[Comprehensive Assessment of the Health Risk of Cadmium Exposure from Soil-wheat System in Wheat Fields in Northern China].

Accurately assessing the health risks of cadmium （Cd） exposure in the soil-wheat system is of great importance for the formulation of regional health risk prevention measures. Based on regional large-scale survey and Monte Carlo simulation methods, a case study on the health risk of Cd exposure in a soil-wheat system in a wheat production area of North China Plain was conducted by constructing a comprehensive health risk assessment （CHRA） model. The results showed that 73% of the soil samples in the study area exceeded the screening value of Cd for farmland soil （GB 15618-2018） and 57.

Manduca sexta caterpillars parasitized by the wasp Cotesia congregata stop chewing despite an intact motor system.

The parasitic wasp Cotesia congregata suppresses feeding in its host, the caterpillar Manduca sexta, during specific periods of wasp development. We examined both feeding behaviour and the neurophysiology of the mandibular closer muscle in parasitized and unparasitized control M. sexta to determine how the wasp may accomplish this.

Discovery of extracellular vesicle-delivered miR-185-5p in the plasma of patients as an indicator for advanced adenoma and colorectal cancer.

Background: We aimed to evaluate whether extracellular vesicles (EV)-derived microRNAs (miRNAs) can be used as biomarkers for advanced adenoma (AA) and colorectal cancer (CRC).

Methods: We detected the changes in the plasma EV-delivered miRNA profiles in healthy donor (HD), AA patient, and I-II stage CRC patient groups using miRNA deep sequencing assay. We performed the TaqMan miRNA assay using 173 plasma samples (two independent cohorts) from HDs, AA patients, and CRC patients to identify the candidate miRNA(s).

[Prediction of Cadmium Uptake Factor in Wheat Based on Machine Learning].

Applying machine learning methods to resolve the cadmium (Cd) uptake characteristics of regional soil-wheat systems can contribute to the accuracy and rationality of risk decisions. Based on a regional survey, we constructed a Freundlich-type transfer equation, random forest (RF) model, and neural network (BPNN) model to predict wheat Cd enrichment factor (BCF-Cd); verified the prediction accuracy; and assessed the uncertainty of different models. The results showed that both RF (=0.

Investigation of Neurological Complications after COVID-19 Vaccination: Report of the Clinical Scenarios and Review of the Literature.

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), broke out in 2019 and became a pandemic in 2020. Since then, vaccines have been approved to prevent severe illness. However, vaccines are associated with the risk of neurological complications ranging from mild to severe.

[Characteristics and influencing factors of microbial function in soils around a typical mining smelter].

Soil microorganisms were sensitive to heavy metal pollution, whose ecological effect on soil microbial community was impacted by the interaction of contaminated stresses and environmental factors. To explore the dominant factors governing those effects in heavy metal contaminated soil, field investigation was conducted for soil from different land use types in an area surrounding a typical mining smelter in Hunan Province. Soil microbial function parameters including microbial biomass carbon (MBC), basal respiration (BR), substrate-induced respiration (SIR) and nitrification potential (PNR) were used as measure endpoints for ecological effect to reflect soil carbon and nitrogen cycling.

[Assessing the Lead Accumulation Risks of Wheat Grain by Developing a Source-Specific Accumulation Risk Assessment Model].

Characterizing the lead (Pb) transfer in the "source-soil-wheat" chain is of great importance for the prevention and control of the Pb accumulation risk in wheat grain harvested from the croplands of China. In this study, we used the Jiyuan City, northern China, as a case study to investigate the influence of contamination sources and soil factors on the accumulation of Pb in wheat grain. A site-specific source risk assessment model (SRAM), coupling the positive matrix factorization model, Freundlich-type function, and the Monte Carlo simulation method, was developed to estimate the risk of Pb accumulation in wheat grain harvested from different scenarios.

Salt-Inducible Kinase 1 is a potential therapeutic target in Desmoplastic Small Round Cell Tumor.

Desmoplastic Small Round Cell Tumor (DSRCT) is a rare and aggressive malignant cancer caused by a chromosomal translocation t(11;22)(p13;q12) that produces an oncogenic transcription factor, EWSR1-WT1. EWSR1-WT1 is essential for the initiation and progression of DSRCT. However, the precise mechanism by which EWSR1-WT1 drives DSRCT oncogenesis remains unresolved.

[Security Risk and Influencing Factors of Agro-Products in Farmland Soil Around a Typical Mining Smelter].

The security risks of heavy metal pollution in agro-products are becoming increasingly serious. This paper investigated the heavy metal contamination of farmland soils and agro-products around a typical mining smelter in Hunan province, and explored the influencing factors based on principal component and correlation analyses. The results showed that the soils were significantly contaminated by heavy metals, with a mean concentrations of Cd, Cu, Pb, and Zn of 9.

Source tracing of potentially toxic elements in soils around a typical coking plant in an industrial area in northern China.

Coking plants are a substantial source of potentially toxic elements (PTEs) in soil. In this study, we examined the concentration of PTEs, the soil physicochemical properties, and the Pb isotopes in the soil inside and around a coking plant in an industrial city in northern China. We analyzed the spatial distribution of PTEs and the pollution risk areas by I index, the enrichment factor (EF), and the Nemerow index, and we quantitatively identified the contribution of PTE pollution sources in the soil on a small- and medium-scale (plant and work section).

Preventive Healthcare and Management for Acute Lymphoblastic Leukaemia in Adults: Case Report and Literature Review.

