Publications by authors named "Wei Qing Qiu"
Gastric cancer (GC) is one of the most leading malignancies. Long noncoding RNA is related to GC. In this study, 11 miRNAs in the exosomes and six lncRNAs in the tissues was examined by qRT-PCR.
View Article and Find Full Text PDFA new series of C-3'-N-sulfonyl paclitaxel analogs were designed and synthesized from 1-deoxybaccatin VI and their structures were confirmed by H NMR, C NMR and high resolution MS. The synthesized compounds were evaluated for their anti-Hepatocellular carcinoma (HCC) activity against human hepatoma (HepG2) cell line. Bioassay results showed that compounds , and exhibited more potent inhibitory activity against HepG2 cell line in comparison with paclitaxel.
View Article and Find Full Text PDFThree novel nor-seco-taxoids 13, 15, 23 in which the A rings are cleaved but the B, C, and D rings are retained were prepared from 1-deoxybaccatin VI via its nor-dioxo derivative and their structures were confirmed by H NMR, C NMR and high resolution MS. Oxidative introduction of C-1 hydroxyl to 1-deoxybaccatin VI with oxidising agent KBrO and catalyst RuCl led to the dioxo derivative 6 and its structure is determined by X-ray crystallographic analysis. A-seco taxoids 13, 15, 23 with a C-13 ester linkage were tested for cytotoxic activity and all compounds showed no measurable cytotoxic activity against HCT-116 cell line.
View Article and Find Full Text PDFBackground And Objective: Several studies assessed the efficacy of traditional Chinese medical exercise in the management of Parkinson's disease (PD), but its role remained controversial. Therefore, the purpose of this systematic review is to evaluate the evidence on the effect of traditional Chinese medical exercise for PD.
Methods: Seven English and Chinese electronic databases, up to October 2014, were searched to identify relevant studies.
Background: Gastrointestinal stromal tumor (GIST) is known for its wide variability in biological behaviors and it is difficult to predict its malignant potential. The aim of this study is to explore the characteristics and prognostic factors of GIST.
Methods: Clinical and pathological data of 497 GIST patients in our center between 1997 and 2012 were reviewed.
Objective: To evaluate the feasibility and safety of laparoscopic and endoscopic cooperative surgery (LECS) for the treatment of gastric gastrointestinal stromal tumors (GISTs).
Methods: We retrospectively reviewed the data of 69 consecutive patients who underwent LECS, including laparoscopy-assisted endoscopic resection (LAER) and endoscopy-assisted laparoscopic wedge resection (EAWR), for pathologically confirmed gastric GISTs of less than 5 cm in diameter from January 2006 to October 2012.
Results: The tumor was located at the upper third of the stomach in 22 patients, the middle third in 38 and the lower third in nine, with a mean tumor size of 2.
Objective: To explore the clinicopathologic features, treatment and prognosis of gastrointestinal stromal tumor (GIST) complicated with synchronous other alimentary malignant tumors.
Methods: Clinical data of 525 patients with GIST undergoing surgical treatment from August 2004 to November 2012 in Shanghai Renji Hospital were reviewed retrospectively, among whom 46 patients presented synchronous other alimentary malignancy.
Results: GIST and other alimentary malignancy coexisting cases were less likely to be screened out preoperatively (2.
Article Synopsis
- * The procedures were successful with no complications, averaging an operative time of about 85 minutes and a post-operative hospital stay of approximately 5 days.
- * Follow-up indicated that the surgeries were effective, with no recurrences or metastasis observed over a median follow-up period of 12.6 months, highlighting minimal invasiveness and quick recovery.