A generic and dynamic measure of health-related quality of life across a variety of health and disease conditions: insights from healthy individuals and patients with a variety of diagnoses.

Objectives: Health-Significant Quality of Life Measure (Health-SigQOLM) provides a generic and dynamic assessment of Health-related quality of life (HRQOL). This study aims to assess the HRQOL among healthy and non-healthy participants with varying chronic diseases.

Results: Comparisons between healthy and non-healthy participants revealed statistically significant differences (p < 0.

Cytokine profile of bronchoalveolar lavage in patients with and without checkpoint inhibitor pneumonitis.

Background: Checkpoint inhibitor pneumonitis (CIP) that develops following immune checkpoint inhibitor (ICI) treatment can be difficult to distinguish from other common etiologies of lung inflammation in cancer patients. Here, we evaluate the bronchoalveolar lavage fluid (BAL) for potential biomarkers specific to CIP.

Methods: We conducted a retrospective study of patients who underwent standard of care bronchoscopy to compare the cytokines of interest between patients with and without CIP and with and without immune-mediated pulmonary diseases.

Design of upper limb muscle strength assessment system based on surface electromyography signals and joint motion.

Purpose: This study aims to develop a assessment system for evaluating shoulder joint muscle strength in patients with varying degrees of upper limb injuries post-stroke, using surface electromyographic (sEMG) signals and joint motion data.

Methods: The assessment system includes modules for acquiring muscle electromyography (EMG) signals and joint motion data. The EMG signals from the anterior, middle, and posterior deltoid muscles were collected, filtered, and denoised to extract time-domain features.

Urbanization weakens vegetation resilience in the Pearl River Delta, China.

Rapid urbanization has introduced increasingly complex social-ecological processes, intensifying the impacts on vegetation growth. Assessing urban vegetation resilience is critical to understanding urban vegetation growth. However, the current understanding of vegetation resilience in highly urbanized areas, especially regarding the influence of human activities, remains limited, constraining efforts toward sustainable urban vegetation management.

Transcatheter tricuspid valve intervention versus medical therapy for symptomatic tricuspid regurgitation: a meta-analysis of reconstructed time-to-event data.

Background: Transcatheter tricuspid valve intervention (TTVI) has demonstrated safety and efficacy in treating high-risk patients with tricuspid regurgitation (TR). The authors aimed to perform a meta-analysis based on reconstructed time-to-event data to compare the clinical benefit of TTVI with medical therapy (MED).

Methods: A systematic literature search was conducted in major databases, including PubMed, Embase, and the Cochrane Library, until 20 October 2023.

Steps to Avoid Falls in the Elderly - a TECHnology Enhanced Intervention (SAFE-TECH) study: randomized controlled trial protocol for a community-based, multi-component fall prevention program.

Background: Falls and fall-related injuries among older adults in Singapore are a serious health problem that require early intervention. In previous research, exercise interventions have been effective in improving functional outcomes and reducing falls for a broad group of older adults. However, results from multi-domain, multi-component falls prevention programs for high fall risk older adults in the community remain equivocal.

Chinese guidelines for minimally invasive donor hepatectomy in living donor liver transplantation (2024 edition).

Background: Minimally invasive surgeries are increasingly central to modern medicine, particularly in liver transplantation. These techniques, which offer reduced trauma, precise operations, minimal bleeding, and swift recovery, are, however, unevenly adopted across China. Only a limited number of centers routinely perform minimally invasive donor hepatectomies, indicating a significant imbalance in the development and application of these advanced procedures.

How Message-Evoked Emotions Undermine Persuasion: The Mediating Role of Fear and Anger in Health Message Effects Among Older Adults.

Guided by literature on framing, this study explored how the presence of age labels in different message frames influenced message-evoked fear and anger responses, particularly for older adults with different levels of need for autonomy (NFA), which ultimately affected their physical activity intentions. The results of a three-factor between-subjects experiment, with message frame (gain versus loss) and age label (present versus absent) as manipulated variables and NFA (low versus medium versus high) as quasi-experiment variable ( = 237) revealed that loss-framed message evoked higher levels of fear and anger as compared to gain-framed message. Furthermore, the anger elicited by loss-framing was more pronounced when age labels were present, especially among older adults with low NFA.

The influence of dialect loss on tone perception: Diminishing voice quality cues in preserved tone contrast.

This study examines whether cue integration in tone perception undergoes changes caused by disparities in language experience among two groups of multidialectal speakers from Changsha: participants in the dialect-preserving group speak Changsha dialect (CD), Changsha Plastic Mandarin (CPM), and Standard Mandarin (SM), whereas participants in the dialect-lost group speak CPM and SM but not CD. An identification test on T1 and T4 was conducted, both of which are present in the CD and CPM. T1 and T4 are associated with a high pitch, but they differ in pitch height, pitch contour, and voice quality.

