Shared genetic background between children and adults with attention deficit/hyperactivity disorder.

Attention deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by age-inappropriate symptoms of inattention, impulsivity, and hyperactivity that persist into adulthood in the majority of the diagnosed children. Despite several risk factors during childhood predicting the persistence of ADHD symptoms into adulthood, the genetic architecture underlying the trajectory of ADHD over time is still unclear. We set out to study the contribution of common genetic variants to the risk for ADHD across the lifespan by conducting meta-analyses of genome-wide association studies on persistent ADHD in adults and ADHD in childhood separately and jointly, and by comparing the genetic background between them in a total sample of 17,149 cases and 32,411 controls.

Search for direct pair production of supersymmetric partners to the lepton in proton-proton collisions at .

A search is presented for slepton pairs produced in proton-proton collisions at a center-of-mass energy of 13 . The search is carried out in events containing two leptons in the final state, on the assumption that each slepton decays primarily to a lepton and a neutralino. Events are considered in which each lepton decays to one or more hadrons and a neutrino, or in which one of the leptons decays instead to an electron or a muon and two neutrinos.

Hippo-YAP1 Is a Prognosis Marker and Potentially Targetable Pathway in Advanced Gallbladder Cancer.

Gallbladder cancer is an aggressive disease with late diagnosis and no efficacious treatment. The Hippo-Yes-associated protein 1 (YAP1) signaling pathway has emerged as a target for the development of new therapeutic interventions in cancers. However, the role of the Hippo-targeted therapy has not been addressed in advanced gallbladder cancer (GBC).

A multi-dimensional search for new heavy resonances decaying to boosted , , or boson pairs in the dijet final state at 13 .

A search in an all-jet final state for new massive resonances decaying to , , or boson pairs using a novel analysis method is presented. The analysis is performed on data corresponding to an integrated luminosity of 77.3 recorded with the CMS experiment at the LHC at a centre-of-mass energy of 13  .

Digital Workflow for Implant Rehabilitation with Double Full-Arch Monolithic Zirconia Prostheses.

The purpose of the present report is to illustrate a proof-of-concept protocol with the double digital scanning (DDS) technique for complete digital workflow in double full-arch implant rehabilitation. Two patients (4 restored arches) presented with hopeless dentitions and they were treated with a 4-appointment prosthodontic protocol and monolithic zirconia prostheses implementing a complete digital workflow. The outcomes are presented after clinical and radiographic observation for 2 years.

Search for production of four top quarks in final states with same-sign or multiple leptons in proton-proton collisions at .

The standard model (SM) production of four top quarks ( ) in proton-proton collisions is studied by the CMS Collaboration. The data sample, collected during the 2016-2018 data taking of the LHC, corresponds to an integrated luminosity of 137 at a center-of-mass energy of 13 . The events are required to contain two same-sign charged leptons (electrons or muons) or at least three leptons, and jets.

Strain predicts left ventricular functional recovery after acute myocardial infarction with systolic dysfunction.

Objective: Regional and global longitudinal strain (RLS-GLS) are considered reliable indexes of myocardial viability in chronic ischemic patients and prediction of left ventricular (LV) functional recovery after acute myocardial infarction (MI) with preserved left ventricular ejection fraction (LVEF). We tested in the present study whether RLS and GLS could also identify transmural extent of myocardial scar and predict LV functional recovery and remodeling in patients with reduced LVEF after acute MI.

Methods: Echocardiography and late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) were performed in 71 patients with reduced LVEF (≤45%) after acute MI treated with acute percutaneous coronary intervention.

Digitally enabled aged care and neurological rehabilitation to enhance outcomes with Activity and MObility UsiNg Technology (AMOUNT) in Australia: A randomised controlled trial.

Background: Digitally enabled rehabilitation may lead to better outcomes but has not been tested in large pragmatic trials. We aimed to evaluate a tailored prescription of affordable digital devices in addition to usual care for people with mobility limitations admitted to aged care and neurological rehabilitation.

Methods And Findings: We conducted a pragmatic, outcome-assessor-blinded, parallel-group randomised trial in 3 Australian hospitals in Sydney and Adelaide recruiting adults 18 to 101 years old with mobility limitations undertaking aged care and neurological inpatient rehabilitation.

Early exercise training feasibility after aortic valve repair: A multicentre prospective French survey on behalf of the Aortic Valve repair International Registry (AVIATOR).

Background: Standardization of aortic valve repair by the external ring annuloplasty approach is an alternative to valve replacement to avoid prosthetic valve-related events. Although the benefit of exercise training to improve postoperative exercise tolerance has been demonstrated in many conditions after cardiac surgery, it has never been described after aortic valve repair.

Objectives: To evaluate the feasibility of an early exercise training programme after aortic valve repair.

Pd/BIPHEPHOS is an Efficient Catalyst for the Pd-Catalyzed -Allylation of Thiols with High -Selectivity.

The Pd-catalyzed -allylation of thiols with stable allylcarbonate and allylacetate reagents offers several advantages over established reactions for the formation of thioethers. We could demonstrate that Pd/BIPHEPHOS is a catalyst system which allows the transition metal-catalyzed -allylation of thiols with excellent -regioselectivity. Mechanistic studies showed that this reaction is reversible under the applied reaction conditions.

Search for Supersymmetry with a Compressed Mass Spectrum in Events with a Soft τ Lepton, a Highly Energetic Jet, and Large Missing Transverse Momentum in Proton-Proton Collisions at sqrt[s]=13 TeV.

