Publications by authors named "Weekai Chia"
Article Synopsis
- Human idiopathic hypercalciuria (IH) is a leading cause of kidney stones due to imbalanced calcium metabolism, which is mimicked in a rat model known as GHS.
- This study investigates how the vitamin D receptor (VDR) influences genes related to calcium regulation in GHS rats, noting increased VDR levels particularly in certain tissues.
- The findings indicate that VDR might enhance the expression of key calcium-related genes through specific binding to their promoters and epigenetic changes, contributing to the development of hypercalciuria.
Osteogenesis (OS) is a type of differentiation that is of great importance for bone homeostasis. Increasing studies suggest circular RNAs (circRNAs) as pivotal regulators in OS. This study proposed to investigate mechanism mediated by circRNAs in OS.
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