Metabolic regulation of amino acids provides an important basis for individualized nutritional therapy for patients with gastric cancer during the perioperative period.

Background: Gastric cancer is a prevalent malignancy worldwide, with early detection and treatment being vital to improving patient outcomes. Amino acids (AAs), as essential regulators in cancer cell metabolism, are implicated in the progression and response to treatment.

Methods: This study aimed to investigate the dynamics of plasma AA levels in gastric cancer patients preoperatively, postoperatively, and following nutritional intervention, comparing them to healthy controls.

Synergistic effect of the Phytic acid-halamine as a novel durability, antibacterial and flame retardant system for cotton fibers.

Phytic acid's high-efficiency flame retardant and N-halamine antibacterial were synergistically applied to cotton fibers for durable antibacterial and flame retardancy. Antimicrobial flame retardant structures were characterized by H Nuclear Magnetic Resonance Spectra (NMR) and Fourier Transform Infrared Spectrometer (FT-IR). FT-IR, X-ray Photoelectron Spectroscopy (XPS), Scanning Electron Microscope (SEM), Thermogravimetric (TG), Vertical Flammability Test (VFT), and Limiting Oxygen Index (LOI) were utilized to test and characterize the prepared cotton fibers.

Advances in sulodexide-based long-term anticoagulation for a myasthenia gravis patient with giant thymoma.

This case report describes a geriatric male patient with myasthenia gravis (MG) secondary to giant thymoma, presenting with progressive muscle weakness and ptosis. The diagnosis of MG was confirmed through pathology, imaging, and laboratory evaluations. Considering the significant surgical risks associated with the giant thymoma, adjuvant chemotherapy was initiated.

Primary gingival diffuse large B‑cell lymphoma with muscle invasion: A case report.

Primary gingival diffuse large B-cell lymphoma (DLBCL) with muscle invasion is rare and accounts for ~0.5% of all reported cases of extranodal lymphoma. The present study describes the case of a 49-year-old man that initially presented at Yingshan County People's Hospital (Nanchong, China) in August 2017 with a chief complaint of tenderness and swelling of the jaw.

Enhanced visible-light-driven photocatalytic degradation of tetracycline wastewater using surfactant-modified Au-loaded CeO nanorods.

The residues of tetracyclines (TCs) antibiotics present significant challenges in terms of contamination and pose a threat to human health. In this study, a cost-effective n-type semiconductor, CeO, were loaded with small amounts of Au nanoparticles were fabricated by one-step hydrothermal method under alkaline conditions in the presence of the surfactant CTAB. Characterization tests revealed that Au/CeO had significant visible light absorption capacity and good e/h separation efficiency.

ECHS1 as a Lipid Metabolism Biomarker for Pediatric Focal Segmental Glomerulosclerosis.

Focal segmental glomerulosclerosis (FSGS) is a common cause of nephrotic syndrome and often leads to end-stage renal disease. However, the underlying pathophysiological mechanisms that contribute to disease progression require further investigation to establish appropriate therapeutic targets and biomarkers. This study aimed to clarify the molecular mechanisms underlying FSGS by focusing on differentially expressed genes (DEGs) and lipid metabolism-related genes (LMRGs).

The role of glutathione for oxidative stress and pathogenicity of .

is an important zoonotic pathogen that threatens human and pig health. During infection, the host can impose oxidative stress to resist pathogen invasion. Resistance to oxidative toxicity is an important factor for pathogens.

Emission and risk of atmospheric hexachlorobutadiene might be underestimated globally.

Ambiguous emission of new pollutants is a fundamental obstacle of risk prevention, such as hexachlorobutadiene (HCBD). To quantify the HCBD emission in China, we probed the emission factors for main sources based on analysis of 847 gas samples from field experiments. Considering treatment efficiency, emissions of 362 kinds of sources were measured.

Targeting AMPK related signaling pathways: A feasible approach for natural herbal medicines to intervene non-alcoholic fatty liver disease.

Non-alcoholic fatty liver disease (NAFLD) is a metabolic disease characterized by abnormal deposition of lipid in hepatocytes. If not intervened in time, NAFLD may develop into liver fibrosis or liver cancer, and ultimately threatening life. NAFLD has complicated etiology and pathogenesis, and there are no effective therapeutic means and specific drugs.

The Large Language Models on Biomedical Data Analysis: A Survey.

With the rapid development of Large Language Model (LLM) technology, it has become an indispensable force in biomedical data analysis research. However, biomedical researchers currently have limited knowledge about LLM. Therefore, there is an urgent need for a summary of LLM applications in biomedical data analysis.

A comparative study of statistical methods for identifying differentially expressed genes in spatial transcriptomics.

Spatial transcriptomics (ST) provides unprecedented insights into gene expression patterns while retaining spatial context, making it a valuable tool for understanding complex tissue architectures, such as those found in cancers. Seurat, by far the most popular tool for analyzing ST data, uses the Wilcoxon rank-sum test by default for differential expression analysis. However, as a nonparametric method that disregards spatial correlations, the Wilcoxon test can lead to inflated false positive rates and misleading findings.

Effects of simultaneous multislice acceleration on the stability of radiomics features in parametric maps of IVIM and DKI in uterine cervical cancer.

