Enzyme-free detection of creatinine as a kidney dysfunction biomarker using TiO flow-through membranes.

TiO nanotube flow-through membranes (TNTsM) were fabricated anodization of Ti foil and explored as a biosensing platform for creatinine detection. The electrodes were prepared in different configurations including TNT membrane with top surface up (TNTsMTU/TNPs/FTO), TNT membrane with bottom surface up (TNTsMBU/TNPs/FTO), TNT membrane with top surface up containing nanograss (TNTsMNG/TNPs/FTO), and TNTs/NPs/FTO and TiO nanoparticles (TNPs) film on fluorine doped tin oxide (TNPs/FTO). Electrochemical studies depict the higher electrochemical activity (sensitivity ∼19.

Assessment of natural radioactivity levels in rice samples and their implications for radiological protection.

This study investigates the levels of natural and artificial radioactivity in rice samples collected from various local markets in Islamabad, Pakistan. The Ra, Th, and K activity concentrations were measured through gamma-ray spectrometry with a NaI(Tl) detector. The average activity concentrations were 1.

Pharmacognostic Evaluation, Chemical Characterization, and Antibacterial Activity of (Wight) A.J. Scott.

(Wight) A.J. Scott is an Indian origin plant with documented medicinal and nutritional value, but has not been fully characterized yet.

Artificial neural network-assisted prediction of radiobiological indices in head and neck cancer.

Background And Purpose: We proposed an artificial neural network model to predict radiobiological parameters for the head and neck squamous cell carcinoma patients treated with radiation therapy. The model uses the tumor specification, demographics, and radiation dose distribution to predict the tumor control probability and the normal tissue complications probability. These indices are crucial for the assessment and clinical management of cancer patients during treatment planning.

Investigating the Antibacterial and Anti-inflammatory Potential of Polyol-Synthesized Silver Nanoparticles.

Silver nanoparticles (Ag-NPs) were synthesized by using the polyol method. The structural and morphological characteristics of Ag-NPs were studied by using X-ray diffraction (XRD) and field-emission scanning electron microscopy (FE-SEM). The XRD analysis revealed the formation of single-phase polycrystalline Ag-NPs with an average crystallite size and lattice constant of ∼23 nm and 4.

A text analytics approach for mining public discussions in online cancer forum: Analysis of multi-intent lung cancer treatment dataset.

Background: Online cancer forums (OCF) are increasingly popular platforms for patients and caregivers to discuss, seek information on, and share opinions about diseases and treatments. This interaction generates a substantial amount of unstructured text data, necessitating deeper exploration. Using time series data, our study exploits topic modeling in the novel domain of online cancer forums (OCFs) to identify meaningful topics and changing dynamics of online discussion across different lung cancer treatment intent groups.

Fahr's Syndrome: A Rare Case Presentation.

Idiopathic basal ganglia calcification (IBGC), also known as Fahr's disease, is a rare neurological disorder characterized by metabolic, biochemical, neuroradiological, and neuropsychiatric alterations resulting from symmetrical and bilateral intracranial calcifications. In most cases, an autosomal dominant pattern of inheritance and genetic heterogeneity is observed. Neuropsychiatric symptoms with movement disorders account for 55% of the manifestations of this disease.

COVID-19 Pandemic Lessons for Creating Effective Mental Health Safety Nets in Lower Middle-Income Countries.

The coronavirus disease 2019 (COVID-19) pandemic has posed unprecedented challenges to mental health globally, particularly in low- and middle-income countries (LMICs) such as Pakistan. This narrative review aims to synthesize the literature on the impact of the pandemic on mental health in LMICs, the challenges and opportunities for mental health system reform, and the role of safety nets in promoting mental health. A comprehensive search was conducted in several electronic databases, resulting in 35 articles being included for review.

Viability of the virtual cone technique using a fixed small multi-leaf collimator field for stereotactic radiosurgery of trigeminal neuralgia.

Dosimetric uncertainties in very small (≤1.5 × 1.5 cm ) photon fields are remarkably higher, which undermines the validity of the virtual cone (VC) technique with a diminutive and variable MLC fields.

Psychiatric Illnesses, Somatic Complaints, and Treatments in a Tertiary Care Hospital in Khyber Pakhtunkhwa, Pakistan: A Cross-Sectional Study.

Background: Psychiatric disorders differ in frequency and symptoms based on the cultural and ethnic background of patients. This can make diagnosing and treating patients challenging globally. In Pakistan, most psychiatric patients report multiple somatic complaints.

Liver cancer risk quantification through an artificial neural network based on personal health data.

Background: Liver cancer is one of the most common types of cancer and the third leading cause of cancer-related deaths globally. The most common type of primary liver cancer is called hepatocellular carcinoma (HCC) which accounts for 75-85% of cases. HCC is a malignant disease with aggressive progression and limited therapeutic options.

Statistical biopsy: An emerging screening approach for early detection of cancers.

Despite large investment cancer continues to be a major source of mortality and morbidity throughout the world. Traditional methods of detection and diagnosis such as biopsy and imaging, tend to be expensive and have risks of complications. As data becomes more abundant and machine learning continues advancing, it is natural to ask how they can help solve some of these problems.

A novel Monte Carlo (MC) dose model for small MLC fields of the cyberknife M6 radiosurgery system using the EGSnrc.

The multi-leaf collimator (MLC)-equipped CyberKnife M6 radiosurgery system (CKM6) (Accuray Inc., Sunnyvale, CA) has been increasingly employed for stereotactic radiosurgery (SRS) to treat relatively small lesions. However, achieving an accurate dose distribution in such cases is usually challenging due to the combination of numerous small fields ≤ (30 × 30) mm .

