Publications by authors named "Weatherill J"

Nature-based Solutions (NbS) are widely advocated to have multiple benefits, including in flood risk reduction, water quality improvement and ecosystem health. There are, however, few empirical studies quantifying such multi-functionality. Given the ongoing pressures of flooding and poor water quality within Europe, there is an urgent need for empirical evidence to assess the potential for NbS features to address these issues.

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This report discusses the case of a 54-year-old woman with a complex psychiatric history including schizophrenia, tardive dyskinesia, borderline intellectual function, and congenital deafness that reported auditory and visual hallucinations during an acute exacerbation of schizophrenia. After resuming a previous lithium regimen and introducing olanzapine, the patient improved and was discharged without hallucinations. In our report we explore some of the challenges we faced, discuss similar cases, and examine the unresolved debate about whether congenitally deaf patients can experience auditory hallucinations.

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Disinfection byproduct (DBP) formation, prediction, and minimization are critical challenges facing the drinking water treatment industry worldwide where chemical disinfection is required to inactivate pathogenic microorganisms. Fluorescence excitation-emission matrices-parallel factor analysis (EEM-PARAFAC) is used to characterize and quantify fluorescent dissolved organic matter (FDOM) components in aquatic systems and may offer considerable promise as a low-cost optical surrogate for DBP formation in treated drinking waters. However, the global utility of this approach for quantification and prediction of specific DBP classes or species has not been widely explored to date.

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Natural ecosystems can become significant reservoirs and/or pathways for antimicrobial resistance (AMR) dissemination, with the potential to affect nearby microbiological, animal, and ultimately human communities. This is further accentuated in environments that provide direct human exposure, such as drinking water. To date, however, few studies have investigated AMR dissemination potential and the presence of co-selective stressors (e.

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The role of the natural environment in the dissemination of antimicrobial resistant bacteria has been increasingly recognised in the literature. However, knowledge surrounding the critical factors and mechanisms mediating their occurrence is still limited, particularly in relatively 'pristine' groundwater environments. In the Republic of Ireland (RoI), a country characterised by high groundwater reliance, household-based (unregulated) wells provide drinking water to 11% of the population.

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Groundwater is a vital drinking water resource and its protection from microbiological contamination is paramount to safeguard public health. The Republic of Ireland (RoI) is characterised by the highest incidence of verocytotoxigenic Escherichia coli (VTEC) enteritis in the European Union (EU), linked to high reliance on unregulated groundwater sources (~16% of the population). Yet, the spatio-temporal factors influencing the frequency and magnitude of microbial contamination remain largely unknown, with past studies typically constrained to spatio-temporally 'limited' sampling campaigns.

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Understanding interactions between iron (oxyhydr)oxide nanoparticles and plutonium is essential to underpin technology to treat radioactive effluents, in cleanup of land contaminated with radionuclides, and to ensure the safe disposal of radioactive wastes. These interactions include a range of adsorption, precipitation, and incorporation processes. Here, we explore the mechanisms of plutonium sequestration during ferrihydrite precipitation from an acidic solution.

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Antimicrobial resistance represents one of our most significant global health threats, with increasing incidences noted in both clinical and environmental settings. As such, identifying and understanding the sources and pathways for antimicrobial-resistant bacteria (ARB) is critical. The current study presents the first systematic review and pooled analysis of ARB occurrence in global groundwater supplies, which are used as primary drinking water sources by 2.

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Hyporheic zones are increasingly thought of as natural bioreactors, capable of transforming and attenuating groundwater pollutants present in diffuse baseflow. An underappreciated scenario in the understanding of contaminant fate in hyporheic zones is the interaction between point-source trichloroethene (TCE) plumes and ubiquitous, non-point source pollutants such as nitrate. This study aims to conceptualise critical biogeochemical gradients in the hyporheic zone which govern the export potential of these redox-sensitive pollutants from carbon-poor, oxic aquifers.

