Enhancing aggregate reduction using anion exchange hybrid filter in an immunocytokine diabody fusion protein purification process.

Significant aggregation challenges were encountered during the manufacturing processing of an immunocytokine diabody fusion protein. To mitigate this issue and reduce aggregates in the purification process, a variety of depth filters were evaluated for harvest clarification and post-Protein A intermediate filtration. Emphaze™ AEX Hybrid Purifier, a fully synthetic quaternary amine functionalized anion exchange (AEX) nonwoven filter, was found to be particularly effective in removing aggregates during both harvest clarification and post-Protein A intermediate filtration steps.

A Rare Case of Infliximab-Induced Small Vessel Vasculitis With Renal Involvement.

There are few cases in the literature demonstrating vasculitis induced by tumor necrosis factor-α. There exist even fewer cases of systemic inflammation involving the skin, nerves, and kidneys. Here, we present a novel case of a 27-year-old man with Crohn disease refractory to multiple medications, most recently treated with infliximab.

Evaluating the long-term portrayal of antibiotic resistance in major U.S. newspapers.

Background: Popular media play a critical role in informing the public about antibiotic resistance, which has remained a health concern for over seven decades. Media attention increases the notoriety of antibiotic resistance and shapes the public's perception of its severity, causes, and solutions. Therefore, it is critical the media accurately portray scientific knowledge that may shape personal and policy responses to antibiotic resistance.

Extramural venous invasion: a novel magnetic resonance imaging biomarker for adverse pathology in bladder cancer.

Extramural venous invasion (EMVI) recognized on magnetic resonance imaging (MRI) is an unequivocal biomarker for detecting adverse outcomes in rectal cancer: however it has not yet been explored in the area of bladder cancer. In this study, we assessed the feasibility of identifying EMVI findings on MRI in patients with bladder cancer and its avail in identifying adverse pathology. In this single-institution retrospective study, the MRI findings inclusive of EMVI was described in patients with bladder cancer that had available imaging between January 2018 and June 2020.

Advancing Digital Health Innovation in Oncology: Priorities for High-Value Digital Transformation in Cancer Care.

Although health care delivery is becoming increasingly digitized, driven by the pursuit of improved access, equity, efficiency, and effectiveness, progress does not appear to be equally distributed across therapeutic areas. Oncology is renowned for leading innovation in research and in care; digital pathology, digital radiology, real-world data, next-generation sequencing, patient-reported outcomes, and precision approaches driven by complex data and biomarkers are hallmarks of the field. However, remote patient monitoring, decentralized approaches to care and research, "hospital at home," and machine learning techniques have yet to be broadly deployed to improve cancer care.

Howiesons Poort backed artifacts provide evidence for social connectivity across southern Africa during the Final Pleistocene.

Examining why human populations used specific technologies in the Final Pleistocene is critical to understanding our evolutionary path. A key Final Pleistocene techno-tradition is the Howiesons Poort, which is marked by an increase in behavioral complexity and technological innovation. Central to this techno-tradition is the production of backed artifacts-small, sharp blades likely used as insets in composite tools.

Graphene nanoribbons initiated from molecularly derived seeds.

Semiconducting graphene nanoribbons are promising materials for nanoelectronics but are held back by synthesis challenges. Here we report that molecular-scale carbon seeds can be exploited to initiate the chemical vapor deposition (CVD) synthesis of graphene to generate one-dimensional graphene nanoribbons narrower than 5 nm when coupled with growth phenomena that selectively extend seeds along a single direction. This concept is demonstrated by subliming graphene-like polycyclic aromatic hydrocarbon molecules onto a Ge(001) catalyst surface and then anisotropically evolving size-controlled nanoribbons from the seeds along [Formula: see text] of Ge(001) via CH CVD.

Pericardial Effusion during Proton Therapy in a Patient with Chemorefractory Hodgkin Lymphoma.

We present a case of recurrent pericardial effusion presenting during proton therapy in a 24-year-old female receiving mediastinal treatment for classical Hodgkin lymphoma. Pericardial effusion is typically considered an event accompanying lymphoma diagnosis or as a subacute or late effect of radiotherapy. Rarely has it been described as occurring during radiation treatment with photon-based radiotherapy, let alone proton therapy.

Natural selection and the 'antiquity of man': Intellectual impacts in the Australian colonies.

Two months before the publication of Charles Darwin's On the Origin of Species (1859), Scottish geologist Charles Lyell announced a consensus on 'the antiquity of man.' Although stemming from separate intellectual traditions, human antiquity and natural selection had such a powerful influence on nineteenth century science that the former is often thought to be an inevitable conceptual and chronological consequence of the latter. Various scholars have argued it was in fact the acceptance of human antiquity that provided a foundation for the intelligibility and eventual acceptance of evolution by natural selection.

A review of the state-of-the-art in automatic post-editing.

This article presents a review of the evolution of automatic post-editing, a term that describes methods to improve the output of machine translation systems, based on knowledge extracted from datasets that include post-edited content. The article describes the specificity of automatic post-editing in comparison with other tasks in machine translation, and it discusses how it may function as a complement to them. Particular detail is given in the article to the five-year period that covers the shared tasks presented in WMT conferences (2015-2019).

Potential positive effects of bariatric surgery on healthcare resource utilisation.

Background: To determine whether a bariatric surgical procedure is associated with a reduction in healthcare utilisation among patients with obesity and high pre-procedural healthcare needs.

Methods: Design: Retrospective cohort study.

