Effect of polysaccharides and saponins from Polygonatum kingianum against uranium-induced renal injury in rats.

Uranium poisoning is increasingly recognized as a public health issue. Polygonatum kingianum (PK) is valued for its therapeutic properties and food applications. Original research showed PK aqueous extract (PKAE) and polysaccharides (PKP) could alleviate uranium-induced cytotoxicity in vitro.

Effect of persulfate dosage on organic degradation using N-doped biochar: Reaction pathway and environmental implications.

Persulfate-based advanced oxidation processes (PS-AOPs) catalyzed by carbon-based catalysts are promising for removing organic pollutants via radical/non-radical pathways. However, the activation efficiency of peroxymonosulfate (PMS) or peroxydisulfate (PDS) usage and the reaction mechanism remain insufficiently understood. In this study, the effects of PMS/PDS dosage on the degradation of bisphenol A (BPA, 10 mg/L) were evaluated using N-doped biochar (N-BC, 0.

Impact of transcutaneous auricular vagus nerve stimulation on postoperative pain in patients undergoing perianal surgery: a randomized trial.

Objective: This study aims to evaluate the effectiveness of transcutaneous auricular vagus nerve stimulation (taVNS) on postoperative pain in patients following perianal surgery.

Methods: 96 patients were randomly assigned to either the taVNS group or the sham stimulation group. Patients received stimulation once 30 min before the operation and once more 24 h after the operation, with each session lasting 30 min.

Extracting the Luttinger Parameter from a Single Wave Function.

The low-energy physics of Tomonaga-Luttinger liquids (TLLs) is controlled by the Luttinger parameter. We demonstrate that this parameter can be extracted from a single wave function for one-component TLLs with periodic boundary condition. This method relies on the fact that TLLs are described by conformal field theory in which crosscap states can be constructed.

High-Adhesive Hydrogel-Based Strain Sensor in the Clinical Diagnosis of Anterior Talofibular Ligament Sprain.

Anterior talofibular ligament (ATFL) sprain is one of the most prevalent sports-related injuries, so proper evaluation of ligament sprains is critical for treatment options. However, existing tests suffer from a lack of standardized quantitative evaluation criteria, interindividual variability, incompatible materials, or risks of infection. Although advanced medical diagnostic methods already have been using noninvasive, portable, and wearable diagnostic electronics, these devices have insufficient adhesion to accurately respond to internal body injuries.

Inter-organelle communication dynamically orchestrates juvenile hormone biosynthesis and female reproduction.

Inter-organelle communication coordinates cellular homeostasis and function. Juvenile hormone (JH) is produced in the corpora allata (CA) and acts as a gonadotrophic hormone in most insects. Using transcriptomic, biochemical, molecular, and genetic analyses, here we investigated the underlying mechanism of how inter-organelle communication dynamically orchestrates JH biosynthesis and female reproduction in the American cockroach, .

Friction-induced pain: from skin surface to brain activation.

The interface friction between prosthetic socket and residual limb tends to cause skin injury and pain. The frictional pain was systematically studied based on skin tribological behaviors and brain activation. The results showed that the skin frictional pain was affected by the combination of friction and mechanical properties of anatomic regions and liner materials.

Zebularine showed anti-tumor efficacy in clear cell renal cell carcinoma.

Background: Clear cell renal cell carcinoma (ccRCC) has the highest morbidity among renal cell carcinoma (RCC) subtypes. While existing clinical pharmacological intervention strategies have achieved certain efficacy, challenges including inevitable drug resistance and intricate immune heterogeneity of ccRCC continue to hinder their biomedical application. Therefore, developing novel immunotherapeutic agents and identifying patients who can gain the greatest benefits from these therapies are urgent issues.

Oncofertility Barriers in Nurses Caring for Women with Breast Cancer.

