β-glucan Exposure on the Fungal Cell Wall Tightly Correlates with Competitive Fitness of Species in the Mouse Gastrointestinal Tract.

is responsible for ~400,000 systemic fungal infections annually, with an associated mortality rate of 46-75%. The human gastrointestinal (GI) tract represents the largest natural reservoir of species and is a major source of systemic fungal infections. However, the factors that control GI colonization by species are not completely understood.

Predicting peptide binding affinities to MHC molecules using a modified semi-empirical scoring function.

The Major Histocompatibility Complex (MHC) plays an important role in the human immune system. The MHC is involved in the antigen presentation system assisting T cells to identify foreign or pathogenic proteins. However, an MHC molecule binding a self-peptide may incorrectly trigger an immune response and cause an autoimmune disease, such as multiple sclerosis.

Predicting peptide binding to Major Histocompatibility Complex molecules.

The Major Histocompatibility Complex (MHC) constitutes an important part of the human immune system. During infection, pathogenic proteins are processed into peptide fragments by the antigen processing machinery. These peptides bind to MHC molecules and the MHC-peptide complex is then transported to the cell membrane where it elicits an immune response via T-cell binding.