The first search for supersymmetry in events with an experimental signature of one soft, hadronically decaying τ lepton, one energetic jet from initial-state radiation, and large transverse momentum imbalance is presented. These event signatures are consistent with direct or indirect production of scalar τ leptons (τ[over ˜]) in supersymmetric models that exhibit coannihilation between the τ[over ˜] and the lightest neutralino (χ[over ˜]_{1}^{0}), and that could generate the observed relic density of dark matter. The data correspond to an integrated luminosity of 77.

Searches for physics beyond the standard model with the variable in hadronic final states with and without disappearing tracks in proton-proton collisions at .

Two related searches for phenomena beyond the standard model (BSM) are performed using events with hadronic jets and significant transverse momentum imbalance. The results are based on a sample of proton-proton collisions at a center-of-mass energy of , collected by the CMS experiment at the LHC in 2016-2018 and corresponding to an integrated luminosity of 137 . The first search is inclusive, based on signal regions defined by the hadronic energy in the event, the jet multiplicity, the number of jets identified as originating from bottom quarks, and the value of the kinematic variable for events with at least two jets.

Extraction and validation of a new set of CMS pythia8 tunes from underlying-event measurements.

New sets of CMS underlying-event parameters ("tunes") are presented for the pythia8 event generator. These tunes use the NNPDF3.1 parton distribution functions (PDFs) at leading (LO), next-to-leading (NLO), or next-to-next-to-leading (NNLO) orders in perturbative quantum chromodynamics, and the strong coupling evolution at LO or NLO.

Digital workflow: In vitro accuracy of 3D printed casts generated from complete-arch digital implant scans.

Statement Of Problem: Data on the accuracy of printed casts from complete-arch digital implant scans are lacking.

Purpose: The purpose of this in vitro study was to compare the 3D accuracy of printed casts from a complete-arch digital implant intraoral scan with stone casts from conventional impressions.

Material And Methods: An edentulous mandibular cast with 4 multiunit abutments with adequate anteroposterior spread was used as the master cast.

Search for Physics beyond the Standard Model in Events with Overlapping Photons and Jets.

Results are reported from a search for new particles that decay into a photon and two gluons, in events with jets. Novel jet substructure techniques are developed that allow photons to be identified in an environment densely populated with hadrons. The analyzed proton-proton collision data were collected by the CMS experiment at the LHC, in 2016 at sqrt[s]=13  TeV, and correspond to an integrated luminosity of 35.

Measurement of the average very forward energy as a function of the track multiplicity at central pseudorapidities in proton-proton collisions at .

The average total energy as well as its hadronic and electromagnetic components are measured with the CMS detector at pseudorapidities in proton-proton collisions at a centre-of-mass energy . The results are presented as a function of the charged particle multiplicity in the region . This measurement is sensitive to correlations induced by the underlying event structure over a very wide pseudorapidity region.

Measurements of triple-differential cross sections for inclusive isolated-photon+jet events in collisions at .

Measurements are presented of the triple-differential cross section for inclusive isolated-photon+jet events in collisions at TeV as a function of photon transverse momentum ( ), photon pseudorapidity ( ), and jet pseudorapidity ( ). The data correspond to an integrated luminosity of that probe a broad range of the available phase space, for and , , , and jet transverse momentum, , > 25 . The measurements are compared to next-to-leading order perturbative quantum chromodynamics calculations, which reproduce the data within uncertainties.

Search for Low-Mass Quark-Antiquark Resonances Produced in Association with a Photon at sqrt[s]=13 TeV.

A search for narrow low-mass resonances decaying to quark-antiquark pairs is presented. The search is based on proton-proton collision events collected at 13 TeV by the CMS detector at the CERN LHC. The data sample corresponds to an integrated luminosity of 35.

Anxiety risk SNPs on chromosome 2 modulate arousal in children in a fear generalization paradigm.

Alterations in fear learning/generalization are considered to be relevant mechanisms engendering the development of anxiety disorders being the most prevalent mental disorders. Although anxiety disorders almost exclusively have their first onset in childhood and adolescence, etiological research focuses on adult individuals. In this study, we evaluated findings of a recent meta-analysis of genome-wide association studies in adult anxiety disorders with significant associations of four single nucleotide polymorphisms (SNPs) in a large cohort of 347 healthy children (8-12 years) characterized for dimensional anxiety.

Effect of time in function on the predictability of short dental implants (≤6 mm): A meta-analysis.

Purpose: To analyse randomised controlled clinical trials (RCTs) and prospective cohort studies reporting on the survival and failure rates of functionally loaded short implants (SI) based on the actual length of time in function.

Materials And Methods: This meta-analysis was conducted according to PRISMA guidelines for systematic reviews. Electronic and manual searches were conducted to identify RCTs and prospective cohort studies reporting survival and complication rates of short dental implants (≤6 mm) based on the time in function.

Deciphering the enzymatic mechanism of sugar ring contraction in UDP-apiose biosynthesis.

D-Apiose is a -branched pentose sugar important for plant cell wall development. Its biosynthesis as UDP-D-apiose involves decarboxylation of the UDP-D-glucuronic acid precursor coupled to pyranosyl-to-furanosyl sugar ring contraction. This unusual multistep reaction is catalyzed within a single active site by UDP-D-apiose/UDP-D-xylose synthase (UAXS).

Highly Efficient and Reversible Covalent Patterning of Graphene: 2D-Management of Chemical Information.

Patterned graphene-functionalization with a tunable degree of functionalization can tailor the properties of graphene. Here, we present a new reductive functionalization approach combined with lithography rendering patterned graphene-functionalization easily accessible. Two types of covalent patterning of graphene were prepared and their structures were unambiguously characterized by statistical Raman spectroscopy together with scanning electron microscopy/energy-dispersive X-ray spectroscopy (SEM-EDS).