Despite the importance of oncofertility care in supporting women coping with fertility challenges after breast cancer, the practice of oncofertility care among nurses remains suboptimal. There is an urgent need to investigate oncofertility barriers faced by nurses caring for women with breast cancer. A cross-sectional online study was conducted among registered nurses caring for women with breast cancer.

Exploration of biomass fractionation and lignin removal for enhancing enzymatic digestion of wheat-stalk through deep eutectic solvent Cetyl trimethyl ammonium chloride:Lactic acid treatment.

The cationic surfactant-based deep eutectic solvents (DESs) have attracted extensive attention due to their effectual destruction of the natural anti-degradation barrier structure in lignocellulose. In this research, functional DES Cetyl trimethyl ammonium chloride:Lactic acid (CTAC:LA molar ratio 1:0.5 to 1:6) was fabricated for pretreating wheat-stalk.

Interplay of gut microbiota in Kawasaki disease: role of gut microbiota and potential treatment strategies.

Kawasaki disease (KD) is an acute systemic immune vasculitis with predominant involvement of the medium and small arteries. It mostly affects pediatric patients, representing the most common form of pediatric vasculitis in children less than 5 years old. Numerous diseases, especially those related to the immune system, have established links with the intestinal flora.

Exploring the fate of 6PPD in zebrafish (Danio rerio): Understanding toxicokinetics, biotransformation mechanisms, and metabolomic profiling at environmentally relevant levels.

In recent years, N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) has attracted significant attention in environmental science, yet its behavior in biological systems remains poorly understood. This study involved a 28-day zebrafish exposure experiment at three concentrations (2, 20, and 200 μg/L), to investigate its physiologically based toxicokinetic (PBTK) properties, the formation of biotransformation products, and the metabolic characteristics of liver tissue. The results indicated that the liver and intestines are key organs for 6PPD accumulation, with tissue-specific distribution patterns.

Analysis of Hepatic Lentiviral Vector Transduction: Implications for Preclinical Studies and Clinical Gene Therapy Protocols.

Lentiviral vector-transduced T cells were approved by the FDA as gene therapy anti-cancer medications. Little is known about the effects of host genetic variation on the safety and efficacy of the lentiviral vector gene delivery system. To narrow this knowledge gap, we characterized hepatic gene delivery by lentiviral vectors across the Collaborative Cross (CC) mouse genetic reference population.

A modified approach for treating zygomatic arch fracture with plate fixation: a retrospective study.

Background: Zygomatic complex fractures are prevalent among maxillofacial bone injuries due to the prominence of the zygomatic arch, which can significantly impact facial aesthetics and the ability to open the mouth. Although non-surgical interventions are available for mild cases, severe fractures necessitate surgical intervention. The surgical repair of zygomatic arch fractures poses a risk of injuring the temporal branch of the facial nerve (TBFN).

Advanced imaging in the evaluation of lupus arthritis: A systematic literature review and meta-analysis.

Introduction: Joint involvement is present in up to 95 % of patients with SLE. Arthritis is a main cause of work-related disability and 70-80 % of lupus patients in clinical trials have active joint manifestations.

Objective: To review the evidence on the application of musculoskeletal (MSK) ultrasound (US), magnetic resonance imaging (MRI), and optical imaging (OI) in patients with SLE hand and wrist arthritis, discuss measurement properties of US, MRI, and OI, and to provide combined results from these studies.

CD13 as a potential theranostic target for prostate-specific membrane antigen-negative prostate cancer and first-in-human study of [F]AlF-CD13-L1 PET/CT imaging.

Purpose: Approximately 10% of prostate cancer (PCa) are prostate-specific membrane antigen (PSMA)-negative, leading to blind spots in PSMA-based diagnosis. This study aimed to identify a potential target for PSMA-negative PCa and preliminarily evaluate the feasibility of using radionuclide probe targeting the identified target for PCa diagnosis.

Methods: Quantitative protein analysis was performed on eight PSMA-negative PCa and eleven controls to identify a potential molecular target, followed by validation with an expanded cohort using immunohistochemistry.

