Chromosome-level genome assembly and annotation of largemouth bronze gudgeon (Coreius guichenoti).

Coreius guichenoti, mainly distributed in upstream regions of the Yangtze River China, is currently on the brink of extinction and listed as national secondary protected animal. In this study, we aimed to obtain the chromosome-level genome of C. guichenoti using PacBio and Hi-C techniques.

Fluctuation asymmetry of otoliths from Coilia brachygnathus in Changhu Lake: A first study in inland waters of China.

Fluctuating Asymmetry (FA) in fish otoliths is an indicator of arbitrarily tiny variations between bilateral otolith characters, and it serves as an effective indicator of growth and developmental differences due to environmental conditions. Due to their unique resident traits, the Coilia brachygnathus can provide a potential insight to the environmental pressure reflected by its otolith FA. In this study, 228 C.

Effect of Different Opening Diet on the Growth, the Structure of the Digestive Tract and Digestive Enzyme Activity of Larval and Juvenile .

One of the crucial factors influencing the growth and viability of larvae and juveniles is their opening diets. The objective of this study was to identify suitable initial feed options for larvae and juveniles. A total of 1200 newly hatched with an average weight of 18.

Vertical distribution of microplastics in the Western Pacific Warm Pool: In situ results comparison of different sampling method.

Marine microplastics (MPs) are recognized as a growing severe environmental concern. The vertical distribution pattern of MPs in the ocean is still elusive. Meanwhile, different sampling methods have been deployed in previous studies, resulting in difficulties in compiling data.

The biological functions of microcystins.

Microcystins are potent hepatotoxins predominantly produced by bloom-forming freshwater cyanobacteria (e.g., Microcystis, Planktothrix, Dolichospermum).

Clinicopathological significance of cancer stem cell marker CD44/SOX2 in esophageal squamous cell carcinoma (ESCC) patients and construction of a nomogram to predict overall survival.

Background: Esophageal squamous cell carcinoma (ESCC), a prevalent malignancy within the upper gastrointestinal system, is characterized by its unfavorable prognosis and the absence of specific indicators for outcome prediction and high-risk case identification. In our research, we examined the expression levels of cancer stem cells (CSCs), markers CD44/SOX2 in ESCC, scrutinized their association with clinicopathological parameters, and developed a predictive nomogram model. This model, which incorporates CD44/SOX2, aims to forecast the overall survival (OS) of patients afflicted with ESCC.

Changes in CO concentration drive a succession of toxic and non-toxic strains of Microcystis blooms.

The dynamic changes between toxic and non-toxic strains of Microcystis blooms have always been a hot topic. Previous studies have found that low CO favors toxic strains, but how changing dissolved CO (CO [aq]) in water body influences the succession of toxic and non-toxic strains in Microcystis blooms remains uncertain. Here, we combined laboratory competition experiments, field observations, and a machine learning model to reveal the links between CO changes and the succession.

Neuroprotective effect of 1,25‑dihydroxyvitamin D3 against hyperoxia‑induced brain injury in premature rats.

Studies have shown that vitamin D plays a crucial role in brain development, brain metabolism and neuroprotection. There is little evidence for the neuroprotective effect of 1, 25‑dihydroxyvitamin D3 (1,25‑(OH)2D3) on various brain injury models. The aim of this study was to investigate the neuroprotection effect of 1,25‑(OH)2D3 against hyperoxia‑induced brain injury in premature rats.

Changes in nitrogen metabolism of phosphorus-starved bloom-forming cyanobacterium Microcystis aeruginosa: Implications for nutrient management.

The surplus of nitrogen plays a key role in the maintenance of cyanobacterial bloom when phosphorus has already been limited. However, the interplay between high nitrogen and low phosphorus conditions is not fully understood. Nitrogen metabolism is critical for the metabolism of cyanobacteria.

Dynamic signatures of microplastic distribution across the water column of Yangtze River Estuary: Complicated implication of tidal effects.

Riverine microplastic (MP) discharge into the ocean contributes greatly to global MP contamination, yet our understanding of this process remains primitive. To deepen our interpretation of the dynamic MP variation throughout the estuarine water columns, we sampled at Xuliujing, the saltwater intrusion node of the Yangtze River Estuary, over the course of ebb and flood tides in four seasons (July and October 2017, January and May 2018 respectively). We observed that the collision of downstream and upstream currents contributed to the high MP concentration and that the mean MP abundance fluctuated with the tide.

Phosphorylation of AKT by lysyl oxidase-like 2 activates the PI3K/AKT signaling pathway to promote proliferation, invasion and metastasis in esophageal squamous carcinoma.

Objective: Esophageal squamous cell carcinoma (ESCC) is a common and aggressive malignancy of the gastrointestinal tract for which therapeutic options are scarce. This study screens for LOXL2, a key gene in ESCC, and explains the molecular mechanism by which it promotes the progression of ESCC.

Methods: Immunohistochemical staining was performed to detect the expression level of LOXL2 in ESCC tissues and paraneoplastic tissues.

Copper and Zinc Treatments Alter the Thyroid Endocrine System in Zebrafish Embryos/Larvae.

Copper (Cu) and zinc (Zn) are two kinds of heavy metals essential to living organisms. Cu and Zn at excessive concentrations can cause adverse effects on animals, but little is known about the thyroid-disrupting effects of these metals in fish, especially in the early developmental transition stage from embryos to larvae. Wild-type zebrafish embryos were used to expose to Cu (0, 1.