Purpose: The aim of this study was to investigate the influence of the simultaneous multislice acceleration (SMS) technique as well as two-dimensional (2D) and three-dimensional (3D) tumor segmentations on radiomics features (RFs) within the parametric maps of cervical cancer, which were computed by intravoxel incoherent motion (IVIM) and diffusion kurtosis imaging (DKI). Additionally, the study sought to identify those RFs that could characterize the clinical stages (low-stage vs. high-stage) of cervical cancer.

Assessing the environmental risks of sulfonylurea pollutants: Insights into the risk priority and structure-toxicity relationships.

Sulfonylureas are widely used herbicides globally; however, the health risks associated with exposure to these compounds are poorly understood. This study used fuzzy clustering to categorize 44 sulfonylurea compounds into three risk priority levels (I, II, and III) and further investigated their structure-toxicity relationships. The order of the risk priority levels was level I＜level II＜level III.

Resonant Frequency Tracking of a Cantilever-Enhanced Fiber-Optic Photoacoustic Gas Sensor Based on Solid Absorption.

The cantilever-enhanced fiber-optic photoacoustic (PA) sensor (FOPAS) has the advantages of intrinsic safety, small size, and high sensitivity. However, the resonance frequency of the FOPAS is easily affected by temperature, which leads to gas concentration measurement errors. Herein, the cantilever-enhanced FOPAS with resonance frequency tracking is presented to improve the stability of gas detection.

Multi-modal Wearable Patch for Localized Monitoring of Post-operative Skin Flap Transplantation.

Monitoring the status of skin flap transplantation (SFT) is crucial for early intervention, particularly to mitigate risks, such as necrosis and complications arising from poor vascularization or infection. Current clinical practices for monitoring SFT rely on intermittent gauze removal, risking secondary injury and delayed complication detection. While wearable sensors have been proposed, existing systems lack simultaneous and multi-parameter monitoring, poor wearability, and the ability to localize complications within the flap.

Current Status and Future Directions of Ferroptosis Research in Breast Cancer: Bibliometric Analysis.

Background: Ferroptosis, as a novel modality of cell death, holds significant potential in elucidating the pathogenesis and advancing therapeutic strategies for breast cancer.

Objective: This study aims to comprehensively analyze current ferroptosis research and future trends, guiding breast cancer research advancements and innovative treatment strategies.

Methods: This research used the R package Bibliometrix (Department of Economic and Statistical Sciences at the University of Naples Federico II), VOSviewer (Centre for Science and Technology Studies at Leiden University), and CiteSpace (Drexel University's College of Information Science and Technology), to conduct a bibliometric analysis of 387 papers on breast cancer and ferroptosis from the Web of Science Core Collection.

Characterization of PRDM9 Multifunctionality in Yak Testes Through Protein Interaction Mapping.

Meiotic recombination is initiated by the formation of programmed DNA double-strand breaks during spermatogenesis. PRDM9 determines the localization of recombination hotspots by interacting with several protein complexes in mammals. The function of PRDM9 is not well understood during spermatogenesis in mice or yaks.

Cuticle thickening mediates insecticide penetration resistance in Spodoptera litura.

Introduction: Long-term and extensive use of chemical pesticides has led to the development of resistance in many important agricultural pests. The mechanisms of resistance formation in pests are complex and variable, and unraveling the resistance mechanisms is the key to control resistant pests. Insect cuticle, as the first line of defense for insecticides, plays a non-negligible role in insecticide penetration resistance.

Design and validation of an alignment free adaptive joint torque measurement system.

Purpose: This study introduces a transferable alignment-free adaptive joint torque measurement (AFAJTM) system designed to resolve inconsistencies in torque measurements caused by misalignment between dynamometer and joint rotational axes, improving accuracy and reliability in joint torque assessment.

Method: This study presents the design and control methodology of an alignment free adaptive joint torque measurement system. An elbow joint torque measurement device (EJTMD) was developed, and its torque consistency and repeatability were evaluated at various misalignment positions using a joint simulation model.

The influence of different stress loading on the biomechanics of motion segments in isolated rabbit spines.

Intervertebral disc degeneration greatly affects daily life. Suitable mechanical stress is important for intervertebral disc health as it affects disc cells. Research shows it helps disc cell proliferation and collagen synthesis.

Irf7 aggravates prostatitis by promoting Hif-1α-mediated glycolysis to facilitate M1 polarization.

Background: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common disorder associated with voiding symptoms and pain in the pelvic or perineal area. Macrophages, particularly the pro-inflammatory M1 subtype, are crucial initiating of CP/CPPS. Interferon regulatory factor 7 (Irf7) has been implicated in promoting M1 polarization, contributing to the onset and progression of autoimmunity.

T2-weighted imaging of rectal cancer using a 3D fast spin echo sequence with and without deep learning reconstruction: A reader study.

Purpose: To compare image quality and clinical utility of a T2-weighted (T2W) 3-dimensional (3D) fast spin echo (FSE) sequence using deep learning reconstruction (DLR) versus conventional reconstruction for rectal magnetic resonance imaging (MRI).

Methods: The study included 50 patients with rectal cancer who underwent rectal MRI consecutively between July 7, 2020 and January 20, 2021 using a T2W 3D FSE sequence with DLR and conventional reconstruction. Three radiologists reviewed the two sets of images, scoring overall SNR, motion artifacts, and overall image quality on a 3-point scale and indicating clinical preference for DLR or conventional reconstruction based on those three criteria as well as image characterization of bowel wall layer definition, tumor invasion of muscularis propria, residual disease, fibrosis, nodal margin, and extramural venous invasion.