Exploring the capabilities of GenAI for oral cancer consultations in remote consultations : Author.

Background: Generative artificial intelligence (GenAI) has demonstrated potential in remote consultations, yet its capacity to comprehend oral cancer has not yet been fully evaluated. The objective of this study was to evaluate the accuracy, reliability and validity of GenAI in addressing questions related to remote consultations for oral cancer.

Methods: A search was conducted on telemedicine platforms in China, summarizing patients' inquiries regarding oral cancer.

Therapeutic potency and possible mechanism of Wuhu decoction underlying asthmatic progression via Th1/Th2 imbalance.

Background: Cough variant asthma (CVA) is a disease with no definitive diagnosis or pathogenic causes, and still lacks effective and safe treatment. Wuhu decoction is a traditional Chinese medicine with potential effects against CVA, of which underlying mechanism remains elusive. The aim of this study is to explore the therapeutic potential of Wuhu decoction against CVA.

Axin formation inhibitor 1 aggravates hepatic ischemia‒reperfusion injury by promoting the ubiquitination and degradation of PPARβ.

Hepatic ischemia‒reperfusion injury (HIRI) is a common pathological phenomenon after hepatectomy and liver transplantation. Here, we aim to explore the role of Axin formation inhibitor 1 (Axin1) in HIRI. In this work, we find that the expression of Axin1 is upregulated after HIRI.

Plant-based meat: The influence on texture by protein-polysaccharide interactions and processing techniques.

As interest in sustainable food production grows, significant strides have been made in developing plant-based meat products. However, this field is still in its early stages and faces several challenges, with replicating the texture of animal meat being the most critical hurdle. Therefore, this review provides a comprehensive overview of the key proteins and polysaccharides commonly used in plant-based meat formulations.

Regional distribution of microvasculature within the canine femoral head: a study of plastinated tissue histology and 3D reconstruction.

Background: Understanding the intraosseous vascularity of the femoral head is important for preserving its structural integrity and function. Disruptions in microcirculation can lead to osteonecrosis of the femoral head (ONFH). This anatomical study aimed to quantify the regional distribution of the microvessels within the trabecular bone of the femoral head.

3D Deep Learning for Virtual Orbital Defect Reconstruction: A Precise and Automated Approach.

Accurate virtual orbital reconstruction is crucial for preoperative planning. Traditional methods, such as the mirroring technique, are unsuitable for orbital defects involving both sides of the midline and are time-consuming and labor-intensive. This study introduces a modified 3D U-Net+++ architecture for orbital defects reconstruction, aiming to enhance precision and automation.

Characterizing metabolomic and proteomic changes in depression: a systematic analysis.

Despite the widespread use of metabolomics and proteomics to explore the molecular landscape of depression, there is a lack of consensus regarding dysregulated molecules with replicable evidence. Thus, this study aimed to identify robust metabolomic and proteomic features in depression by integrating evidence from large-scale studies. In this study, a knowledge base-mining approach was adopted to compile a list of dysregulated molecules derived from metabolomic and proteomic studies.

Correlations between primary tumour location, biomarkers of inflammation and lung injury, and postoperative pulmonary complications in patients underwent laparoscopic colorectomy: a propensity score matched analysis of 300 patients.

Introduction: The impact of distinct primary colorectal cancer (CRC) sites on lung injury and complications remains largely unexplored, despite the palpable differences in surgical positions, procedures, and the resulting mechanically induced respiratory pressures at each site.

Materials And Methods: This study employed a forwards-looking approach utilising the propensity score matching (PSM) method; 300 patients with pathological CRC after laparoscopic surgery from April 2019 to May 2023 were enrolled. Two categories were bifurcated based on their surgical locations: the rectosigmoid colon (RSC) group and the descending/ascending colon (DAC) group, with a 2:1 ratio.