Variations of trophic structure and niche space in fish community along a highly regulated subtropical large river.

The trophic interactions between consumers and resources play a vital role in the stability of communities. In river systems, fragmentation of natural habitats and environmental changes alters the energy basis and community composition, consequently leading to variations in the community's trophic structure and niche space. However, our understanding of how the trophic structure responds to environmental changes is still very limited.

Sex-specific thyroid disruption caused by phenanthrene in adult zebrafish (Danio rerio).

Polycyclic aromatic hydrocarbons (PAHs) are well-known contaminants with widespread distribution in environment and food. Phenanthrene is one of the most abundant PAHs in food and aquatic environment and generates reproductive and developmental toxicity in zebrafish. Nonetheless, whether phenanthrene caused sex-specific thyroid disruption in adult zebrafish is unclear.

Application of Doctor-Nurse-Patient Co-Decision-Making Nursing Intervention Based on Evidence-Based Problems in the Rehabilitation of Acute Ankle Lateral Collateral Ligament Injury.

Objective: The aim of this study is to study the application effects of doctor-nurse-patient co-decision-making nursing intervention based on evidence-based problems in the rehabilitation of acute ankle lateral collateral ligament injury.

Methods: 150 patients with acute ankle lateral collateral ligament injury who were treated in the hospital between December 2020 and December 2021 were selected, and they were divided into the routine group and the evidence-based group by the random number table method, with 75 cases in each group. The patients in the routine group received routine nursing intervention, while the patients in the evidence-based group adopted doctor-nurse-patient co-decision-making nursing intervention based on evidence-based problems, and both groups were intervened for 1 month.

Exponential decrease of airborne microplastics: From megacity to open ocean.

Atmospheric transport has been recognized as an important route for microplastics (MPs) entering the ocean since the early 2019s, yet little data of their distribution patterns in marine air are currently available. In this study, we conducted continuous measurements of atmospheric MPs in the marine boundary layer across the western Pacific Ocean. Results suggested that synthetic MPs comprised 25.

Research Progress on the Effect of Epilepsy and Antiseizure Medications on PCOS Through HPO Axis.

Epilepsy is a common chronic neurological disease that manifests as recurrent seizures. The incidence and prevalence of epilepsy in women are slightly lower than those in men. Polycystic ovary syndrome (PCOS), a reproductive endocrine system disease, is a complication that women with epilepsy are susceptible to, and its total prevalence is 8%-13% in the female population and sometimes as high as 26% in female epilepsy patients.

Ecological risk assessment of marine microplastics using the analytic hierarchy process: A case study in the Yangtze River Estuary and adjacent marine areas.

Microplastic (MP) pollution is ubiquitous in the terrestrial and marine environments, even in the air. However, ecological risk assessment studies of microplastics are scarce. In the present study, an ecological risk assessment model was built to evaluate the risks of microplastics in the Yangtze River Estuary and adjacent marine areas.

Comprehensive methylation profile of CSF cfDNA revealed pathogenesis and diagnostic markers for early-onset Parkinson's disease.

Early-onset Parkinson's disease (EOPD) is one uncommon Parkinson's disease subtype with characteristic clinicopathological features. The full epigenomic profile of EOPD is largely unknown. We performed the first study to investigate the EOPD full methylation profile of cerebrospinal fluid (CSF) cell-free DNA (cfDNA) from 26 EOPD patients and 10 control patients.

Enhanced impacts evaluation of Typhoon Sinlaku (2020) on atmospheric microplastics in South China Sea during the East Asian Summer Monsoon.

Atmospheric transport is an important pathway through which microplastics (MPs) are widely exchanged between marine and terrestrial environments. However, the impacts of frequent extreme weather events, such as typhoons, on atmospheric MPs is poorly understood. To address this issue, we collected suspended atmospheric MPs (SAMPs) and rainfall samples in the South China Sea during Typhoon Sinlaku (2020).

Changes and significance of serum FGF21 in children with primary nephrotic syndrome and chronic renal failure.

Objective: The aim of the study was to investigate the changes and significance of serum fibroblast growth factor 21 (FGF21) in children with primary nephrotic syndrome (PNS) and chronic renal failure.

Methods: Pediatric patients with active PNS and normal renal function (the nephrotic syndrome group), pediatric patients with chronic renal failure (the renal failure group), and children who had healthy physical examinations (the control group) were included. The serum levels of FGF21, total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL-C), and low-density lipoprotein (LDL-C) were measured by enzyme-linked immunosorbent assay (ELISA), and the serum albumin and 24 h urine protein were measured in the PNS group.

Quantitative Proteomic and Microcystin Production Response of to Phosphorus Depletion.

blooms are the most widely distributed and frequently occurring cyanobacterial blooms in freshwater. Reducing phosphorus is suggested to be effective in mitigating cyanobacterial blooms, while the underlying molecular mechanisms are yet to be elucidated. In the present study, isobaric tags for relative and absolute quantitation (iTRAQ)-based quantitative proteomics was employed to study the effects of phosphorus depletion on FACHB-905.

Diagnostic Value of Structural and Functional Neuroimaging in Autoimmune Epilepsy.

Epilepsy is a common nervous system disease, which affects about 70 million people all over the world. In 2017, the International League Against Epilepsy (ILAE) considered immune factors as its independent cause, and the concept of autoimmune epilepsy (AE) was widely accepted. Early diagnosis and timely treatment can effectively improve the prognosis of the disease.