Production of 2-O-α-d-glucopyranosyl-l-ascorbic acid using sucrose phosphorylase by semi-rational design.

2-O-α-d-glucopyranosyl-l-ascorbic acid (AA-2G) is often substituted for l-ascorbic acid (L-AA) in health- and skincare products due to its enhanced stability and comparable antioxidant. Enzymatic catalysis for AA-2G is gaining widespread interest and sucrose phosphorylases (SPase) have shown promise in achieving higher yields. To enhance AA-2G synthesis, we screened and identified the SPase from Bifidobacterium longum (BlSPase) as the starting enzyme, with an optimal pH of 5.

Methylene Blue Has Strong Extracellular Virucidal Activity Against a SARS-CoV-2-Related Pangolin Coronavirus with No Intracellular or In Vivo Efficacy.

Studies have demonstrated that methylene blue exhibits significant antiviral activity against SARS-CoV-2 or related coronaviruses at the cellular level, suggesting its potential as an anti-SARS-CoV-2 drug. Herein, we report that methylene blue does not exhibit noticeable antiviral activity in a lethal model involving SARS-CoV-2-related pangolin coronavirus GX_P2V (short_3UTR) infection in CAG-hACE2 transgenic mice. We employed plaque reduction assays and cell infection experiments to compare the extracellular virucidal activity of the compound and its ability to inhibit viral replication in cells to those of nirmatrelvir.

and experimental approaches for validating RNA editing events in transcriptomes.

As a typical RNA virus, SARS-CoV-2 is subjected to RNA editing in host cells. While some researchers believe that a traditional variant calling pipeline retrieves all true-positive RNA editing events from the transcriptome, others argue that conventional methods identify many false-positive sites. Here, I describe several additional and experimental approaches to validate the authenticity of RNA editing in SARS-CoV-2.

Outcome prediction comparison of ischaemic areas' radiomics in acute anterior circulation non-lacunar infarction.

The outcome prediction of acute anterior circulation non-lacunar infarction (AACNLI) is important for the precise clinical treatment of this disease. However, the accuracy of prognosis prediction is still limited. This study aims to develop and compare machine learning models based on MRI radiomics of multiple ischaemic-related areas for prognostic prediction in AACNLI.

Reclassification of thermal equilibrium phase-transitions in thermodynamic limit systems.

For relaxor-ferroelectrics and relaxor-ferromagnets, the initial Ehrenfest-classification gives no phase-transition that contradicts the measured order-parameter, while the classification according to order-parameter and its derivatives raises the question about the relationships between the phase-transition and the specific-heat peak above and near the transition temperature. Here, based on the free-energy (F) of the thermodynamic limit systems when the external-field (h) tends 0, thermal equilibrium phase-transitions of thermodynamic limit systems with temperature (T) are reclassified into: (1) Discontinuous phase-transition. [Formula: see text] and [Formula: see text] have discontinuities in a T range; (2) Continuous phase-transition.

FBXO46 negatively regulates p53 activity by stabilizing Mdm2.

The tumor suppressor p53 plays a central role in suppressing tumor formation. Mouse double minute 2 homolog (Mdm2) serves as the principal ubiquitin E3 ligase responsible for the ubiquitination and subsequent degradation of p53. However, the regulatory mechanisms governing the Mdm2-p53 pathway are not comprehensively understood.

Guideline for the Prevention and Treatment of Metabolic Dysfunction-associated Fatty Liver Disease (Version 2024).

With the rising epidemic of obesity, metabolic syndrome, and type 2 diabetes mellitus in China, metabolic dysfunction-associated non-alcoholic fatty liver disease has become the most prevalent chronic liver disease. This condition frequently occurs in Chinese patients with alcoholic liver disease and chronic hepatitis B. To address the impending public health crisis of non-alcoholic fatty liver disease and its underlying metabolic issues, the Chinese Society of Hepatology and the Chinese Medical Association convened a panel of clinical experts to revise and update the "Guideline of prevention and treatment of non-alcoholic fatty liver disease (2018, China)".

Differences in cell subsets between sun-exposed and unexposed skin: preliminary single-cell sequencing and biological analysis from a single case.

Introduction: The composition and subsets of skin cells continuously change in a dynamic manner. However, the specific microcosmic alterations of human photoaged skin, independent of chronologic aging, remain unclear and have been infrequently analyzed. This study aimed to evaluate the biological processes and mechanisms underlying cell-subgroup alterations in skin photoaging.