Publications by authors named "Wei Miao Tan"
Background: Animal models are significant for understanding human osteoarthritis (OA). This study compared the synovial fluid proteomics changes in surgical and chemical induced OA models.
Methods: Thirty rabbits either had anterior cruciate ligament transection (ACLT) procedure or injected intra-articularly with monosodium iodoacetate (MIA, 8 mg) into the right knee.
Article Synopsis
- Osteoarthritis (OA) affects both the bone and cartilage, and this study examines changes in these tissues through surgically (ACLT) and chemically (MIA) induced OA in rabbits using micro-CT and histology.
- Thirty rabbits were split into two groups to analyze the effects on subchondral bones and cartilage over 12 weeks post-induction, with specific attention to bone micro-architecture.
- The results showed contrasting bone remodeling: the surgical group had increased bone volume and thickness, while the chemical group experienced bone loss and more severe cartilage damage, highlighting different progression pathways and potential treatment approaches.
This case study is to report the proteins detected by proteomic analysis of synovial fluid from a dog diagnosed with idiopathic immune-mediated polyarthritis, and to compare it with healthy dogs. Synovial fluid was collected via arthrocentesis from a dog diagnosed with immune-mediated polyarthritis. Protein precipitation was performed on the synovial fluid, followed by isoelectric focusing and 2-dimensional gel electrophoresis.
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