase/dehydrogenase encoding gene, CKX3, whose expression is induced by high ammonium.

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  • The study focuses on creating a diagnostic model to distinguish between benign and malignant pulmonary nodules to reduce mortality rates, as current methods are inadequate.
  • Researchers measured serum levels of specific biomarkers in 260 participants using advanced assays, optimizing a model that incorporates various patient and nodule characteristics for accurate risk assessment.
  • The developed model showed high accuracy in predicting malignancy, providing a tool for clinicians that can improve early detection and treatment of lung cancer, especially for patients with uncertain risk levels.
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  • The Chinese giant salamander is the largest living urodela species, and studying its immune system can provide insights into the evolution of vertebrate immune systems.
  • This study focused on characterizing the components of the NLRP3 inflammasome in the Chinese giant salamander, discovering that its genes share structural similarities with those in mammals.
  • Following infection with Aeromonas hydrophila, the expression of these genes was found to increase in various tissues, highlighting their role in the salamander's immune response and providing foundational knowledge for future research on the NLRP3 inflammasome.
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Nitrogen is an essential nutrient for plants and a major determinant of plant growth and crop yield. Plants acquire nitrogen mainly in the form of nitrate and ammonium. Both nitrogen sources affect plant responses and signaling pathways in a different way, but these signaling pathways interact, complicating the study of nitrogen responses.

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In an era characterized by rapid economic growth and evolving lifestyles, college students encounter numerous challenges, encompassing academic pressures and professional competition. The respiratory muscle endurance capability is important for college students during prolonged aerobic exercise. Therefore, it is of great significance to explore an effective intervention to enhance the endurance level of college students.

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Plastic nanoparticles are extensively used in various products, leading to inevitable pollution in soil. Understanding their transport in soils where various organic substances exist is crucial. This study examined the impact of low-molecular-weight organic acids (LMWOAs) on the transport of polystyrene nanoplastics (PS-NPs) through saturated quartz sand.

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Reyanning Mixture is one of the superior Chinese patent medicine varieties of "Qin medicine". Based on the idea of quality by design(QbD), the extraction process of the Reyanning Mixture was optimized. The caffeic acid, polydatin, resveratrol, and emodin were used as critical quality attributes(CQAs).

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  • * It utilizes a gold nanowire array combined with cadmium selenide quantum dots to enhance sensitivity, allowing detection of ALP at concentrations as low as 0.5 fM and cancer cells at 50 cells/mL.
  • * This platform enables high-resolution two-dimensional imaging of EGFR proteins on cancer cell membranes, showcasing its effectiveness for detailed cellular analysis.
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This study focuses on the prediction and management of carbon emissions (CE) under the backdrop of global warming, with a particular emphasis on developing spatial planning strategies for urban clusters. In this context, we integrate artificial intelligence technologies to devise an optimized spatial analysis method based on the attributes of multi-source, urban-level spatio-temporal big data on CE. This method enhances both the accuracy and interpretability of CE data processing.

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Phenotypic analysis has significant potential for aiding breeding efforts. However, there is a notable lack of studies utilizing phenotypic analysis in the field of edible fungi. is a lucrative edible fungus with significant market demand and substantial industrial output, and early-stage phenotypic analysis of is imperative during its breeding process.

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Neurological disorders, including brain injury, brain tumors, and neurodegenerative diseases, rank as the second leading cause of death worldwide. Exploring effective new treatments for neurological disorders has long been a hot research issue in clinical practice. Recently, microneedles (MNs) have attracted much attention due to their designation as a "painless and non-invasive" novel transdermal delivery method, characterized by their biocompatibility and sustainability.

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Excessive nitrogen promotes the formation of nonproductive tillers in rice, which decreases nitrogen use efficiency (NUE). Developing high-NUE rice cultivars through balancing nitrogen uptake and the formation of productive tillers remains a long-standing challenge, yet how these two processes are coordinated in rice remains elusive. Here we identify the transcription factor OsGATA8 as a key coordinator of nitrogen uptake and tiller formation in rice.

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Objectives: To establish age estimation models of northern Chinese Han adults using cranial suture images obtained by CT and multiplanar reformation (MPR), and to explore the applicability of cranial suture closure rule in age estimation of northern Chinese Han population.

Methods: The head CT samples of 132 northern Chinese Han adults aged 29-80 years were retrospectively collected. Volume reconstruction (VR) and MPR were performed on the skull, and 160 cranial suture tomography images were generated for each sample.

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Objective: Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease with high prevalence, morbidity, and mortality. Chuankezhi (CKZ) injection, a Chinese patent medicine, has been commonly used for treating COPD. This study evaluated the clinical efficacy of CKZ injections in COPD patients and explored potential underlying mechanisms by integrating meta-analysis and network pharmacology.

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Article Synopsis
  • * A-kinase anchoring proteins (AKAPs) help organize cell signals and are important for brain health, but their role in strokes isn’t fully understood yet.
  • * The review looks at how AKAPs are linked to different health issues that can cause strokes and suggests they might be good targets for new treatments.
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A typographical error has appeared in the ethical acceptance number in the manuscript titled "An 88-year-old Man with Rare Giant Liposarcoma of the Scrotum", 2024; 20: e310823220564 [1]. Original: This study was approved by the ethics committees of Beijing Friendship Hospital, Capital Medical University (2023- P2-110-02) and conducted by the Declaration of Helsinki. Corrected: This study was approved by the ethics committees of Beijing Friendship Hospital, Capital Medical University (2024- P2-073) and conducted by the Declaration of Helsinki.

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C-terminally encoded peptides (CEPs) are peptide hormones that function as mobile signals coordinating crucial developmental programs in plants. Previous studies have revealed that CEPs exert negative regulation on root development through interaction with CEP receptors (CEPRs), CEP DOWNSTREAMs (CEPDs), the cytokinin receptor ARABIDOPSIS HISTIDINE KINASE (AHKs) and the transcriptional repressor Auxin/Indole-3-Acetic Acid (AUX/IAA). However, the precise molecular mechanisms underlying CEPs-mediated regulation of root development via auxin and cytokinin signaling pathways still necessitate further detailed investigation.

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Xing 9 Ling tablet candy (X9LTC) effectively treats alcoholic liver disease (ALD), but its potential mechanism and molecular targets remain unstudied. We aimed to address this gap using network pharmacology. Furthermore, high-performance liquid chromatography (HPLC) and database analysis revealed a total of 35 active ingredients and 311 corresponding potential targets of X9LTC.

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