Fasting plasma glucose is not sufficient to detect ongoing glucose intolerance after pregnancy complicated by gestational diabetes.

Aims: Women who develop diabetes during pregnancy are at significant risk of developing Type 2 diabetes later in life, and "should be offered blood glucose testing ...

Pulmonary rehabilitation for chronic obstructive pulmonary disease: a pilot study evaluating a once-weekly versus twice-weekly supervised programme.

Objectives: To compare the effectiveness of a once-weekly supervised pulmonary rehabilitation programme with a standard twice-weekly format.

Design: Randomised trial of equivalency.

Setting: Pulmonary rehabilitation service of a primary care trust delivered at two physiotherapy outpatient departments.

Bridging the gender gap: interventions with aggressive girls and their parents.

In response to a gap in gender-sensitive programming for young aggressive girls (5-11) and their families, the SNAP Girls Connection (GC) was developed in 1996. This multi-systemic intervention is built on a developmental model of risk and protective factors within the girl and her relationships. We evaluated the SNAP(R) GC using a prospective quasi-experimental design, randomly assigning 80 girls to treatment (N = 45) and waiting-list groups (N = 35) over 2 years.

New insights into the function of Atg9.

Autophagy is a lysosomal degradation pathway that is essential for cellular homeostasis. Identification of more than 30 autophagy related proteins including a multi-spanning membrane protein, Atg9, has increased our understanding of the molecular mechanisms involved in autophagy. Atg9 is required for autophagy in several eukaryotic organisms although its function is unknown.

Inhibiting tumor growth by targeting tumor vasculature with galectin-1 antagonist anginex conjugated to the cytotoxic acylfulvene, 6-hydroxylpropylacylfulvene.

Targeted delivery of therapeutic drugs promises to become the norm to treat cancer. Here, we conjugated the cytotoxic agent 6-hydroxypropylacylfulvene (HPAF) to anginex, a peptide that targets galectin-1, which is highly expressed in endothelial cells of tumor vessels. In a human ovarian cancer model in mice, the conjugate inhibited tumor growth better than equivalent doses of either compound alone.

Coordinated regulation of autophagy by p38alpha MAPK through mAtg9 and p38IP.

Autophagy, a lysosomal degradation pathway, is essential for homeostasis, development, neurological diseases, and cancer. Regulation of autophagy in human disease is not well understood. Atg9 is a transmembrane protein required for autophagy, and it has been proposed that trafficking of Atg9 may regulate autophagy.

multiplierz: an extensible API based desktop environment for proteomics data analysis.

Background: Efficient analysis of results from mass spectrometry-based proteomics experiments requires access to disparate data types, including native mass spectrometry files, output from algorithms that assign peptide sequence to MS/MS spectra, and annotation for proteins and pathways from various database sources. Moreover, proteomics technologies and experimental methods are not yet standardized; hence a high degree of flexibility is necessary for efficient support of high- and low-throughput data analytic tasks. Development of a desktop environment that is sufficiently robust for deployment in data analytic pipelines, and simultaneously supports customization for programmers and non-programmers alike, has proven to be a significant challenge.

Thyrotropin receptor activation increases hyaluronan production in preadipocyte fibroblasts: contributory role in hyaluronan accumulation in thyroid dysfunction.

The thyrotropin receptor (TSHR) is expressed during lineage-specific differentiation (e.g. adipogenesis) and is activated by TSH, thyroid-stimulating antibodies, and gain-of-function mutations (TSHR*).

Modulation of TGFbeta1-dependent myofibroblast differentiation by hyaluronan.

Myofibroblasts are contractile cells that are characterized by the expression of alpha-smooth muscle actin and mediate the closure of wounds and the formation of collagen-rich scars. Their presence in organs such as lungs, liver, and kidney has long been established as a marker of progressive fibrosis. The transforming growth factor beta(1)-driven differentiation of fibroblasts is a major source of myofibroblasts, and recent data have shown that hyaluronan is a major modulator of this process.

Standardizing the nomenclature for clonal lineages of the sudden oak death pathogen, Phytophthora ramorum.

Phytophthora ramorum, the causal agent of sudden oak death and ramorum blight, is known to exist as three distinct clonal lineages which can only be distinguished by performing molecular marker-based analyses. However, in the recent literature there exists no consensus on naming of these lineages. Here we propose a system for naming clonal lineages of P.

Fate of Libby amphibole fibers when burning contaminated firewood.