Multifaced Assessment of Antioxidant Power, Phytochemical Metabolomics, In-Vitro Biological Potential and In-Silico Studies of L.: An Important Medicinal Plant.

This work was undertaken to explore the phytochemical composition, antioxidant, and enzyme-inhibiting properties of L. extracts/fractions of varying polarity (methanol extract and its fractions including -hexane, chloroform, -butanol, and aqueous fractions). A preliminary phytochemical study of all extracts/fractions, HPLC-PDA polyphenolic quantification, and GC-MS analysis of the -hexane fraction were used to identify the phytochemical makeup.

Banti's Syndrome in an Adult Male: A Case Report.

Banti's syndrome is a chronic congestive enlargement of the spleen leading to the destruction of blood cells resulting in pancytopenia. It is also associated with cirrhosis and ascites along with symptoms of pancytopenia such as infection, bruising, weakness, and fatigue. Multiple factors such as hepatitis B infection, coagulation abnormalities and exposure to arsenic, etc.

Juvenile Alexander Disease: A Rare Leukodystrophy.

Alexander disease is an uncommon autosomal dominant leukodystrophy that influences the white matter of the central nervous system (CNS), predominantly affecting the frontal lobe bilaterally. The most obvious pathogenic hallmark is the extensive deposition of cytoplasmic inclusions known as "Rosenthal fibers" in perivascular, subpial, and subependymal astrocytes throughout the CNS. The hereditary cause is mutations in the glial fibrillary acidic protein (GFAP) gene.

A Rare Case of Hereditary Hemorrhagic Telangiectasia: A Case Report.

Hereditary hemorrhagic telangiectasia (HHT), also known as Osler-Weber-Rendu syndrome, is a very rare autosomal dominant genetic disorder that leads to abnormal blood vessel formation in the skin, mucus membranes (called telangiectasia), and organs such as the lung, liver, and brain. It occurs due to a mutation in one of the , , and  genes, which code for the formation of blood vessels. The most common symptom is recurring nosebleed (epistaxis; due to rupture of nasal mucosal telangiectasia), which begins in childhood and affects about 90-95% of people with HHT.

Review on 2D Molybdenum Diselenide (MoSe) and Its Hybrids for Green Hydrogen (H) Generation Applications.

Hydrogen (H) is a green and economical substitute to traditional fossil fuels due to zero carbon emissions. Water splitting technology is developing at a rapid speed to sustainably generate H through electro- and photolysis of water without the harmful emissions associated with steam methane reforming. Development of efficient catalysts for the hydrogen evolution reaction (HER) is pertinent for economical green H generation.

Frequency of Acute Viral Hepatitis A, B, C, and E in Pregnant Women Presenting to Hayatabad Medical Complex, Peshawar, Pakistan.

Objective To determine the frequency of hepatitis A, B, C, and E viruses (HAV, HBV, HCV, HEV) in pregnant women with acute hepatitis presenting to the medical units of HMC, Peshawar. Methods This is a descriptive cross-sectional study in which 442 pregnant women, either multi or primigravida, with yellow discolouration of the sclerae of the eyes and elevated alanine aminotransferase (ALT) > 100 U/L on laboratory tests were chosen by convenience (non-probability) sampling to assess the frequency of HAV, HBV, HCV, HEV. Results The majority, i.

A Rare Case of Insulinoma in a Thin, Lean Adult Male: A Case Report.

Insulinoma is an insulin-secreting tumor that causes hypoglycemia due to inappropriately high insulin secretion. The Whipple's triad, which comprises indications of hypoglycemia (tremor, sweating, irritability, uneasiness, and weakness), plasma glucose concentration <55 mg/dL (3.0 mmol/L), and resolution of symptoms after administration of glucose, is utilized for the determination of insulinoma.

Design and Characterization of Agarose/HPMC Buccal Films Bearing Ondansetron HCl In Vitro and In Vivo: Enhancement Using Iontophoretic and Chemical Approaches.

The study was aimed at designing and characterizing the ondansetron hydrochloride (OND) bearing agarose (AG), and hydroxypropyl methyl cellulose (HPMC) mucoadhesive buccal films employing glycerol as a plasticizer. The buccal delivery of ondansetron hydrochloride was remarkably boosted by employing physical (iontophoresis) and chemical enhancement approaches (chemical penetration enhancers). To explore the influence of different formulation components, i.

Association and Effects of Trauma, Displacement, and Illicit Drug Use on Psychiatric Illnesses in Khyber Pakhtunkhwa, Pakistan.

Methodology Data were accumulated from all patients seen in outpatient clinics from October to December 2020. No inpatients or community samples were included in the research. Verbal consent and approval from the local ethical committee were obtained beforehand.

Examining the Determinants of Patient Perception of Physician Review Helpfulness across Different Disease Severities: A Machine Learning Approach.

(1) . Patients are increasingly using physician online reviews (PORs) to learn about the quality of care. Patients benefit from the use of PORs and physicians need to be aware of how this evaluation affects their treatment decisions.

Cardiovascular Diseases in the Patients With Psoriatic Arthritis.

There are limited data regarding the burden and trend of cardiovascular diseases (CVD) in psoriatic arthritis (PsA). We analyzed the National Inpatient Sample database from January 2005 to December 2018 to examine the hospitalization trends amongst adults with PsA primarily for heart failure (HF), acute myocardial infarction (AMI), and stroke. The primary outcomes of interest included in-hospital mortality, length of stay (LOS), and inflation-adjusted cost.