Acute lymphoblastic leukaemia (ALL) is diagnosed by the presence of at least 20% lymphoblasts in the bone marrow. ALL may be aggressive and include the lymph nodes, liver, spleen, central nervous system (CNS), and other organs. Without early recognition and timely treatment, ALL will progress quickly and may have poor prognosis in clinical scenarios.

LncRNA TUG1 Demethylated by TET2 Promotes NLRP3 Expression, Contributes to Cerebral Ischemia/Reperfusion Inflammatory Injury.

LncRNA TUG1 has not yet been reported in cerebral ischemia/reperfusion (I/R) injury. Methylcytosine dioxygenase TET2 is involved in ischemic damage. This study aimed to investigate the effects of TUG1 demethylated by TET2 on I/R-induced inflammatory response and identified its possible mechanisms.

[Simulation Cadmium (Cd) Accumulation in Typical Paddy Soils in South China].

The simulation analysis of the migration path and soil accumulation trend of Cd in paddy soil systems could contribute to improved scientific and reasonable risk decision-making. In this study, based on a regional survey of environmental media in Youxian County, Hunan Province, a pollutant accumulation model (PAM) was built to predict the cumulative trend of Cd in paddy soils. Combined with Monte Carlo simulation, the PAM model was used to evaluate the effectiveness and sustainability of various remediation measures.

Inhibitor Kappa B Kinase β, Modulated by DJ-1/p-VHL, Reduces Phosphorylated Tau (p-Tau) Accumulation via Autophagy in Alzheimer's Disease Model.

It has been demonstrated Inhibitor Kappa B Kinase β (IKKβ) facilitates autophagy, which in turn mediates p-Tau protein clearance. However, the specific regulatory mechanism in Alzheimer's disease (AD) remains unclear. Firstly, AD model was generated by the intracerebroventricular (ICV) injection of the Β-amyloid 1-42 (Aβ) peptide.

Restoration of cartilage defects using a superparamagnetic iron oxide-labeled adipose-derived mesenchymal stem cell and TGF-β3-loaded bilayer PLGA construct.

We aimed to evaluate the capacity of the bilayer polylactic-co-glycolic acid (PLGA)/TGF-β3/adipose-derived mesenchymal stem cell (ADSC) construct used to repair cartilage defects and the role of ADSCs in the repair process . Defects were created surgically on the femoropatellar groove of knee joints in 64 rabbits. All the rabbits were randomly divided into four groups: defect group, PLGA group, PLGA/TGF-β3 group and PLGA/TGF-β3/ADSC group.

[Construction and Application of an Evaluation System for Soil Environmental Carrying Capacity].

To understand the effect of soil environmental carrying capacity on pollutants and human activities, as well as to effectively prevent the aggravation of soil pollution and control soil environmental risks, a comprehensive indicator system for soil environmental carrying capacity is developed by analyzing the input-output flux and risk characteristics of soil pollutants. Furthermore, an evaluation method for soil environmental carrying capacity is proposed by defining safety coefficients related to evaluation indicators. Based on evaluation of soil environmental quality, the system reflects soil properties, pollution evolution trends, and risk characteristics, focusing on the soil buffering function.

[Construction and Application of Early Warning System for Soil Environmental Quality].

Early warning of soil environmental quality is an important basis for implementing classified and graded soil risk management measures. To quickly understand the regional soil environmental quality and take effective measures in time to prevent continuous soil pollution before deterioration of soil environmental quality, a simple, effective, and quantifiable early warning system for soil environmental quality of agricultural land and development land was respectively established based on environmental capacity and pollutant input-output flux theory. Furthermore, corresponding method and mechanism for early warning were defined based on soil environmental quality standards, food safety standards, and carcinogenic risk coefficients.

[Spatial-temporal Variation and Source Change of Heavy Metals in the Cropland Soil in the Industrial City].

Environmental policy regulation affects the accumulation of heavy metals in soil. Two soil surveys were conducted in farmland in industrial cities. Classical statistical and geostatistical methods were applied to examine the content changes and spatial-temporal distribution characteristics of Cd, Pb, Cu, and Zn in soil.

EGb761 ameliorates cell necroptosis by attenuating RIP1-mediated mitochondrial dysfunction and ROS production in both in vivo and in vitro models of Alzheimer's disease.

Objectives: To investigate the neuroprotective effect of Gingko biloba extract 761 (EGb761) in Alzheimer's disease (AD) models both in vivo and in vitro and the underlying molecular mechanism.

Methods: Cultured BV2 microglial cells were treated with Aβ to establish an in vitro AD model. The in vivo rat AD model was established by injecting Aβ.

Immediate knowledge improvement and long-term teaching confidence after general medicine faculty training program.

Background/purpose: This study analyzed the effects of the General Medicine Faculty Training Program (GMFTP), which was implemented in 2009. The training program includes a 7-hour basic training (BT) to introduce ways of teaching and assessing the 6 core competencies identified by the Accreditation Council for Graduate Medical Education, and a 40-hour clinical training program.

Methods: Physicians from different hospitals attended the GMFTPs.

Knockdown of KIAA1199 suppresses IL-1β-induced cartilage degradation and inflammatory responses in human chondrocytes through the Wnt/β-catenin signalling pathway.

The overproduction of proteolytic enzymes and dysregulation of extracellular matrix (ECM) metabolism have been shown to accelerate the degradation process of articular cartilage. The purpose of this study was to investigate the role of KIAA1199 and its association with the pathophysiology of osteoarthritis (OA). We found that the expression of KIAA1199 was significantly upregulated in OA cartilage compared with normal tissues.