Publications by authors named "Weam Mohammed"
Post-COVID-19 Syndrome Clinical Manifestations: A Systematic Review.
Muhammad Abdel-Gawad Mariam S Zaghloul Sherief Abd-Elsalam Mai Hashem Sameh A Lashen Ahmed Q Mohammed Weam Mohammed
Antiinflamm Antiallergy Agents Med Chem
October 2022
Article Synopsis
- COVID-19 can lead to ongoing health issues post-recovery, affecting multiple body systems including the lungs and mental health, with symptoms like fatigue and anxiety lingering in many patients.
- * A systematic review of literature involving 12 studies found that 35% to 90.5% of COVID-19 survivors report various post-recovery symptoms.
- * The most common ongoing symptoms identified include fatigue, dyspnea (shortness of breath), neuropsychological issues, and pain.
Article Synopsis
- - Celecoxib is a selective COX2 inhibitor known for having fewer side effects like high blood pressure and clotting issues, likely due to its ability to inhibit PDE5 and enhance blood vessel relaxation.
- - Researchers developed new compounds based on celecoxib’s structure, focusing on creating a 1,3,5-trisubstituted pyrazoline scaffold that increases PDE5 inhibition while eliminating COX2 activity.
- - The modifications made led to new PDE5 inhibitors that are about 20 times more potent than celecoxib without COX2 effects, suggesting potential for fewer side effects in treatments for erectile dysfunction and pulmonary hypertension.