Vacuum inversion and securing of distal colonic pseudodiverticula with novel spiked O-rings.

Background: Diverticular disease is increasingly prevalent in Western societies and is associated with significant morbidity.

Objective: Two-stage endoscopic device development for inversion and secured ligation of colonic diverticula; first, human cadaver studies were performed to measure forces required for diverticular inversion; second, a novel set of devices (elastic spiked O-ring with delivery system) was tested in animals.

Design: Prospective, observational study of human cadavers and prospective, interventional study of a porcine model.

A novel endoscopic device for repeated right-side colonic access during colonoscopy (with video).

Background: Megachannel is a newly developed colonic access system allowing rapid and multiple passes of the colonoscope to the right side of the colon.

Objective: The aim of this study was to evaluate the safety and clinical feasibility of placing a 100 cm Megachannel prototype in the right side of the colon.

Setting: Six centers, international, both surgeons and gastroenterologists performing endoscopy.

Design and instrumentation of new devices for performing appendectomy at colonoscopy (with video).

Background: There is increasing interest in natural orifice surgery (NOS). Because the lumen of the appendix is connected to the cecum, a minimally invasive method for removing the appendix by colonoscopy may be feasible.

Objectives: Our purpose was to design, develop, and test new devices for inverting and removing the appendix by colonoscopy.