Analysis of risk factors determining prognosis of cutaneous squamous-cell carcinoma: a prospective study.

Background: Cutaneous squamous-cell carcinomas (SCC) are among the most common cancers capable of metastasis. Current Tumour Node Metastasis (TNM) staging includes horizontal tumour size, involvement of extradermal structures, and degree of differentiation. The aim of this study was to prospectively analyse the key factors predicting metastasis and local recurrence in cutaneous SCC.

Anaphylactic reaction to bovine serum albumin after embryo transfer.

Objective: To increase the awareness of bovine serum albumin (BSA) sensitivity as a potentially lethal complication during ET.

Design: Case report.

Setting: Routine ET in university hospital.

[Subcutaneous infusion anesthesia with prilocaine diluted with Ringer's lactate].

Background: Dermatologic surgery is usually possible under local anesthesia, even when large amounts of highly diluted anesthetic solutions are required (tumescent anesthesia). Although special pumps now render such large injections effortless, it is usually still necessary to hold and guide the injection cannula. We have overcome this handicap by injecting anesthetic solutions slowly with an infusomat, which allows slow painless automatic infusion into the subcutaneous layer.

Slow infusion tumescent anesthesia.

Background: Dermatologic surgery is usually possible under local anesthesia, even when large amounts of highly diluted anesthetic solution are required (tumescent anesthesia). Although special pumps now render such large injections effortless, it is usually still necessary to hold and guide the injection cannula.

Objective: We have found it possible to overcome this handicap by injecting anesthetic solutions slowly with a common infusomat, as in paravenous infusion, into the subcutaneous layer.

[Bullous pemphigoid as a paraneoplastic syndrome. A case report in renal-cell carcinoma].

Paraneoplastic markers in tumor patients may occur at various stages of the disease. While some disorders almost invariably herald an underlying malignancy (obligative marker), most only occasionally do so (facultative marker). The association of bullous pemphigoid with malignancy is controversial.

[Extensive rodent ulcer (type: solid basal cell carcinoma)].

A 52 year old female had a large destructive basal cell carcinoma of the back measuring 27 cm in diameter. There was destruction of the vertebral bodies, envelopment of the medullary cone, early spinal compression and soft tissue spread into the retroperitoneum. Early neurological defects were present.

Systemic scleroderma. Multicenter trial of 1 year of treatment with recombinant interferon gamma.

Objective: To confirm significant improvement of the skin score in systemic sclerosis by treatment with interferon gamma in a larger group of patients and to investigate on a molecular level the influence of interferon gamma on collagen type I messenger RNA expression.

Design: Open, noncontrolled multicenter study.

Setting: Five outpatient clinics specializing in the care of systemic scleroderma.

Double-blind, placebo-controlled study of intralesional interferon gamma for the treatment of localized scleroderma.

Background: Localized scleroderma is characterized by circumscribed fibrotic plaques and may progress to widespread skin involvement and fibrosis. Interferon gamma (IFN-gamma) has been shown to be a potent inhibitor of collagen synthesis and of the migration and proliferation of dermal fibroblasts.

Objective: Our purpose was to determine whether IFN-gamma is effective in the treatment of localized scleroderma.

[Exacerbation of pustular psoriasis in mercury poisoning].

A patient suffering from long-standing pustular psoriasis of the palms was treated for 3 weeks with a mercury-containing drug. Exacerbation into generalized pustular psoriasis developed. Mercury levels in blood and urine were increased.