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Chlorinated ethenes (CEs) are legacy contaminants whose chemical footprint is expected to persist in aquifers around the world for many decades to come. These organohalides have been reported in river systems with concerning prevalence and are thought to be significant chemical stressors in urban water ecosystems. The aquifer-river interface (known as the hyporheic zone) is a critical pathway for CE discharge to surface water bodies in groundwater baseflow.

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Ferrihydrite is the most common iron oxyhydroxide found in soil and is a key sequester of contaminants in the environment. Ferrihydrite formation is also a common component of many treatment processes for cleanup of industrial effluents. Here we characterize ferrihydrite formation during the titration of an acidic ferric nitrate solution with NaOH.

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Integrated approaches for the identification of pollutant linkages between aquifers and streams are of crucial importance for evaluating the environmental risks posed by industrial contaminants like trichloroethene (TCE). This study presents a systematic, multi-scale approach to characterising groundwater TCE discharge to a 'gaining' UK lowland stream receiving baseflow from a major Permo-Triassic sandstone aquifer. Beginning with a limited number of initial monitoring points, we aim to provide a 'first pass' mechanistic understanding of the plume's fate at the aquifer/stream interface using a novel combination of streambed diffusion samplers, riparian monitoring wells and drive-point mini-piezometers in a spatially nested sampling configuration.

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A recent study estimates that 15.2 percent of American adults use nonprescription dietary supplements for weight loss. Sale of ephedrine- and ephedrine-alkaloid-containing products was prohibited by the Food and Drug Administration in February 2004 after research demonstrated an increased risk of arrhythmia, mortality and hypertension following use of products containing these sympathomimetics.

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In this study the expression of c-erbB-3 protein was investigated in a range of human ovarian tumours using a monoclonal antibody (RTJ1) raised to a synthetic peptide from the cytoplasmic domain of the human c-erbB-3 protein. A total of 73 samples from 71 patients were graded as negative, weak, moderate or strong according to the intensity of immunohistochemical staining observed, and this was related to tumour characteristics and other clinical parameters. In terms of positivity vs negativity, of the 73 samples examined, 62 (85%) showed positive immunohistochemical staining for c-erbB-3.

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The study investigated the workload offered by sport-related trauma to a busy casualty clinic and was carried out in two parts. The first part concerned compiling information about sport-related injuries presenting in 1 year to the outpatient eye clinic at Bradford Royal Infirmary. The second part attempted to investigate the awareness and the use of eye-protectors for squash by the student community of Bradford University, using a questionnaire.

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Visual function loss has been documented in diabetes mellitus in relation to flicker and contrast. However, no direct correlation between the degree of loss in sensitivity and the level of retinopathy has been established. It has been suggested that such non-invasive psychophysical procedures actually reflect metabolic disturbances within the diabetic retina.

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Conventional techniques for assessing the visual function of cataract patients include visual acuity (VA), contrast sensitivity (CS) and glare disability (GD). The extent to which these measurements provide accurate information about a patient's perceived visual disability is not known. In this study, binocular and monocular VA and CS and monocular GD measurements were made using commercially available techniques on 33 cataract patients.

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In a prospective study, designed to test the effect of intraocular lenses containing an ultraviolet absorbing chromophore on the incidence of post-operative cystoid macular oedema, 55 patients undergoing extracapsular cataract extraction were randomly allocated to receive intraocular lenses with or without an ultra-violet absorbing chromophore. Post-operative fluorescein angiography showed no difference in the incidence of macular oedema in those patients receiving an intraocular lens with an ultraviolet absorbing chromophore compared with patients receiving a standard posterior chamber intraocular lens.

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A retrospective review of the BD8 forms submitted for the period 1980-85 in the Bradford Metropolitan District was conducted to ascertain the incidence and causes of blindness and partial sight. A total of 1485 cases were registered in this period of which 755 (50%) were included in the Blind register and 730 (49.2%) in the Partially Sighted register.

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