Histological Outcome of Fuzheng Huayu plus Entecavir Combination Therapy in Chronic Hepatitis B Patients with Significant Liver Fibrosis.

To evaluate the efficacy of Fuzheng Huayu (FZHY), a Chinese herbal formula, plus entecavir (ETV) in regression of liver fibrosis in chronic hepatitis B (CHB) patients with significant fibrosis/cirrhosis. The current study was a two-center, randomized, double-blind and placebo-controlled pilot study. Fifty-two currently untreated chronic hepatitis B patients with Ishak fibrosis score ≥3 points were identified and 1:1 randomized into FZHY plus ETV combination and placebo plus ETV groups.

Aclidinium inhibits proliferation and metastasis of ovarian cancer SKOV3 cells via downregulating PI3K/AKT/mTOR signaling pathway.

Aclidinium, a muscarinic antagonist, is generally used to treat the respiratory system diseases whereas it is not clear whether aclidinium has therapeutic effect in ovarian cancer (OC). The aim of this study was to investigate the impact of aclidinium on OC and its potential mechanism. CCK-8 was employed to test the potential effect of aclidinium on SKOV3 cell proliferation.

Association Between Non-Steroidal Anti-Inflammatory Drug Use and Cognitive Decline: A Systematic Review and Meta-Analysis of Prospective Cohort Studies.

Background: Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly used medications in the elderly. They have been widely studied as possible preventive agents against cognitive decline because of the properties of anti-inflammatories, which sustain cerebral blood flow and mitigate the neurotoxicity of microglial cells. However, the results remain controversial.

Correlation between circulating miR-122 and prognosis of chronic HBV-related liver failure.

Objective: To assess the correlation between circulating microRNA (miR)-122 level and the prognosis of chronic hepatitis B-related liver failure (CHBLF).

Methods: Serum miR-122 from CHBLF patients (n = 6) and healthy controls (n = 6) was quantified using an Exiqon locked nucleic acid microarray. Quantitative real-time polymerase chain reaction was utilized to determine serum miR-122 expression in 102 patients with different liver diseases [CHBLF (n = 58), acute hepatitis B (n = 10), chronic hepatitis B (n = 22) and hepatitis B-related cirrhosis (n = 12)] and 23 healthy controls.

Association of cholesterol with risk of pancreatic cancer: a meta-analysis.

Aim: To evaluate the effect of dietary cholesterol and serum total cholesterol (TC) on the risk of pancreatic cancer.

Methods: A literature search was performed up to June 2014 in PubMed, EMBASE, China National Knowledge Infrastructure and China Biology Medical literature database for relevant articles published in English or Chinese. Pooled relative risks (RRs) with 95% confidence intervals (CIs) were calculated with a random-effects model.

[Clinical and pathological features in 138 cases of drug-induced liver injury].

Objective: To explore the categories of drugs causing hepatotoxicity and analyze the clinical and histological features of the corresponding drug-induced liver injury (DILI), in order to gain insights into potential diagnostic factors for DILI.

Methods: A total of 138 DILI patients treated at our hospital from April 2008 to April 2010 were retrospectively analyzed. The responsible drug for each DILI case was recorded.

Anodic oxidation process for the degradation of 2, 4-dichlorophenol in aqueous solution and the enhancement of biodegradability.

Degradation of 2, 4-dichlorophenol (2, 4-DCP) in aqueous media by anodic oxidation using Ti-based oxide electrode has been studied. Additionally, the influence of anodic oxidation on the biodegradability of 2, 4-DCP solution was investigated. It was found that alkaline media was suitable for the anodic oxidation of 2, 4-DCP, while acidic media tended to cause more 2, 4-DCP volatizing.

[Removal of pentachlorophenol catalyzed by immobilized horseradish peroxidase].

The removal of PCP using HRP immobilized by Fe3O4 sorption-gelatin embedding-cross linkage method as catalyzer was studied. Reaction conditions including the reacting time, different buffer systems and pH value, PCP initial concentration, HRP dosage were discussed in detail compared with free HRP. The results indicate that the equilibrium time of PCP removal reaction catalyzed by immobilized HRP is about 30 min, which is as fast as free HRP.

Double fluorescence conversion in ultraviolet and visible region for some praseodymium complexes of aromatic carboxylates.

Four praseodymium complexes of aromatic carboxylates (benzoate, 4-tert-butylbenzoate, 2-benzoylbe-noate, and benzimidazole-5-carboxylate) have been synthesized and characterized, whose photophysical properties have been studied with ultraviolet spectra, phosphorescence spectra, and fluorescence spectra. The fluorescent emission spectra of all praseodymium complexes show two emission peaks under the excitation band of 245 nm at about 395 and 595 nm respectively, while one peak under 415 nm at about 595 nm, which attributed to be 1S0 --> 1I6 (395 nm) transition and the characteristic emission 1D2 --> 3H4 (595 nm) transition of Pr3+ ion. The 1S0 --> 1I6 transition can be ascribed as the transition of charge transfer state, and the 1D2 --> 3H4 can be further proved that there exists an antenna effect in the fluorescence of praseodymium with aromatic carboxylic acids.