Improving the performance of polylactic acid/polypropylene/cotton stalk fiber composites with epoxidized soybean oil as a high efficiency plasticizer.

Polylactic acid (PLA) can serve as a biodegradable alternative to traditional petroleum-based plastics, but its poor impact resistance and high production costs limit its applications. In this study, different contents of epoxidized epoxy soybean oil (ESO) were added as plasticizer to melt blend with polylactic acid (PLA), polypropylene (PP) and cotton stalk fiber (CSF), examining its impact on the mechanical properties, thermal stability, microstructure, and crystallization behavior of the blends. The results indicated that ESO reacted with PLA and CSF to form branched polymers and microgels.

Molecular signaling pathways in doxorubicin-induced nephrotoxicity and potential therapeutic agents.

Doxorubicin (DOX), an anthracycline chemotherapeutic agent, is extensively utilized in the clinical management of both solid and hematological malignancies. Nevertheless, the clinical application of this treatment is significantly limited by adverse reactions and toxicity that may arise during or after administration. Its cytotoxic effects are multifaceted, with cardiotoxicity being the most prevalent side effect.

Elucidating the pathophysiology of polycystic ovary syndrome: Construction and analysis of a ceRNA network in cumulus cells.

Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder with elusive molecular mechanisms. This study explores the competitive endogenous RNA (ceRNA) regulatory network in the cumulus cells of PCOS patients. ceRNAs are transcripts like mRNAs, miRNAs, and lncRNAs that competitively bind shared miRNAs, regulating gene expression post-transcriptionally.

Correction: Cu(II)-Mediated aerobic oxidative synthesis of sulfonated chromeno[4,3-]pyrazol-4(2)-ones.

Correction for 'Cu(II)-Mediated aerobic oxidative synthesis of sulfonated chromeno[4,3-]pyrazol-4(2)-ones' by Quan Zhou , , 2022, , 5575-5581, https://doi.org/10.1039/D2OB00639A.

Progranulin deficiency associates with postmenopausal osteoporosis via increasing ubiquitination of estrogen receptor α.

Estrogen deficiency is considered the most important cause of postmenopausal osteoporosis. However, the underlying mechanism is still not completely understood. In this study, progranulin (PGRN) was isolated as a key regulator of bone mineral density in postmenopausal women through high throughput proteomics screening.

Precision Structuring of Free-Text Surgical Record for Enhanced Stroke Management: A Comparative Evaluation of Large Language Models.

Introduction: Mechanical thrombectomy (MTB) is a critical procedure for acute ischemic stroke (AIS) patients. However, the free-text format of MTB surgical records limits the formulation of effective postoperative patient management and rehabilitation plans. This study compares the efficacy of large language models (LLMs) in structuring data from these free-text MTB surgical record.

Short-Photoperiod Induces Floral Induction Involving Carbohydrate Metabolism and Regulation by VcCO3 in Greenhouse Blueberry.

Blueberry flower buds cultivated in greenhouses develop during both autumn and spring, with floral induction being a critical process for flowering, influenced by environmental factors. This study aimed to clarify the regulatory mechanisms governing floral induction in greenhouse blueberries, focusing on the similarities and differences in flower bud differentiation between the spring and autumn seasons. Understanding these mechanisms is pivotal for enhancing blueberry production.

Predicting individual patient and hospital-level discharge using machine learning.

Background: Accurately predicting hospital discharge events could help improve patient flow and the efficiency of healthcare delivery. However, using machine learning and diverse electronic health record (EHR) data for this task remains incompletely explored.

Methods: We used EHR data from February-2017 to January-2020 from Oxfordshire, UK to predict hospital discharges in the next 24 h.

Anthropogenic land consolidation intensifies zoonotic host diversity loss and disease transmission in human habitats.

Anthropogenic land-use change is an important driver of global biodiversity loss and threatens public health through biological interactions. Understanding these landscape-ecological effects at local scales will help achieve the United Nations Sustainable Development Goals by balancing urbanization, biodiversity and the spread of infectious diseases. Here, we address this knowledge gap by analysing a 43-year-long monthly dataset (1980-2022) of synanthropic rodents in Central China during intensive land-use change.

Herqupenoid A, an Unparalleled Sesquiterpene-Quinone Hybrid Featuring a Multicyclic Caged 2,7-Dioxatetracyclo[5.4.0.0.0]Hendecane Fragment from .

Herqupenoid A (), a sesquiterpene-quinone hybrid with an unparalleled 5/5/6/5-fused ring skeleton based on a multicyclic caged 2,7-dioxatetracyclo[5.4.0.

The relationship between HBV antigens deposition in kidneys and renal prognosis in IgA nephropathy patients infected with HBV.