In Libby, Montana, over 70 years of mining amphibole-contaminated vermiculite has led to amphibole contamination in areas surrounding the abandoned mine and in other areas throughout the town. In addition to contaminated soils, tree bark has also been found to be contaminated with amphibole fibers throughout the Libby area. As residential woodstoves are the main source of home heating in Libby, the purpose of this study was to determine if amphibole fibers become liberated into the ambient air when amphibole-contaminated firewood is combusted.

Molecular characterisation of two novel double-stranded RNA elements from Phlebiopsis gigantea.

The incomplete sequences of two large, 10-12 kbp, double-stranded RNAs (dsRNAs) found in the TW-2 isolate of the saprophytic fungus, Phlebiopsis gigantea (Pg) are reported. Both PgV-TW2 dsRNA1 and dsRNA2 potentially encode fusion proteins which are apparently expressed by a translational frameshifting mechanism. The C-terminal region of both predicted proteins was 21% identical and contained the eight motifs conserved in RNA-dependent RNA polymerases of dsRNA mycoviruses and had highest similarity with members of the family Totiviridae, but possibly do not form virions.

Building capacity for nurse-led research.

Aim: To discuss factors that have influenced the development of research capacity among nurses in lower and middle-income countries (LMICs).

Background: Concerned health scientists have addressed the importance of building research capacity among health professionals. Strengthening capacity specifically among LMIC nurses has been infrequently discussed.

Hyaluronan orchestrates transforming growth factor-beta1-dependent maintenance of myofibroblast phenotype.

The differentiation of resident fibroblasts to myofibroblasts is central to wound healing. In the context of organ fibrosis, however, persistence of these myofibroblasts is associated with progressive disease. This study examines mechanisms controlling the maintenance of the myofibroblast phenotype.

The cell migration molecule UNC-53/NAV2 is linked to the ARP2/3 complex by ABI-1.

The shape changes that are required to position a cell to migrate or grow out in a particular direction involve a coordinated reorganization of the actin cytoskeleton. Although it is known that the ARP2/3 complex nucleates actin filament assembly, exactly how the information from guidance cues is integrated to elicit ARP2/3-mediated remodeling during outgrowth remains vague. Previous studies have shown that C.

Randomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitis.

Background & Aims: Nonalcoholic steatohepatitis (NASH) is a leading cause of chronic liver disease for which there is limited therapy available. Insulin sensitizing, anti-inflammatory, and antifibrotic properties of thiazolidinediones support their use in treating NASH. We have evaluated pioglitazone in the treatment of nondiabetic patients with NASH.

A closed-loop cross-correlation method for detecting model mismatch in MIMO model-based controllers.

Correlation between a dithering signal and the prediction error has been used for detecting model mismatch in univariate model based control systems. This paper extends that approach to MIMO control systems. A closed-loop cross-correlation method is presented to detect which specific input-output pairings of a model-based controller are mismatched.

Separation and characterization of respirable amphibole fibers from Libby, Montana.

The vermiculite mine in Libby, Montana, was in operation for over 70 yr and was contaminated with asbestos-like amphibole fibers. The mining, processing, and shipping of this vermiculite led to significant fiber inhalation exposure throughout the community, and residents of Libby have developed numerous pulmonary diseases such as lung cancer and mesothelioma. The present study describes the separation of Libby 6-mix into respirable and nonrespirable size fractions by means of aqueous elutriation.

Forecasting emergence and movement of overwintering hazelnut big bud mites from big buds.

Eriophyoid big bud mites are key pests of hazelnut throughout the world, but they are difficult to control with chemicals or other methods because they are protected inside the bud. The most effective time for control is during the relatively short emergence period which is difficult for growers to predict. The key objectives of this study were to monitor mite emergence from big buds in spring, determine the phenology of mites in relation to tree phenology and weather, and identify the optimum timing for control measures.

Structural characterization of water/ice formation in SBA-15 silicas: III. The triplet profile for 86 Ã… pore diameter.

The diffraction results for the formation of ice in 86 Å diameter pores of a SBA-15 silica sample are analysed to provide information on the characteristics of the ice created in the pores. The asymmetric triplet at ∼1.7 Å(-1), which involves several overlapping peaks, is particularly relevant to the different ice phases and contains a number of components that can be individually identified.

Structural characterization of water and ice in mesoporous SBA-15 silicas: II. The 'almost-filled' case for 86Â Ã… pore diameter.

Neutron diffraction measurements for D(2)O in SBA-15 silica of pore diameter 86 Å have been made in a temperature range from 300 to 100 K. The pore-filling factor for the liquid phase is 0.95, resulting in an 'almost-filled' sample.