Setting: Tertiary Victorian public hospital.

Diffusion Weighted Imaging in Unilateral Adrenal Infarction: A Case of Colicky Right Upper Quadrant Pain in a Pregnant Female.

Diffusion weighted imaging (DWI) is a magnetic resonance imaging (MRI) non-contrast sequence that can indicate tissue ischemia or infarction. Adrenal infarct may present similarly to biliary or gallbladder pathologies, and the differential diagnosis during emergency work-up can be narrowed utilizing DWI sequences. In this paper, we describe the usefulness of DWI for urgent diagnosis in a case of non-hemorrhagic adrenal infarct of a pregnant female presenting with right upper quadrant pain.

It's Not Always Gynecomastia: A Case of Diffuse Large B-Cell Lymphoma Presenting as Breast Mass in a Male Patient.

We report a case of diffuse large B-cell breast lymphoma that presented as a palpable breast lump in a male patient evaluated with digital mammography and targeted breast ultrasound (US) but ultimately confirmed by US-guided core needle biopsy. We will discuss the appropriate workup algorithm for a palpable breast lump in a male patient as outlined by the American College of Radiology (ACR) Appropriateness Criteria. While gynecomastia is the most common reason for a new palpable breast lump in a male patient, male breast cancer (including lymphoma and metastasis) can have a similar appearance on imaging.

A Case of Carotid Body Tumor with Perineural Tumor Spread along the Superior Laryngeal Nerve.

We report a case of a patient with a carotid body tumor with perineural tumor spread along the right superior laryngeal nerve. Perineural spread is most commonly associated with squamous cell, adenoid cystic, and mucoepidermoid carcinoma. To the best of our knowledge, this has not been reported previously with carotid body tumor.

Improving eye screening practice among pediatric rheumatology patients receiving hydroxychloroquine.

Objective: Hydroxychloroquine (HCQ) is commonly used in the treatment of various autoimmune diseases related to its many benefits and favorable safety profile. Although HCQ retinopathy was considered to be uncommon, a prevalence of 7.5% was described in a recent study making early detection critical.

Radiation-Induced Rib Fractures on Magnetic Resonance Imaging Following Proton Therapy for Breast Cancer With Pencil Beam Scanning.

Radiation-induced rib fractures (RIRF) are long-term complications associated with irradiation of the chest/chest wall. RIRFs are commonly seen in lung- or breast-cancer patients treated with stereotactic body radiotherapy (SBRT) or conventional external beam radiation therapy (EBRT), respectively. We report a case of a 31-year-old female presenting with pathological fractures of the third, fourth, and fifth ribs discovered on magnetic resonance imaging (MRI) as a complication from pencil beam scanning (PBS) proton therapy (PT), of the whole left breast and regional lymph nodes.

A new Monte Carlo simulation tool for designing an archaeological landscape sampling strategy.

This article describes in detail how the Dig It, Design It (DIDI) simulation tool operates to design a subsurface landscape sampling strategy and predict its likely effectiveness. The purpose of the DIDI model is to help archaeologists develop statistically sound subsurface sampling programs that maximise the number of sites found while minimising the number of sampling units used. It has been unusual for archaeological test-pitting programs to be theoretically tested or statistically justified by simulation prior to implementation.

MRI of myositis and other urgent muscle-related disorders.

Myositis has many etiologies, and it can be encountered in the acute or chronic setting. Our goal is to increase the radiologist's knowledge of myositis and other urgent muscle disorders encountered in the emergent or urgent setting. We review the clinical presentation, the MRI appearance, and the complications that can be associated with these entities.

A roadmap to neural automatic post-editing: an empirical approach.

In a translation workflow, machine translation (MT) is almost always followed by a human post-editing step, where the raw MT output is corrected to meet required quality standards. To reduce the number of errors human translators need to correct, automatic post-editing (APE) methods have been developed and deployed in such workflows. With the advances in deep learning, neural APE (NPE) systems have outranked more traditional, statistical, ones.

Multimodality Imaging Approach in Evaluation of Post-Traumatic Bronchobiliary Fistulas.

Post-traumatic bronchobiliary fistulas (BBF) are extremely rare with high morbidity and mortality rates. Accurate and timely diagnosis of these entities is critical for appropriate treatment, which usually requires a multidisciplinary approach. We describe two post-traumatic cases using a multimodality approach including computed tomography (CT), magnetic resonance imaging (MRI)/Magnetic Resonance Cholangiopancreatography (MRCP), and hepatobiliary scintigraphy with specific emphasis on the imaging features for each modality.

Boundary-directed epitaxy of block copolymers.

Directed self-assembly of block copolymers (BCPs) enables nanofabrication at sub-10 nm dimensions, beyond the resolution of conventional lithography. However, directing the position, orientation, and long-range lateral order of BCP domains to produce technologically-useful patterns is a challenge. Here, we present a promising approach to direct assembly using spatial boundaries between planar, low-resolution regions on a surface with different composition.

Anisotropic Synthesis of Armchair Graphene Nanoribbon Arrays from Sub-5 nm Seeds at Variable Pitches on Germanium.

At widths below 10 nm, armchair graphene nanoribbons become semiconductors. One promising route to synthesize nanoribbons is chemical vapor deposition (CVD) of hydrocarbons on Ge(001), and synthesis from seeds reduces nanoribbon polydispersity. In this contribution, we advance the seed-initiated synthesis of nanoribbons and explore the impact of seed size and nanoribbon spacing on growth kinetics.