Background: Hepatitis B virus (HBV) is a risk factor for the progression of immunoglobulin A (IgA) nephropathy. The effect of HBV antigens deposition in kidneys and treatment influencing HBV deposition requires further investigation.

Methods: We analyzed 198 patients with IgAN, including 99 patients with HBV infection and 99 propensity score-matched patients without HBV infection.

Economic evaluation of treating invasive aspergillosis with isavuconazole, posaconazole and voriconazole in China.

To assess the cost-effectiveness of treating invasive aspergillosis with isavuconazole, posaconazole and voriconazole in China. A cost-consequence analysis (CCA) was conducted, considering both healthcare system and patient out-of-pocket perspectives. We considered the costs of medications, diagnostics and hospitalization and the consequences of mortality, response rate and adverse events.

The effects of acetylated cordycepin derivatives on promoting vascular angiogenesis and attenuating myocardial ischemic injury.

Background: Enhanced angiogenesis following myocardial infarction (MI) is beneficial to preserve cardiac function. The present study aimed to investigate whether acetylated derivatives of cordycepin altered its original antitumor properties and exerted cardioprotective effects by promoting angiogenesis and .

Methods: Cordycepin and its derivatives with single (DA), double (DAA), and triple acetyl groups (DAAA) were assessed.

Enhanced Chirality Transfer in Self-Assembled Nanocomposites Powered by A Trace Amount of Chiral Dimeric Molecules.

Chiral-selective self-assembly has markedly advanced the development of chiral materials. While the Sergeant and Soldiers principle allows for chirality amplification, it necessitates precise shape-matching between chiral and achiral molecules, leading to a low chirality transfer efficiency-where one chiral molecule influences the chirality of a limited number of achiral molecules. Here, we show that this efficiency can be markedly enhanced by introducing chiral dimeric molecules.

DLGAP3 suppresses malignant behaviors of glioma cells via inhibiting RGS12-mediated MAPK/ERK signaling.

Background: Glioma is the most common malignant tumor of the central nervous system, and is characterized by high recurrence, poor prognosis and especially complex pathogenesis. The synaptic plasticity-related protein DLGAP3 is mainly involved in the assembly and function of postsynaptic density complex. It's widely known that DLGAP3 participating in the occurrence of various neuropsychiatric diseases, but its role in glioma tumorigenesis remains largely unclear.

MicroRNA-mediated autophagy and drug resistance in cancer: mechanisms and therapeutic strategies.

This paper provides an exhaustive overview of the intricate interplay between microRNAs (miRNAs) and autophagy in the context of human cancers, underscoring the pivotal role these non-coding RNAs play in modulating autophagic pathways and their implications for cancer development, progression, and resistance to therapy. MiRNAs, as critical regulators of gene expression post-transcription, influence various biological processes, including autophagy, a catabolic mechanism essential for cellular homeostasis, stress response, and survival. The review meticulously delineates the mechanisms through which miRNAs impact autophagy by targeting specific genes and signaling pathways, thereby affecting cancer cell proliferation, metastasis, and response to chemotherapy.

A cross-sectional study of fundus lesion characteristics in patients with acute visual impairment caused by COVID-19 infection.

To investigate the characteristics of acute visual dysfunction and fundus lesions in patients with COVID-19 pneumonia. A retrospective case series study was conducted. Data from 48 patients (96 eyes) with COVID-19 infection who presented to our ophthalmology department with acute onset visual disturbance between December 5, 2022, and February 28, 2023 were collected.

Pulmonary delivery of dual-targeted nanoparticles improves tumor accumulation and cancer cell targeting by restricting macrophage interception in orthotopic lung tumors.

Despite the recognized potential of inhaled nanomedicines to enhance and sustain local drug concentrations for lung cancer treatment, the influence of macrophage uptake on targeted nanoparticle delivery to and within tumors remains unclear. Here, we developed three ligand-coated nanoparticles for pulmonary delivery in lung cancer therapy: phenylboronic acid-modified nanoparticles (PBA-NPs), PBA combined with folic acid (FA-PBA-NPs), and PBA with mannose (MAN-PBA-NPs). In vitro, MAN-PBA-NPs were preferentially internalized by macrophages, whereas FA-PBA-NPs exhibited superior uptake by cancer cells compared to macrophages.

Analysis on characteristics and multilocus sequence typing of Clostridium perfringens in western China.

Objectives: The objective of this study was to identify and analyse the distribution characteristics, toxin genotyping and antimicrobial susceptibility of Clostridium perfringens and to investigate its resistance mechanisms and genetic characteristics.

Methods: The MICs of various antibiotics against C. perfringens were determined using the agar dilution method, and resistance genes and toxin genotypes were detected by PCR.